3 Year simvastatin treatment and lens nuclear back scattering

British Journal of Ophthalmology

Volumn 84, Issue 5, 2000, Pages 512-516

  Qian, Wen ^a   Söderberg, Per G ^a   Chen, Enping ^a   Magnius, Karin ^a   Philipson, Bo ^a  

^a ST ERIK S EYE HOSPITAL   (Sweden)

Author keywords

[No Author keywords available]

Indexed keywords

SIMVASTATIN;

ADULT; AGED; AGING; ARTICLE; CLINICAL TRIAL; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; FEMALE; FOLLOW UP; HUMAN; HYPERCHOLESTEROLEMIA; LENS DISEASE; LENS NUCLEUS; MAJOR CLINICAL STUDY; MALE; PHOTOGRAPHY; PRIORITY JOURNAL; RANDOMIZED CONTROLLED TRIAL; SEX DIFFERENCE; SLIT LAMP;

ADULT; AGE FACTORS; AGED; ANTICHOLESTEREMIC AGENTS; FEMALE; FOLLOW-UP STUDIES; HUMANS; HYPERCHOLESTEROLEMIA; LENS NUCLEUS, CRYSTALLINE; MALE; MIDDLE AGED; REGRESSION ANALYSIS; SCATTERING, RADIATION; SEX FACTORS; SIMVASTATIN;

EID: 1642586740     PISSN: 00071161     EISSN: None     Source Type: Journal    
DOI: 10.1136/bjo.84.5.512     Document Type: Article

References (38)

1. The Expert Panel. Report of the national cholesterol education program expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Arch Intern Med 1988;148:36-69. [Review] Cardiology 1990;77(Suppl 4):58-65.
2. The Expert Panel. Report of the national cholesterol education program expert panel on detection, evaluation, and treatment of high blood cholesterol in adults. Arch Intern Med 1988;148:36-69. [Review] Cardiology 1990;77(Suppl 4):58-65.
3. Bilheimer DW. Long-term clinical tolerance of lovastatin and simvastatin. [Review] Cardiology 1990;77(Suppl 4):58-65.
4. Jones PH. Lovastatin and simvastatin prevention studies. [Review] Am J Cardiol 1990;66:39B-43B.
5. The Scandinavian Simvastatin Survival Study Group. Randomised trial of cholesterol lowering in 4444 patients with coronary heart disease: the Scandinavian Simvastatin Survival Study (4S). Lancet 1994;344:1383-1389 (No 8934).
6. Gerson RJ, MacDonald JS, Alberts AW, et al. On the etiology of subcapsular lenticular opacities produced in dogs receiving HMG-CoA reductase inhibitors. Exp Eye Res 1990;50:65-78.
7. Harris ML, Bron AJ, Brown NAP, et al. Absence of effect of simvastatin on the progression of lens opacities in a randomsed placebo controlled study. Br J Ophthalmol 1995;79:996-1002.
8. Boccuzzi SJ, Bocanegra TS, Walker JF, et al. Long-term safety and efficacy profile of simvastatin. Am J Cardiol 1991;68:1127-31.
9. Leclercq V, Harvengt C. Simvastatin (MK 733) in heterozygous familial hypercholesterolemia: a two-year trial. Int J Clin Pharmacol 1989;27:76-81.
10. Lundh BL, Nilsson SE. Lens changes in matched normals and hyperlipidemic patients treated with simvastatin for 2 years. Acta Ophthalmol (Copenh) 1990;68:658-60.
11. Schmidt J, Schmitt C, Hockwin O. No lens changes caused by simvastatin results from a prospective drug safety study. Lens Eye Toxic Res 1990;7:643-50.
12. Schmidt J, Schmitt C, Hockwin O, et al. Ocular drug safety and HMG-CoA-reductase inhibitors. Ophthalmic Res 1994;26:352-60.
13. Behrens-Baumann W, Thiery J, Wieland E, et al. 3-Hydroxy-3-methylglutaryl coenzyme A reductase inhibitor simvastatin and the human lens. Clinical results of a 3-year follow-up. Arzneim-Forsch/Drug Res 1992;42:1023-4.
14. Molgaard J, Lundh BL, von Schenck H, et al. Long-term efficacy and safety of simvastatin alone and in combination therapy in treatment of hypercholesterolemia. Atherosclerosis 1991;91(Suppl):S21-8.
15. Pedersen TR, Berg K, Cook TJ, et al. Safety and tolerability of cholesterol lowering with simvastatin over 5 years in the Scandinavian Simvastatin Survival Study (4S). Arch Intern Med 1996;156:2085-92.
16. Dragomirescu V, Hockwin O, Koch H, et al. Development of a new equipment for rotating slit image photography according to Scheimpflug's principle. Interdiscipl Topics Geront 1978;13:1-13.
17. World Health Organisation. Guidelines for the clinical investigation of anticataract drugs in senile cataract. Copenhagen: WHO Regional Office for Europe, 1985.
18. Qian W, Söderberg PG, Chen E, et al. A common lens nuclear area in Scheimpflug photographs. Eye 1993;7:799-804.
19. Qian W, Söderberg PG, Chen E, et al. Evaluation of gray scale steps on Scheimpflug photographs. Acta Ophthalmol 1993;71:79-84.
20. Hockwin O, Dragomirescu V, Laser H. Measurements of lens transparency or its disturbances by densitometric image analysis of Scheimpflug photography. Graefes Arch Clin Exp Ophthalmol 1982;219:255-62.
21. Lindström B, Philipson B. Microdensitometer system for microradiography. Histochemie 1969;17:187-93.
22. Qian W, Söderberg PG, Lindström B, et al. Spatial distribution of back scattering in the nuclear area of the non-cataractous human lens. Eye 1994;8:524-9.
23. Bennett C, Franklin N. Analysis involving both types of classification. In: Statistical analysis in chemistry and the chemical industry. New York: John Wiley, 1963; chap 7.63.
24. Wonnacott TH, Wonnacott RJ. Multiple regression. In: Introductory statistics. New York: John Wiley, 1990;v 5,chap 13.
25. Sasaki K, Shibata T. Age-related changes of lens transparency: image analysis by photographic sensitometry. In: Henkind P, ed. XXIV International Congress of Ophthalmology. Philadelphia: JB Lippincott, 1983.
26. Bosem ME, Sample PA, Martinez GA, et al. Age-related changes in the human lens: a comparison of Scheimpflug photography and lens density index. J Cataract Refract Surg 1994;20:70-3.
27. Kashima K, Trus BL, Unser M, et al. Aging studies on normal lens using the Scheimpflug slit-lamp camera. Invest Ophthalmol Vis Sci 1993;34:263-9.
28. Chylack LT Jr, Rosner B, Cheng HM, et al. Sources of variance in the objective documentation of human cataratous change with Topcon SL-45 and Neitz-CTR retroillumination photography and computerized image analysis. Curr Eye Res 1987;6:1381-9.
29. Chen T, Mayer H, Bates S, et al. Inter-and intra-operator correlation study of SL-45 lens photography. Lens Res 1988;5:43-54.
30. Wolfe JK, Friend J, Singer DM, et al. Assessment of the ability of methods of measuring cataract to detect clinically significant change. Ophthalmic Res 1994;26(suppl 1):55-60.
31. Chen SY, Chylack LT Jr, White O. Topcon SL-45 photography, a suitable technique for documenting nuclear but not cortical cataractous change in vivo. Invest Ophthalmol Vis Sci 1985;(suppl)26:119.
32. Sparrow JM, Brown NAP, Ayliffe W, et al. The Oxford clinical cataract classification and grading system. Int Ophthalmol 1986;9:207-25.
33. Brown NA, Bron AJ, Ayliffe W, et al. The objective assessment of cataract. Eye 1987;1:234-46.
34. Datiles MB, Edwards PA, Trus BL, et al. In vivo studies on cataracts using the Scheimpflug slit lamp camera. Invest Ophthalmol Vis Sci 1987;28:707-10.
35. Edwards PA, Datiles MB, Green SD, et al. Reproducibility study on the Scheimpflug cataract video camera. Curr Eye Res 1988;7:955-60.
36. Edwards PA, Datiles MB, Unser M, et al. Computerized cataract detection and classification. Curr Eye Res 1990;9: 517-24.
37. West S, Rosenthal F, Newland HS, et al. Use of photographic techniques to grade nuclear cataract. Invest Ophthalmol Vis Sci 1988;29:73-7.
38. Qian W. Angular change of back scattering of light from the human lens with nuclearcataract. Eye (in press).