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Volumn 81, Issue 6, 2003, Pages 459-471

Enhancing CTL responses to melanoma cell vaccines in vivo: Synergistic increases obtained using IFNγ primed and IFNβ treated B7-1 + B16-F10 melanoma cells

Author keywords

Antigen presentation; Costimulation; CTL response; Cytokines; Interferons; Melanoma; Tumour immunity; Vaccination

Indexed keywords

B7 ANTIGEN; BETA INTERFERON; CANCER VACCINE; GAMMA INTERFERON; INTERCELLULAR ADHESION MOLECULE 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1;

EID: 1642546952     PISSN: 08189641     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.0818-9641.2003.01189.x     Document Type: Article
Times cited : (19)

References (50)
  • 1
    • 1642521824 scopus 로고    scopus 로고
    • Use of cytokines in cancer vaccines/immunotherapy: Recent developments improve survival rates for patients with metastatic malignancy
    • In press
    • Dezfouli S, Hatzinisiriou I, Ralph SJ. Use of cytokines in cancer vaccines/immunotherapy: recent developments improve survival rates for patients with metastatic malignancy. Curr. Pharm. Des. 2004. In press.
    • (2004) Curr. Pharm. Des.
    • Dezfouli, S.1    Hatzinisiriou, I.2    Ralph, S.J.3
  • 2
    • 0028500836 scopus 로고
    • Enhanced in vivo growth and resistance to rejection of tumour cells expressing dominant negative IFN gamma receptors
    • Dighe AS, Richards E, Old LJ, Schreiber RD. Enhanced in vivo growth and resistance to rejection of tumour cells expressing dominant negative IFN gamma receptors. Immunity 1994; 1: 447-56.
    • (1994) Immunity , vol.1 , pp. 447-456
    • Dighe, A.S.1    Richards, E.2    Old, L.J.3    Schreiber, R.D.4
  • 3
    • 0032560475 scopus 로고    scopus 로고
    • Demonstration of an interferon gamma-dependent tumour surveillance system in immunocompetent mice
    • Kaplan DH, Shankaran V, Dighe AS et al. Demonstration of an interferon gamma-dependent tumour surveillance system in immunocompetent mice. Proc. Natl Acad. Sci. USA 1998; 95: 7556-61.
    • (1998) Proc. Natl. Acad. Sci. USA , vol.95 , pp. 7556-7561
    • Kaplan, D.H.1    Shankaran, V.2    Dighe, A.S.3
  • 4
    • 0035953308 scopus 로고    scopus 로고
    • IFN-gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity
    • Shankaran V, Ikeda H, Bruce AT et al. IFN-gamma and lymphocytes prevent primary tumour development and shape tumour immunogenicity. Nature 2001; 410: 1107-11.
    • (2001) Nature , vol.410 , pp. 1107-1111
    • Shankaran, V.1    Ikeda, H.2    Bruce, A.T.3
  • 6
    • 0022909190 scopus 로고
    • Expression and susceptibility to modulation by interferons of HLA class I and II antigens on melanoma cells. Immunohistochemical analysis and clinical relevance
    • Ruiter DJ, Brocker EB, Ferrone S. Expression and susceptibility to modulation by interferons of HLA class I and II antigens on melanoma cells. Immunohistochemical analysis and clinical relevance. J. Immunogenet 1986; 13: 229-34.
    • (1986) J. Immunogenet , vol.13 , pp. 229-234
    • Ruiter, D.J.1    Brocker, E.B.2    Ferrone, S.3
  • 7
    • 0027957398 scopus 로고
    • HLA class I heavy-chain gene promoter elements mediating synergy between tumour necrosis factor and IFNs
    • Johnson DR, Pober JS. HLA class I heavy-chain gene promoter elements mediating synergy between tumour necrosis factor and IFNs. Mol. Cell. Biol. 1994; 14: 1322-32.
    • (1994) Mol. Cell. Biol. , vol.14 , pp. 1322-1332
    • Johnson, D.R.1    Pober, J.S.2
  • 9
    • 0027330942 scopus 로고
    • A regulatory element in the beta 2-microglobulin promoter identified by in vivo footprinting
    • Lonergan M, Dey A, Becker KO, Drew PD, Ozato K. A regulatory element in the beta 2-microglobulin promoter identified by in vivo footprinting. Mol. Cell Biol. 1993; 13: 6629-39.
    • (1993) Mol. Cell Biol. , vol.13 , pp. 6629-6639
    • Lonergan, M.1    Dey, A.2    Becker, K.O.3    Drew, P.D.4    Ozato, K.5
  • 11
    • 0030904284 scopus 로고    scopus 로고
    • Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86) on human hepatocellular carcinoma
    • Tatsumi T, Takehara T, Katayama K et al. Expression of costimulatory molecules B7-1 (CD80) and B7-2 (CD86) on human hepatocellular carcinoma. Hepatology 1997; 25: 1108-14.
    • (1997) Hepatology , vol.25 , pp. 1108-1114
    • Tatsumi, T.1    Takehara, T.2    Katayama, K.3
  • 12
    • 0030982421 scopus 로고    scopus 로고
    • The heterogeneous expression of CD80, CD86 and other adhesion molecules on leukemia and lymphoma cells and their induction by IFN
    • Tsukada N, Aoki S, Maruyama S, Kishi K, Takahashi M, Aizawa Y. The heterogeneous expression of CD80, CD86 and other adhesion molecules on leukemia and lymphoma cells and their induction by IFN. J. Exp. Clin. Cancer Res. 1997; 16: 171-6.
    • (1997) J. Exp. Clin. Cancer Res. , vol.16 , pp. 171-176
    • Tsukada, N.1    Aoki, S.2    Maruyama, S.3    Kishi, K.4    Takahashi, M.5    Aizawa, Y.6
  • 13
    • 0029979838 scopus 로고    scopus 로고
    • IFN-alpha induced autoimmune T-cells through the induction of intracellular adhesion molecule-1 and B72
    • Chakrabarti D, Hultgren B, Stewart TA. IFN-alpha induced autoimmune T-cells through the induction of intracellular adhesion molecule-1 and B72. J. Immunol. 1996; 157: 522-8.
    • (1996) J. Immunol. , vol.157 , pp. 522-528
    • Chakrabarti, D.1    Hultgren, B.2    Stewart, T.A.3
  • 15
    • 0032102991 scopus 로고    scopus 로고
    • IFN-gamma-priming up-regulates ISGF3 components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs
    • Wong LH, Hatzinisiriou I, Devenish RJ, Ralph SJ. IFN-gamma-priming up-regulates ISGF3 components, augmenting responsiveness of IFN-resistant melanoma cells to type I IFNs. J. Immunol. 1998; 160: 5475-84.
    • (1998) J. Immunol. , vol.160 , pp. 5475-5484
    • Wong, L.H.1    Hatzinisiriou, I.2    Devenish, R.J.3    Ralph, S.J.4
  • 17
    • 0018451169 scopus 로고
    • Cancer metastasis
    • Nicolson GL. Cancer metastasis. Sci. Am. 1979; 240: 66-76.
    • (1979) Sci. Am. , vol.240 , pp. 66-76
    • Nicolson, G.L.1
  • 18
    • 0020629842 scopus 로고
    • Demonstration of immunogenicity with the poorly immunogenic B16 melanoma
    • Celik C, Lewis DA, Goldrosen MH. Demonstration of immunogenicity with the poorly immunogenic B16 melanoma. Cancer Res. 1983; 43: 3507-10.
    • (1983) Cancer Res. , vol.43 , pp. 3507-3510
    • Celik, C.1    Lewis, D.A.2    Goldrosen, M.H.3
  • 19
    • 0027538181 scopus 로고
    • Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity
    • Dranoff G, Jaffee E, Lazenby A et al. Vaccination with irradiated tumor cells engineered to secrete murine granulocyte-macrophage colony-stimulating factor stimulates potent, specific, and long-lasting anti-tumor immunity. Proc. Natl Acad. Sci. USA 1993; 90: 3539-43.
    • (1993) Proc. Natl. Acad. Sci. USA , vol.90 , pp. 3539-3543
    • Dranoff, G.1    Jaffee, E.2    Lazenby, A.3
  • 20
    • 0028341476 scopus 로고
    • Partial purification of murine tumor-associated peptide epitopes common to histologically distinct tumors, melanoma and sarcoma, that are presented by H-2Kb molecules and recognized by CD8+ tumor-infiltrating lymphocytes
    • Itoh T, Storkus WJ, Gorelik E, Lotze MT. Partial purification of murine tumor-associated peptide epitopes common to histologically distinct tumors, melanoma and sarcoma, that are presented by H-2Kb molecules and recognized by CD8+ tumor-infiltrating lymphocytes. J. Immunol. 1994; 153: 1202-15.
    • (1994) J. Immunol. , vol.153 , pp. 1202-1215
    • Itoh, T.1    Storkus, W.J.2    Gorelik, E.3    Lotze, M.T.4
  • 21
    • 0028979117 scopus 로고
    • Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response
    • Cavallo F, Martin-Fontecha A, Bellone M et al. Co-expression of B7-1 and ICAM-1 on tumors is required for rejection and the establishment of a memory response. Eur. J. Immunol. 1995; 25: 1154-62.
    • (1995) Eur. J. Immunol. , vol.25 , pp. 1154-1162
    • Cavallo, F.1    Martin-Fontecha, A.2    Bellone, M.3
  • 23
    • 0030588613 scopus 로고    scopus 로고
    • CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T-cell lysis
    • Nishio M, Spielman JM, Lee RK, Nelson DL, Podack ER. CD80 (B7. 1) and CD54 (intracellular adhesion molecule-1) induce target cell susceptibility to promiscuous cytotoxic T-cell lysis. J. Immunol. 1996; 157: 4347-53.
    • (1996) J. Immunol. , vol.157 , pp. 4347-4353
    • Nishio, M.1    Spielman, J.M.2    Lee, R.K.3    Nelson, D.L.4    Podack, E.R.5
  • 24
    • 0031049932 scopus 로고    scopus 로고
    • B16 melanoma cells exposed in vitro to long-term IFN-α treatment (B16a cells) as activators of tumor immunity in mice
    • Fleischmann CM, Wu TY, Fleischmann WR Jr. B16 melanoma cells exposed in vitro to long-term IFN-α treatment (B16a cells) as activators of tumor immunity in mice. J. Interferon Cytokine Res. 1997; 17: 37-43.
    • (1997) J. Interferon Cytokine Res. , vol.17 , pp. 37-43
    • Fleischmann, C.M.1    Wu, T.Y.2    Fleischmann Jr., W.R.3
  • 25
    • 0031770534 scopus 로고    scopus 로고
    • Efficacy of B16 melanoma cells exposed in vitro to long-term IFN-alpha treatment (B16alpha cells) as a tumor vaccine in mice
    • Wu TY, Fleischmann WR Jr. Efficacy of B16 melanoma cells exposed in vitro to long-term IFN-alpha treatment (B16alpha cells) as a tumor vaccine in mice. J. Interferon Cytokine Res. 1998; 18: 829-39.
    • (1998) J. Interferon Cytokine Res. , vol.18 , pp. 829-839
    • Wu, T.Y.1    Fleischmann Jr., W.R.2
  • 26
    • 0026047949 scopus 로고
    • Effects of interferon-gamma and tumour necrosis factor-alpha on the development of cytotoxic T lymphocytes in autologous mixed lymphocyte tumour cultures with human melanoma
    • Roth AD, Hornicek FJ, Gerstner CG, Kirkwood JM. Effects of interferon-gamma and tumour necrosis factor-alpha on the development of cytotoxic T lymphocytes in autologous mixed lymphocyte tumour cultures with human melanoma. Clin. Exp. Immunol. 1991; 86: 163-72.
    • (1991) Clin. Exp. Immunol. , vol.86 , pp. 163-172
    • Roth, A.D.1    Hornicek, F.J.2    Gerstner, C.G.3    Kirkwood, J.M.4
  • 27
    • 0034020397 scopus 로고    scopus 로고
    • Interferon-alpha (IFN-α) stimulates anti-melanoma cytotoxic T lymphocyte (CTL) generation in mixed lymphocyte tumour cultures (MLTC)
    • Palmer KJ, Harries M, Gore ME, Collins MK. Interferon-alpha (IFN-α) stimulates anti-melanoma cytotoxic T lymphocyte (CTL) generation in mixed lymphocyte tumour cultures (MLTC). Clin. Exp. Immunol. 2000; 119: 412-8.
    • (2000) Clin. Exp. Immunol. , vol.119 , pp. 412-418
    • Palmer, K.J.1    Harries, M.2    Gore, M.E.3    Collins, M.K.4
  • 28
    • 0027284389 scopus 로고
    • Detection of melanoma-reactive CD4+ HLA-class I-restricted cytotoxic T-cell clones with long-term assay and pretreatment of targets with interferon-gamma
    • LeMay LG, Kan-Mitchell J, Goedegeburre P, Harel W, Mitchell MS. Detection of melanoma-reactive CD4+ HLA-class I-restricted cytotoxic T-cell clones with long-term assay and pretreatment of targets with interferon-gamma. Cancer Immunol. Immunother. 1993; 37: 187-94.
    • (1993) Cancer Immunol. Immunother. , vol.37 , pp. 187-194
    • LeMay, L.G.1    Kan-Mitchell, J.2    Goedegeburre, P.3    Harel, W.4    Mitchell, M.S.5
  • 29
    • 8944263300 scopus 로고    scopus 로고
    • Differential modulation by interferon gamma of the sensitivity of human melanoma cells to cytolytic T-cell clones that recognize differentiation or progression antigens
    • Kirkin AF, thor Straten P, Zeuthen J. Differential modulation by interferon gamma of the sensitivity of human melanoma cells to cytolytic T-cell clones that recognize differentiation or progression antigens. Cancer Immunol. Immunother. 1996; 42: 203-12.
    • (1996) Cancer Immunol. Immunother. , vol.42 , pp. 203-212
    • Kirkin, A.F.1    Thor Straten, P.2    Zeuthen, J.3
  • 30
    • 0026091380 scopus 로고
    • Mice lacking MHC class II molecules
    • Cosgrove D, Gray D, Dierich A et al. Mice lacking MHC class II molecules. Cell 1991; 66: 1051-66.
    • (1991) Cell , vol.66 , pp. 1051-1066
    • Cosgrove, D.1    Gray, D.2    Dierich, A.3
  • 31
    • 0344887640 scopus 로고
    • Tissue culture studies on human malignant melanoma
    • McGovern, VJ, Russell, P, eds. S. Karger Press
    • Whitehead RH, Little JH. Tissue culture studies on human malignant melanoma. In: McGovern, VJ, Russell, P, eds. Pigment T-cell, Vol. 1. Basel (Switzerland). S. Karger Press 1973; 382-9.
    • (1973) Pigment T-cell, Vol. 1. Basel (Switzerland) , vol.1 , pp. 382-389
    • Whitehead, R.H.1    Little, J.H.2
  • 32
    • 0025369992 scopus 로고
    • TGATG vector: A new expression system for cloned foreign genes in Escherichia coli cells
    • Mashko SV, Veiko VP, Lapidus AL et al. TGATG vector: a new expression system for cloned foreign genes in Escherichia coli cells. Gene 1990; 88: 121-6.
    • (1990) Gene , vol.88 , pp. 121-126
    • Mashko, S.V.1    Veiko, V.P.2    Lapidus, A.L.3
  • 33
    • 0023726619 scopus 로고
    • Interferons in rheumatoid arthritis: Alterations in production and response related to disease activity
    • Hertzog PJ, Emery P, Cheetham BF, Mackay IR, Linnane AW. Interferons in rheumatoid arthritis: alterations in production and response related to disease activity. Clin. Immunol. Immunopathol. 1988; 48: 192-201.
    • (1988) Clin. Immunol. Immunopathol. , vol.48 , pp. 192-201
    • Hertzog, P.J.1    Emery, P.2    Cheetham, B.F.3    Mackay, I.R.4    Linnane, A.W.5
  • 34
    • 1642521825 scopus 로고
    • In vitro assays for mouse lymphocyte function
    • Coligan, JE, Kruisbeek, AM, Margulies, DH, Shevach, EM, Strober, E, eds. New York: Greene Publications, Associates and Wiley-Interscience Press
    • Wunderlich J, Shearer G. In vitro assays for mouse lymphocyte function. In: Coligan, JE, Kruisbeek, AM, Margulies, DH, Shevach, EM, Strober, E, eds. Current Protocols in Immunology. New York: Greene Publications, Associates and Wiley-Interscience Press, 1993; 11-14.
    • (1993) Current Protocols in Immunology , pp. 11-14
    • Wunderlich, J.1    Shearer, G.2
  • 35
    • 0032101927 scopus 로고    scopus 로고
    • Two types of anti-TL (thymus leukemia) CTL clones with distinct target specificities: Differences in cytotoxic mechanisms and accessory molecule requirements
    • Tsujimura K, Takahashi T, Iwase S et al. Two types of anti-TL (thymus leukemia) CTL clones with distinct target specificities: differences in cytotoxic mechanisms and accessory molecule requirements. J. Immunol. 1998; 160: 5253-61.
    • (1998) J. Immunol. , vol.160 , pp. 5253-5261
    • Tsujimura, K.1    Takahashi, T.2    Iwase, S.3
  • 36
    • 0034176232 scopus 로고    scopus 로고
    • Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4+ as well as CD8+ cytotoxic T lymphocytes in humans
    • Yasukawa M, Ohminami H, Arai J, Kasahara Y, Ishida Y, Fujita S. Granule exocytosis, and not the Fas/Fas ligand system, is the main pathway of cytotoxicity mediated by alloantigen-specific CD4+ as well as CD8+ cytotoxic T lymphocytes in humans. Blood 2000; 95: 2352-5.
    • (2000) Blood , vol.95 , pp. 2352-2355
    • Yasukawa, M.1    Ohminami, H.2    Arai, J.3    Kasahara, Y.4    Ishida, Y.5    Fujita, S.6
  • 37
    • 0035422733 scopus 로고    scopus 로고
    • Heterogeneity of channel catfish CTL with respect to target recognition and cytotoxic mechanisms employed
    • Zhou H, Stuge TB, Miller NW et al. Heterogeneity of channel catfish CTL with respect to target recognition and cytotoxic mechanisms employed. J. Immunol. 2001; 167: 1325-32.
    • (2001) J. Immunol. , vol.167 , pp. 1325-1332
    • Zhou, H.1    Stuge, T.B.2    Miller, N.W.3
  • 38
  • 39
    • 0030584849 scopus 로고    scopus 로고
    • Tumour rejection requires a CTLA4 ligand provided by the host or expressed on the tumour. Superiority of B7-1 over B7-2 for active tumour immunization
    • Gajewski TF, Fallarino F, Uyttenhove C, Boon T. Tumour rejection requires a CTLA4 ligand provided by the host or expressed on the tumour. Superiority of B7-1 over B7-2 for active tumour immunization. J. Immunol. 1996; 156: 2909-17.
    • (1996) J. Immunol. , vol.156 , pp. 2909-2917
    • Gajewski, T.F.1    Fallarino, F.2    Uyttenhove, C.3    Boon, T.4
  • 40
    • 0029864363 scopus 로고    scopus 로고
    • Does B7-1 expression confer antigen-presenting cell capacity to tumours in vivo?
    • Huang AY, Bruce AT, Pardoll DM, Levitsky HI. Does B7-1 expression confer antigen-presenting cell capacity to tumours in vivo? J. Exp. Med. 1996; 183: 769-76.
    • (1996) J. Exp. Med. , vol.183 , pp. 769-776
    • Huang, A.Y.1    Bruce, A.T.2    Pardoll, D.M.3    Levitsky, H.I.4
  • 41
    • 0030792796 scopus 로고    scopus 로고
    • Protective and therapeutic immunity against leukemia induced by irradiated B7-1 (CD80) -transduced leukemic cells
    • Hirano N, Takahashi T, Takahashi T et al. Protective and therapeutic immunity against leukemia induced by irradiated B7-1 (CD80) -transduced leukemic cells. Hum. Gene Ther. 1997; 8: 1375-84.
    • (1997) Hum. Gene Ther. , vol.8 , pp. 1375-1384
    • Hirano, N.1    Takahashi, T.2    Takahashi, T.3
  • 42
    • 0034649643 scopus 로고    scopus 로고
    • Information transfer at the immunological synapse
    • Delon J, Germain RN. Information transfer at the immunological synapse. Curr. Biol. 2000; 10: R923-33.
    • (2000) Curr. Biol. , vol.10
    • Delon, J.1    Germain, R.N.2
  • 43
    • 0033980716 scopus 로고    scopus 로고
    • From synapses to immunological memory: The role of sustained T-cell stimulation
    • Lanzavecchia A, Sallusto F. From synapses to immunological memory: the role of sustained T-cell stimulation. Curr. Opin. Immunol. 2000; 12: 92-7.
    • (2000) Curr. Opin. Immunol. , vol.12 , pp. 92-97
    • Lanzavecchia, A.1    Sallusto, F.2
  • 44
    • 0034292398 scopus 로고    scopus 로고
    • Cytototoxic T-cells specifically induce Fas on target cells, thereby facilitating exocytosis-independent induction of apoptosis
    • Simon MM, Waring P, Lobigs M et al. Cytototoxic T-cells specifically induce Fas on target cells, thereby facilitating exocytosis-independent induction of apoptosis. J. Immunol. 2000; 165: 3663-72.
    • (2000) J. Immunol. , vol.165 , pp. 3663-3672
    • Simon, M.M.1    Waring, P.2    Lobigs, M.3
  • 46
    • 0032880649 scopus 로고    scopus 로고
    • Human tumor antigens for cancer vaccine development
    • Wang RF, Rosenberg SA. Human tumor antigens for cancer vaccine development. Immunol. Rev. 1999; 170: 85-100.
    • (1999) Immunol. Rev. , vol.170 , pp. 85-100
    • Wang, R.F.1    Rosenberg, S.A.2
  • 47
    • 0035985655 scopus 로고    scopus 로고
    • Cancer vaccines, a critical review - Part I
    • Mitchell MS. Cancer vaccines, a critical review - Part I. Curr. Opin. Invest. Drugs 2002; 3: 140-9.
    • (2002) Curr. Opin. Invest. Drugs , vol.3 , pp. 140-149
    • Mitchell, M.S.1
  • 48
    • 0036283493 scopus 로고    scopus 로고
    • Active immunotherapy by reinduction with a polyvalent allogeneic cell vaccine correlates with improved survival in recurrent metastatic melanoma
    • Hsueh EC, Essner R, Foshag LJYeW, Morton DL. Active immunotherapy by reinduction with a polyvalent allogeneic cell vaccine correlates with improved survival in recurrent metastatic melanoma. Ann. Surg. Oncol. 2002; 9: 486-92.
    • (2002) Ann. Surg. Oncol. , vol.9 , pp. 486-492
    • Hsueh, E.C.1    Essner, R.2    Foshag, L.J.Ye.W.3    Morton, D.L.4
  • 49
    • 0027994493 scopus 로고
    • Expression of the costimulatory molecule B7 on melanoma cells
    • Hersey P, Si Z, Smith MJ, Thomas WD. Expression of the costimulatory molecule B7 on melanoma cells. Int. J. Cancer 1994; 58: 527-31.
    • (1994) Int. J. Cancer , vol.58 , pp. 527-531
    • Hersey, P.1    Si, Z.2    Smith, M.J.3    Thomas, W.D.4
  • 50
    • 0344500704 scopus 로고    scopus 로고
    • Potent activity of soluble B7-IgG fusion proteins in therapy of established tumors and as vaccine adjuvant
    • Sturmhoefel K, Lee K, Gray GS et al. Potent activity of soluble B7-IgG fusion proteins in therapy of established tumors and as vaccine adjuvant. Cancer Res. 1999; 59: 4964-72.
    • (1999) Cancer Res. , vol.59 , pp. 4964-4972
    • Sturmhoefel, K.1    Lee, K.2    Gray, G.S.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.