Insulin Regulates Neuronal M2 Muscarinic Receptor Function in the Ileum of Diabetic Rats

Journal of Pharmacology and Experimental Therapeutics

Volumn 308, Issue 2, 2004, Pages 760-766

  Coulson, Fiona R ^a,b   Jacoby, David B ^a   Fryer, Allison D ^a  

^a The Johns Hopkins University   (United States)

^b GRIFFITH UNIVERSITY   (Australia)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYLCHOLINE; GLUCOSE; HUMAN INSULIN; INSULIN; METHOCTRAMINE; MUSCARINIC M2 RECEPTOR; MUSCARINIC M3 RECEPTOR; PILOCARPINE; STREPTOZOCIN;

ACETYLCHOLINE RELEASE; ANIMAL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BODY WEIGHT; CHOLINERGIC NERVE; CONCENTRATION RESPONSE; CONTROLLED STUDY; DIABETES MELLITUS; DIGESTIVE SYSTEM FUNCTION DISORDER; DOSE RESPONSE; DRUG ANTAGONISM; DRUG EFFECT; ELECTROSTIMULATION; EXPERIMENTAL DIABETES MELLITUS; GASTROINTESTINAL MOTILITY; GASTROINTESTINAL TRACT; GLUCOSE BLOOD LEVEL; ILEUM; IN VITRO STUDY; INTESTINE MUSCLE; MALE; METABOLISM; MUSCLE CONTRACTION; NERVE CELL; NERVE STIMULATION; NONHUMAN; PHYSIOLOGY; PRIORITY JOURNAL; RAT; RAT STRAIN; RECEPTOR DENSITY; RECEPTOR DOWN REGULATION; RECEPTOR UPREGULATION; SMOOTH MUSCLE; SMOOTH MUSCLE CONTRACTION; STREPTOZOCIN DIABETES;

ACETYLCHOLINE; ANIMALS; BLOOD GLUCOSE; BODY WEIGHT; DIABETES MELLITUS, EXPERIMENTAL; ELECTRIC STIMULATION; ILEUM; INSULIN; MALE; MUSCLE CONTRACTION; MUSCLE, SMOOTH; NEURONS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTOR, MUSCARINIC M2; RECEPTOR, MUSCARINIC M3;

EID: 1642579524     PISSN: 00223565     EISSN: None     Source Type: Journal    
DOI: 10.1124/jpet.103.057570     Document Type: Article

References (39)

1. Araujo DM, Lapchak PA, Collier B, Chabot JG, and Quirion R (1989) Insulin-like growth factor-1 (somatomedin-C) receptors in the rat brain: distribution and interaction with the hippocampal cholinergic system. Brain Res 484:130-138.
2. Aronson D (2001) Impaired modulation of circadian rhythms in patients with diabetes mellitus: a risk factor for cardiac thrombotic events? Chronobiol Int 18:109-121.
3. Baker DG, Don HF, and Brown JK (1992) Direct measurement of acetylcholine release in guinea pig trachea. Am J Physiol 263:L142-L147.
4. Baltensperger K, Karoor V, Paul H, Ruoho A, Czech MP, and Malbon CC (1996) The beta-adrenergic receptor is a substrate for the insulin receptor tyrosine kinase. J Biol Chem 271:1061-1064.
5. Belmonte KE, Fryer AD, and Costello RM (1998) Role of insulin in antigen-induced airway eosinophilia and neuronal M2 muscarinic receptor dysfunction. J Appl Physiol 85:1708-1718.
6. Belmonte KE, Jacoby DB, and Fryer AD (1997) Increased function of inhibitory neuronal M2 muscarinic receptors in diabetic rat lungs. Br J Pharmacol 121: 1287-1294.
7. Bittinger M, Barnert J, and Wienbeck M (1999) Autonomic dysfunction and the gastrointestinal tract. Clin Auton Res 9:75-81.
8. Blanco R, Saenz dT, I, Goldstein I, Krane RJ, Wotiz HH, and Cohen RA (1990) Dysfunctional penile cholinergic nerves in diabetic impotent men. J Urol 144:278-280.
9. Cheng JT, Hung CR, and Lin MI (1997) Stimulatory effect of porcine insulin on noradrenaline secretion in guinea-pig ileum myenteric nerve terminals. Br J Pharmacol 121:15-20.
10. Cost M and Majewski H (1991) Evidence for facilitatory and inhibitory muscarinic receptors on postganglionic sympathetic nerves in mouse isolated atria. Br J Pharmacol 102:855-860.
11. 2 muscarinic receptors in trachea and ileum of diabetic rats. Br J Pharmacol 135:1355-1362.
12. Dammann F, Fuder H, Giachetti A, Giraldo E, Kilbinger H, and Micheletti R (1989) AF-DX 116 differentiates between prejunctional muscarine receptors located on noradrenergic and cholinergic nerves. Naunyn-Schmiedeberg's Arch Pharmacol 339:268-271.
13. De Meyts P (1994) The structural basis of insulin and insulin-like growth factor-I receptor binding and negative co-operativity and its relevance to mitogenic versus metabolic signalling. Diabetologia 37 (Suppl 2):S135-S148.
14. De Meyts P, Wallach B, Christoffersen CT, Urso B, Gronskov K, Latus LJ, Yakushiji F, Ilondo MM, and Shymko RM (1994) The insulin-like growth factor-I receptor. Structure, ligand-binding mechanism and signal transduction. Horm Res 42:152-169.
15. Dunsmuir WD and Holmes SA (1996) The aetiology and management of erectile, ejaculatory and fertility problems in men with diabetes mellitus. Diabet Med 13:700-708.
16. Dupont J and LeRoith D (2001) Insulin and insulin-like growth factor I receptors: similarities and differences in signal transduction. Horm Res (Suppl 2):22-26.
17. Fryer AD and Maclagan J (1984) Muscarinic inhibitory receptors in pulmonary parasympathetic nerves in the guinea-pig. Br J Pharmacol 83:973-978.
18. Gallagher JT, Kent PW, Passatore M, Phipps RJ, and Richardson PS (1975) The composition of tracheal mucus and the nervous control of its secretion in the cat. Proc R Soc. Lond B Biol Sci 192:49-76.
19. Giraldo E, Micheletti R, Montagna E, Giachetti A, Vigano MA, Ladinsky H, and Melchiorre C (1988) Binding and functional characterization of the cardioselective muscarinic antagonist methoctramine. J Pharmacol Exp Ther 244:1016-1020.
20. Goyal RK (1988) Identification, localization and classification of muscarinic receptor subtypes in the gut. Life Sci 43:2209-2220.
21. Hadcock JR, Port JD, Gelman MS, and Malbon CC (1992) Cross-talk between tyrosine kinase and G-protein-linked receptors. Phosphorylation of beta 2-adrenergic receptors in response to insulin. J Biol Chem 267:26017-26022.
22. Hancock JC, Hoover DB, and Hougland MW (1987) Distribution of muscarinic receptors and acetylcholinesterase in the rat heart. J Auton Nerv Syst 19:59-66.
23. Holdengreber V, Ren Y, Ben Shaul Y, and Hausman RE (1998) Co-localization of the insulin receptor, jun protein and choline acetyltransferase in embryonic chick retina. Exp Eye Res 66:307-313.
24. Horowitz M and Fraser R (1994) Disordered gastric motor function in diabetes mellitus. Diabetologia 37:543-551.
25. Karagiannis SN, King RH, and Thomas PK (1997) Colocalisation of insulin and IGF-1 receptors in cultured rat sensory and sympathetic ganglion cells. J Anat 191:431-440.
26. Kilbinger H, Schneider R, Siefken H, Wolf D, and D'Agostino G (1991) Characterization of prejunctional muscarinic autoreceptors in the guinea-pig trachea. Br J Pharmacol 103:1757-1763.
27. Lambrecht G, Gross J, and Mutschler E (1999) Neuronal soma-dendritic and prejunctional M1-M4 receptors in gastrointestinal and genitourinary smooth muscle. Life Sci 64:403-410.
28. Lizcano JM and Alessi DR (2002) The insulin signalling pathway. Curr Biol 12: R236-R238.
29. Mak JCW and Barnes PJ (1990) Autoradiographic visualization of muscarinic receptor subtypes in human and guinea pig lung. Am Rev Respir Dis 141:1559-1568.
30. Minette PA and Barnes PJ (1988) Prejunctional inhibitory muscarinic receptors on cholinergic nerves in human and guinea pig airways. J Appl Physiol 64:2532-2537.
31. Nowak TV, Harrington B, Weisbruch JP, and Kalbfleisch JH (1990) Structural and functional characteristics of muscle from diabetic rodent small intestine. Am J Physiol 258:G690-G698.
32. Oberhauser V, Schwertfeger E, Rutz T, Beyersdorf F, and Rump LC (2001) Acetylcholine release in human heart atrium: influence of muscarinic autoreceptors, diabetes and age. Circulation 103:1638-1643.
33. Patel HJ, Barnes PJ, Takahashi T, Tadjkarimi S, Yacoub MH, and Belvisi MG (1995) Evidence for prejunctional muscarinic autoreceptors in human and guinea pig trachea. Am J Respir Crit Care Med 152:872-878.
34. Racke K, Hey C, and Wessler I (1992) Endogenous noradrenaline release from guinea-pig isolated trachea is inhibited by activation of M2 receptors. Br J Pharmacol 107:3-4.
35. Reinhardt RR, Chin E, Zhang B, Roth RA, and Bondy CA (1993) Insulin receptor-related receptor messenger ribonucleic acid is focally expressed in sympathetic and sensory neurons and renal distal tubule cells. Endocrinology 133:3-10.
36. Soltoff SP and Toker A (1995) Carbachol, substance P and phorbol ester promote the tyrosine phosphorylation of protein kinase C delta in salivary gland epithelial cells. J Biol Chem 270:13490-13495.
37. Somogyi GT and de Groat WC (1992) Evidence for inhibitory nicotinic and facilitatory muscarinic receptors in cholinergic nerve terminals of the rat urinary bladder. J Auton Nerv Syst 37:89-97.
38. Tobin G and Sjogren C (1995) In vivo and in vitro effects of muscarinic receptor antagonists on contractions and release of [3H] acetylcholine in the rabbit urinary bladder. Eur J Pharmacol 281:1-8.
39. Yokotani K and Osumi Y (1993) Cholinergic M2 muscarinic receptor-mediated inhibition of endogenous noradrenaline release from the isolated vascularly perfused rat stomach. J Pharmacol Exp Ther 264:54-60.