Synthesis and antibiotic activity of the tricyclic furo[3,2-c] isochromen-2-trione unit of the pyranonaphthoquinones

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 3, 2004, Pages 757-760

  Bianchi, Darío A ^a   Sutich, Emma G ^b   Kaufman, Teodoro S ^a  

^a Universidad Nacional de Rosario   (Argentina)

^b UNIVERSIDAD NACIONAL DE ROSARIO   (Argentina)

Author keywords

[No Author keywords available]

Indexed keywords

3,3A,5,9B TETRAHYDROFURO[3,2 C]ISOCHROMEN 2 TRIONE; CHROMENE DERIVATIVE; NAPHTHOQUINONE; UNCLASSIFIED DRUG;

ANTIMICROBIAL ACTIVITY; ARTICLE; BACILLUS SUBTILIS; CATALYSIS; DRUG SYNTHESIS; LACTONIZATION; MICHAEL ADDITION; MINIMUM INHIBITORY CONCENTRATION; NONHUMAN; PHARMACOPHORE; STAPHYLOCOCCUS AUREUS; WITTIG REACTION;

BACILLUS SUBTILIS; STAPHYLOCOCCUS; STAPHYLOCOCCUS AUREUS;

EID: 1642575086     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.015     Document Type: Article

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43. 8 CFU/mL) were prepared and spread over Mueller-Hinton agar plates. After 3 min at rt, 6 mm disks (prepared by adding known amounts of test compound in MeOH and allowing to dry at rt) with various amounts of test substance were placed at distances of 24 mm to each other and incubated at rt for periods of 15 or 120 min, after which they were incubated at 37 °C for 24 h, when inhibition haloes were measured.
44. Working solutions (256 μg/mL) were prepared by dilution of stock solutions (2000 μg/mL in MeOH) with Mueller-Hinton broth. The bacterial innoculum was a 1/10 dilution of a bacterial suspension (grown overnight in brain hearth broth), adjusted to 0.5 in the Mc Farland turbidity scale. Serial dilutions of the working solutions were added to different tubes containing the bacterial suspension and the tubes were incubated during 24 h at 37°C. MIC is the minimum concentration of the substance which avoids production of turbidity, while MBC is the minimum concentration of the tested substance which kills at least 99% of the bacterial population.