Transfer of Risperidone and 9-Hydroxyrisperidone into Human Milk

Annals of Pharmacotherapy

Volumn 38, Issue 2, 2004, Pages 273-276

  Ilett, Kenneth F ^a   Hackett, L Peter ^b   Kristensen, Judith H ^c   Vaddadi, Krishna S ^d   Gardiner, Sharon J ^e   Begg, Evan J ^f  

^a UNIVERSITY OF WESTERN AUSTRALIA   (Australia)

^b Western Australian Centre for Pathology and Medical Research   (Australia)

^c K Edward Mem/Prncs Margaret Hosp   (Australia)

^d MONASH UNIVERSITY   (Australia)

^e CHRISTCHURCH HOSPITAL   (New Zealand)

^f UNIVERSITY OF OTAGO   (New Zealand)

Author keywords

9 hydroxyrisperidone; Breast milk; Risperidone

Indexed keywords

PALIPERIDONE; RISPERIDONE;

ADULT; AREA UNDER THE CURVE; ARTICLE; BREAST FEEDING; BREAST MILK; CALCULATION; CASE REPORT; DEPRESSIVE PSYCHOSIS; FEMALE; GALACTORRHEA; HUMAN; PRIORITY JOURNAL; RISK ASSESSMENT; SCHIZOPHRENIA;

ADULT; AREA UNDER CURVE; BREAST FEEDING; DEPRESSION, POSTPARTUM; FEMALE; GALACTORRHEA; HUMANS; INFANT; ISOXAZOLES; MALE; MILK, HUMAN; PYRIMIDINES; RISPERIDONE;

EID: 1642580691     PISSN: 10600280     EISSN: None     Source Type: Journal    
DOI: 10.1345/aph.1D326     Document Type: Article

References (7)

1. Ernst CL, Goldberg JF. The reproductive safety profile of mood stabilizers, atypical antipsychotics, and broad-spectrum psychotropics. J Clin Psychiatry 2002;63(suppl 4):42-55.
2. MIMS abbreviated prescribing information. Risperdal (risperidone). EMIMS Version 4.00.0062. St Leonards, Australia: MediMedia Australia Pty, 2003.
3. Mihara K, Kondo T, Yasui-Furukori N, Suzuki A, Ishida M, Ono S, et al. Effects of various CYP2D6 genotypes on the steady-state plasma concentrations of risperidone and its active metabolite, 9-hydroxyrisperidone, in Japanese patients with schizophrenia. Ther Drug Monit 2003;25:3287-93.
4. Hill RC, Mclvor RJ, Wojnar-Horton RE, Hackett LP, Ilett KF. Risperidone distribution and excretion into human milk: case report and estimated infant exposure during breast-feeding (letter). J Clin Psychopharmacol 2000;20:2285-6.
5. Bennett PN. Use of the monographs on drugs. In: Bennett PN, ed. Drugs and human lactation. 2nd ed. Amsterdam: Elsevier, 1996:67-74.
6. Begg EJ, Duffull SB, Hackett LP, Ilett KF. Studying drugs in human milk: time to unify the approach. J Hum Lact 2002;18:4319-28.
7. Ratnayake T, Libretto SE. No complications with risperidone treatment before and throughout pregnancy and during the nursing period. J Clin Psychiatry 2002;63:176-7.