A practical, solvent free, one-pot synthesis of C2-symmetrical secondary amines

Tetrahedron Letters

Volumn 45, Issue 7, 2004, Pages 1449-1451

  Alexakis, Alexandre ^a   Gille, Ségolène ^a   Prian, Fabrice ^a   Rosset, Stéphane ^a   Ditrich, Klaus ^b  

^a UNIVERSITY OF GENEVA   (Switzerland)

^b BASF SE   (Germany)

Author keywords

C2 symmetry; Chiral amines; Reductive amination; Titanium isopropoxide

Indexed keywords

AMINE; SOLVENT;

ADDITION REACTION; AMINATION; ARTICLE; CHIRALITY; DIASTEREOISOMER; REDUCTION; SYNTHESIS;

EID: 1642578965     PISSN: 00404039     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.tetlet.2003.12.037     Document Type: Article

References (15)

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12. 4, and finally evaporated under reduced pressure.
13. 3) δ 24.8, 55.2, 124.7, 125.4, 125.9, 127.6, 127.7, 128.2, 132.7, 133.4, 143.0 ppm.
14. Amines 10 and 11 were characterized by comparison of their spectral data with those reported. For amine 10, see: Saudan, L. Ph.D. Dissertation 3013, University of Geneva, Geneva, 1998. For amine 11, see: Yamada H., Kawate T., Nishida A., Nakagawa M. J. Org. Chem. 64:1999;8821.
15. 4 is considered as nontoxic waste.