Toxicity of prednisolone, dexamethasone and their photochemical derivatives on aquatic organisms

Chemosphere

Volumn 54, Issue 5, 2004, Pages 629-637

  DellaGreca, Marina ^a   Fiorentino, Antonio ^b   Isidori, Marina ^b   Lavorgna, Margherita ^b   Previtera, Lucio ^a   Rubino, Maria ^a   Temussi, Fabio ^a  

^a UNIVERSITY OF NAPLES FEDERICO II   (Italy)

^b II Università   (Italy)

Author keywords

Acute and chronic toxicity; Dexamethasone; Phototransformation; Prednisolone

Indexed keywords

DRUG PRODUCTS PLANTS; PHOTOCHEMICAL FORMING; SPECTROMETERS; TOXICITY;

PHOTOTRANSFORMATION;

ORGANIC COMPOUNDS;

DEXAMETHASONE; PREDNISOLONE;

AQUATIC ENVIRONMENT; ORGANIC COMPOUND; PHOTODEGRADATION; TOXICITY TEST;

ACUTE TOXICITY; AQUATIC ENVIRONMENT; AQUATIC FAUNA; ARTICLE; CHRONIC TOXICITY; DERIVATIZATION; ENVIRONMENTAL IMPACT; GROWTH INHIBITION; LIGHT EXPOSURE; MICROORGANISM; PHOTOCHEMISTRY; POPULATION GROWTH; TOXICITY TESTING;

ALGAE; ANOSTRACA; BRACHIONUS; BRACHIONUS CALYCIFLOROUS; BRACHIONUS CALYCIFLORUS; CERIODAPHNIA DUBIA; CLADOCERA; CRUSTACEA; DAPHNIA; DAPHNIA MAGNA; PSEUDOKIRCHNERIELLA SUBCAPITATA; SELENASTRUM; SELENASTRUM CAPRICORNUTUM; THAMNOCEPHALUS; THAMNOCEPHALUS PLATYURUS;

EID: 1642576031     PISSN: 00456535     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2003.09.008     Document Type: Article

References (17)

1. Aherne, G.W., Briggs, R., 1989. The relevance of the presence of certain synthetic steroids in the aquatic environment. J. Pharm. Pharmacol. 41, 735-736.
2. American Society for Testing and Materials, 1991. Standard guide for acute toxicity with the rotifer Brachionus. E 1440-91 (reapproved 1998). Philadelphia, PA, USA.
3. Daughton, C.G., Ternes, T.A., 1999. Special report: pharmaceuticals and personal care products in the environment: agents of subtle change? Environ. Health Perspect. 107, 907-938.
4. DellaGreca, M., Fiorentino, A., Iesce, MR., Isidori, M., Nardelli, A., Previtera, L., Temussi, A., 2003. Identification of phototransformation products of prednisone by sunlight. Toxicity of the drug and its derivatives on aquatic organisms. Environ. Toxicol. Chem. 22, 534-539.
5. Halling-Sorensen, B., Nors Nielsen, S., Lanzky, P.F., Ingerslev, F., Holten Lützhoft, H.C., Jorgensen, S.E., 1998. Occurrence, fate and effects of pharmaceutical substances in the environment - a review. Chemosphere 36, 357-393.
6. International Organization for Standardization, 1987. Water quality-algal growth inhibition test. ISO/DIS 8692. Geneva, Switzerland.
7. International Organization for Standardization, 1996. Water quality-determination of the inhibition of the mobility of Daphnia magna Straus (Cladocera, Crustacea) Acute toxicity test. ISO/6341. Geneva, Switzerland.
8. International Organization for Standardization, 2001. Water quality-determination of chronic toxicity to Ceriodaphnia dubia in 7 days-Population growth inhibition test. ISO/CD 20665. Geneva, Switzerland.
9. Jones, O.A.H., Voulvoulis, N., Lester, J.N., 2002. Aquatic environmental assessment of the top 25 English prescription pharmaceuticals. Water Res. 36, 5013-5022.
10. Maayan, R., Segal, R., Feuerman, E.J., Sandbank, M., Kaufman, H., 1988. Simple methods for estimation of prednisone intake and metabolism. Biomed. Pharmacother. 42, 409-414.
11. Peltier, W.H., Weber, C.I. (Eds.) 1985. Methods for measuring the acute toxicity of effluents to freshwater and marine organisms. EPA-600/4-85-013. US Environmental Protection Agency, Washington, DC, USA.
12. Raloff, J., 1998. Drugged waters. Sci. News 153 (12), 187-189.
13. Takacs, M., Ekiz-Gucer, N., Reisch, J., Gergeli-Zobin, A., 1991. The light sensitivity of corticosteroids in crystalline form. Photochemical studies. 59. Pharm Acta Helv. 66, 137-140.
14. Ternes, T.A., Wilken, R.D., 1999. Drugs and hormones as pollutants of the aquatic environment: determination and ecotoxicological impacts. Sci. Total Environ. 225 (1-2), 1-176.
15. Toxicity Data Analysis and Database Software (Toxcalc™), (vers. 5.0). 1996. Tidepool Scientific Software and Michael A. Ives, Mckinleyville, CA, USA.
16. Williams, J.R., Moore, R.H., Li, R., Blount, J.F., 1979. Structure and photochemistry of lumiprednisone acetate. J. Am. Chem. Soc. 101, 5019-5025.
17. Zuccato, E., Calamari, D., Natangelo, M., Fanelli, R., 2000. Presence of therapeutic drugs in the environment. Lancet 355, 1720-1789.