Multiple developmental roles of Ahnak are suggested by localization to sites of placentation and neural plate fusion in the mouse conceptus

Mechanisms of Development

Volumn 119, Issue SUPPL. 1, 2002, Pages

  Downs, Karen M ^a   McHugh, Jacalyn ^a   Copp, Andrew J ^b   Shtivelman, Emma ^c  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b UNIVERSITY COLLEGE LONDON   (United Kingdom)

^c UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

Ahnak; Allantois; Chorion; Ectoplacental cone; Extraembryonic mesoderm; Gastrulation; Giant cells; Invasion; Neural crest; Neural plate; Neural tube; Neurulation; Node; Placentation; Surface ectoderm; Trophoblast stem cells; Yolk sac

Indexed keywords

AHNAK; PHOSPHOPROTEIN; UNCLASSIFIED DRUG;

ANIMAL TISSUE; ARTICLE; CHORION; CONTROLLED STUDY; ECTODERM; EMBRYO; FETUS MEMBRANE; GIANT CELL; MORPHOGENESIS; MOUSE; NEURAL TUBE; NEUROECTODERM; NEURULATION; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; PROTEIN LOCALIZATION; REPRODUCTION; SYNCYTIOTROPHOBLAST; TROPHOBLAST; UTERUS; ANIMAL; FEMALE; GENE EXPRESSION REGULATION; HUMAN; METABOLISM; PREGNANCY;

ALLANTOIS; ANIMALS; ECTODERM; FEMALE; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HUMANS; MICE; NEURAL PLATE; PLACENTATION; PREGNANCY; TROPHOBLASTS;

EID: 1642576738     PISSN: 09254773     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0925-4773(03)00088-1     Document Type: Article

References (18)

1. Copp, A.J., Brook, F.A., Estibeiro, J.P., Shum, A.S.W., Cockroft, D.L., 1990. The embryonic development of mammalian neural tube defects. Prog. Neurobiol. 35, 363-403.
2. Downs, K.M., 2002. Early placentation in the mouse. Placenta 23, 116-131.
3. Downs, K.M., Davies, T., 1993. Staging of gastrulation in mouse embryos by morphological landmarks in the dissection microscope. Development 118, 1255-1266.
4. Downs, K.M., Gardner, R.L., 1995. An investigation into early placental ontogeny: allantoic attachment to the chorion is selective and developmentally regulated. Development 121, 407-416.
5. Downs, K.M., Gifford, S., Blahnik, M., Gardner, R.L., 1998. The murine allantois undergoes vasculogenesis that is not accompanied by erythropoiesis. Development 125, 4507-4521.
6. Downs, K.M., Harmann, C., 1997. Developmental potency of the murine allantois. Development 124, 2769-2780.
7. Downs, K.M., Temkin, R., Gifford, S., McHugh, J., 2001. Study of the murine allantois by allantoic explants. Dev. Biol. 233, 347-364.
8. Hashimoto, T., Amagai, M., Parry, D.A.D., Dixon, T.W., Tsukita, S., Tsukita, S., Miki, K., Sakai, K., Inokuchi, Y., Kudoh, J., Shimizu, N., Nishikawa, T., 1993. Desmoyokin, a 680 kDa keratinocyte plasma membrane-associated protein, is homologous to the protein encoded by human gene AHNAK. J. Cell Sci. 105, 275-286.
9. Hieda, Y., Tsukita, S., Tsukita, S., 1989. A new high molecular mass protein showing unique localization in desmosomal plaque. J. Cell Biol. 109, 1511-1518.
10. Kingsley, P.D., McGrath, K.E., Maltby, K.M., Koniski, A.D., Ramchandran, R., Palis, J., 2001. Subtractive hybridization reveals tissue-specific expression of ahnak during embryonic development. Dev. Growth Differ. 43, 133-143.
11. Lawson, K.A., Meneses, J.J., Pedersen, R.A., 1986. Cell fate and cell lineage in the endoderm of the presomite mouse embryo, studied with an intracellular tracer. Dev. Biol. 115, 325-339.
12. Lawson, K.A., Pedersen, R.A., 1987. Cell fate, morphogenetic movement and population kinetics of embryonic endoderm at the time of germ layer formation in the mouse. Development 101, 627-652.
13. Masunaga, T., Shimizu, H., Ishiko, A., Fujiwara, T., Hasimoto, T., Nishikawa, T., 1995. Desmoyokin/AHNAK protein localizes to the nondesmosomal keratinocyte cell surface of human epidermis. J. Invest. Dermatol. 104, 941-945.
14. Nie, Z., Ning, W., Amagai, M., Hashimoto, K., 2000. C-terminus of desmoyokin/AHNAK protein is responsible for its translocation between the nucleus and cytoplasm. J. Invest. Dermatol. 114, 1044-1049.
15. Shtivelman, E., Bishop, J.M., 1992. A human gene (AHNAK) encoding an unusually large protein with a 1.2 μm polyionic rod structure. Proc. Natl. Acad. Sci. USA 89, 5472-5476.
16. Shtivelman, E., Bishop, J.M., 1993. The human gene AHNAK encodes a large phosphoprotein located primarily in the nucleus. J. Cell Biol. 120, 625-630.
17. Shum, A.S.W., Copp, A.J., 1996. Regional differences in morphogenesis of the neuropeithelium suggest multiple mechanisms of spinal neurulation in the mouse. Anat. Embryol. 194, 65-73.
18. Sussman, J., Stokoe, D., Ossina, N., Shtivelman, E., 2001. Protein kinase B phosphorylates AHNAK and regulates its subcellular localization. J. Cell Biol. 154, 1019-1030.