Role of transient receptor potential canonical 6 (TRPC6) in non-transferrin-bound iron uptake in neuronal phenotype PC12 cells

Biochemical Journal

Volumn 378, Issue 3, 2004, Pages 975-982

  Mwanjewe, James ^a   Grover, Ashok K ^a  

^a MCMASTER UNIVERSITY   (Canada)

Author keywords

Calcium channel; Nerve growth factor; Non transferrin bound iron; Parkinson's disease; PC12 cell; Transient receptor potential canonical 6 (TRPC6)

Indexed keywords

BIOCHEMISTRY; CELLS; FLUORESCENCE; PROTEINS; RNA; TOXICITY;

NEUROTOXICITY;

CYTOLOGY;

ALPHA 1 ADRENERGIC RECEPTOR; CALCEIN; CALCIUM CHANNEL; CALCIUM ION; DIACYLGLYCEROL; IRON; NATURAL RESISTANCE ASSOCIATED MACROPHAGE PROTEIN 2; NERVE GROWTH FACTOR; NON TRANSFERRIN BOUND IRON; PHENYLEPHRINE; PROTEIN; TRANSFERRIN; TRANSIENT RECEPTOR POTENTIAL CANONICAL 6; TRANSIENT RECEPTOR POTENTIAL CHANNEL; UNCLASSIFIED DRUG;

ANIMAL CELL; ARTICLE; CELL STRAIN; CLINICAL PATHWAY; CONTROLLED STUDY; EMBRYO; FLUORESCENCE; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IRON TRANSPORT; NEUROTOXICITY; NONHUMAN; NUCLEOTIDE SEQUENCE; PARKINSON DISEASE; PATHOGENESIS; PHENOTYPE; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT;

ANIMALS; BIOLOGICAL TRANSPORT; CALCIUM CHANNELS; CELL LINE; DIGLYCERIDES; HUMANS; IRON; NERVE GROWTH FACTOR; NEURONS; PC12 CELLS; PHENOTYPE; PHENYLEPHRINE; RATS; RNA, MESSENGER; TRANSFECTION; TRANSFERRIN; TRPC CATION CHANNELS;

ANIMALIA;

EID: 1642545649     PISSN: 02646021     EISSN: None     Source Type: Journal    
DOI: 10.1042/BJ20031187     Document Type: Article

References (44)

1. 2+ uptake by intracellular stores [review]. Pharmacol. Ther. 50, 191-232
2. 2+ channel essential for phosphoinositide-mediated photoreception, forms a signaling complex with NorpA, InaC and InaD. EMBO J. 15, 7036-7045
3. 2+ influx in stably transfected HEK-293 cells. FEBS Lett. 422, 333-338
4. McKay, R. R., Szymeczek-Seay, C. L., Lievremont, J. P., Bird, G. S., Zitt, C., Jungling, E., Luckhoff, A. and Putney, Jr, J. W. (2000) Cloning and expression of the human transient receptor potential 4 (TRP4) gene: localization and functional expression of human TRP4 and TRP3. Biochem. J. 351, 735-746
5. Montell, C., Birnbaumer, L., Flockerzi, V., Bindels, R. J., Bruford, E. A., Caterina, M. J., Clapham, D. E., Harteneck, C., Heller, S., Julius, D. et al. (2002) A unified nomenclature for the superfamily of TRP cation channels. Mol. Cell 9, 229-231
6. Hassock, S. R., Zhu, M. X., Trost, C., Flockerzi, V. and Authi, K. S. (2002) Expression and role of TRPC proteins in human platelets: evidence that TRPC6 forms the store-independent calcium entry channel. Blood 100, 2801-2811
7. Wu, X., Babnigg, G., Zagranichnaya, T. and Villereal, M. L. (2002) The role of endogenous human Trp4 in regulating carbachol-induced calcium oscillations in HEK-293 cells. J. Biol. Chem. 277, 13597-13608
8. 2+ channel isoforms. Molecular structures and functional characterization. J. Biol. Chem. 276, 13331-13339
9. Boulay, G., Zhu, X., Peyton, M., Jiang, M., Hurst, R., Stefani, E. and Birnbaumer, L. (1997) Cloning and expression of a novel mammalian homolog of Drosophila transient receptor potential (Trp) involved in calcium entry secondary to activation of receptors coupled by the Gq class of G protein. J. Biol. Chem. 272, 29672-29680
10. Hofmann, T, Obukhov, A. G., Schaefer, M., Harteneck, C., Gudermann, T. and Schultz, G. (1999) Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature (London) 397, 259-263
11. Sylvester, J. B., Mwanjewe, J. and Grover, A. K. (2001) Transient receptor potential protein mRNA expression in rat substantia nigra. Neurosci. Lett. 300, 83-86
12. 2+-sensitive cation channels. J. Biol. Chem. 275, 27799-27805
13. 2+ entry in human neutrophils induced by thapsigargin. Cell Calcium 10, 477-490
14. 2+ entry. J. Biol. Chem. 273, 133-142
15. Kaplan, J. (2002) Mechanisms of cellular iron acquisition. Another iron in the fire. Cell (Cambridge, Mass.) 111, 603-606
16. Richardson, D. R. and Ponka, P. (1997) The molecular mechanisms of the metabolism and transport of iron in normal and neoplastic cells. Biochim. Biophys. Acta 1331, 1-40
17. Atkinson, P. G., Blackwell, J. M. and Barton, C. H. (1997) Nramp1 locus encodes a 65 kDa interferon-γ-inducible protein in murine macrophages. Biochem. J. 325, 779-786
18. Canonne-Hergaux, F., Gruenheid, S., Ponka, P. and Gros, P. (1999) Cellular and subcellular localization of the Nramp2 iron transporter in the intestinal brush border and regulation by dietary iron. Blood 93, 4406-4417
19. Garrick, L. M., Dolan, K. G., Romano, M. A. and Garrick, M. D. (1999) Non-transferrin-bound iron uptake in Belgrade and normal rat erythroid cells. J. Cell. Physiol. 178, 349-358
20. Wardrop, S. L. and Richardson, D. R. (1999) The effect of intracellular iron concentration and nitrogen monoxide on Nramp2 expression and non-transferrin-bound iron uptake. Eur. J. Biochem. 263, 41-49
21. Zoller, H., Pietrangelo, A., Vogel, W. and Weiss, G. (1999) Duodenal metal-transporter (DMT-1, NRAMP-2) expression in patients with hereditary haemochromatosis. Lancet 353, 2120-2123
22. McKie, A. T., Latunde-Dada, G. O., Miret, S., McGregor, J. A., Anderson, G. J., Vulpe, C. D., Wrigglesworth, J. M. and Simpson, R. J. (2002) Molecular evidence for the role of a ferric reductase in iron transport. Biochem. Soc. Trans. 30, 722-724
23. Conrad, M. E., Umbreit, J. N., Moore, E. G., Hainsworth, L. N., Porubcin, M., Simovich, M. J., Nakada, M. T., Dolan, K. and Garrick, M. D. (2000) Separate pathways for cellular uptake of ferric and ferrous iron. Am. J. Physiol. Gastrointest. Liver Physiol. 279, G767-G774
24. Ahnert-Hilger, G. and Gratzi, M. (1987) Further characterization of dopamine release by permeabilized PC12 cells. J. Neurochem. 49, 764-770
25. 2+ channels during neuronal differentiation of PC12 cells with nerve growth factor or forskolin. Naunyn Schmiedebergs Arch. Pharmacol. 359, 370-377
26. Mwanjewe, J., Hui, B. K., Coughlin, M. D. and Grover, A. K. (2001) Treatment of PC12 cells with nerve growth factor increases iron uptake. Biochem. J. 357, 881-886
27. Phung, Y. T., Bekker, J. M., Hallmark, O. G. and Black, S. M. (1999) Both neuronal NO synthase and nitric oxide are required for PC12 cell differentiation: a cGMP independent pathway. Brain Res. Mol. Brain Res. 64, 165-178
28. 2+ dependence of non-transferrin-bound iron uptake in PC12 cells. J. Biol. Chem. 275, 33512-33515
29. Epsztejn, S., Kakhlon, O., Glickstein, H., Breuer, W. and Cabantchik, I. (1997) Fluorescence analysis of the labile iron pool of mammalian cells. Anal. Biochem. 248, 31-40
30. Thomas, F., Serratrice, G., Beguin, C., Aman, E. S., Pierre, J. L., Fontecave, M. and Laulhere, J. P. (1999) Calcein as a fluorescent probe for ferric iron. Application to iron nutrition in plant cells. J. Biol. Chem. 274, 13375-13383
31. Gruenheid, S., Canonne-Hergaux, F., Gauthier, S., Hackam, D. J., Grinstein, S. and Gros, P. (1999) The iron transport protein NRAMP2 is an integral membrane glycoprotein that colocalizes with transferrin in recycling endosomes. J. Exp. Med. 189, 831-841
32. 2+ currents in frog pituitary melanotrophs: implication of the inositol triphosphate/protein kinase C pathway. Eur. J. Neurosci. 16, 1907-1916
33. 1-adrenergic agonists in mouse striatal astrocytes. Eur. J. Neurosci. 3, 539-550
34. Marsh, S. J., Trouslard, J., Leaney, J. L. and Brown, D. A. (1995) Synergistic regulation of a neuronal chloride current by intracellular calcium and muscarinic receptor activation: a role for protein kinase C. Neuron 15, 729-737
35. 2+, and γ-aminobutyrate type A channels. Proc. Natl. Acad. Sci. U.S.A. 85, 6192-6196
36. 2+, PKC, or Ras. J. Neurophysiol. 88, 277-288
37. Chen, R., Greene, E. L., Collinsworth, G., Grewal, J. S., Houghton, O., Zeng, H., Garnovskaya, M., Paul, R. V. and Raymond, J. R. (1999) Enrichment of transiently transfected mesangial cells by cell sorting after cotransfection with GFP. Am. J. Physiol. 276, F777-F785
38. Kovala, A. T., Harvey, K. A., McGlynn, P., Boguslawski, G., Garcia, J. G. and English, D. (2000) High-efficiency transient transfection of endothelial cells for functional analysis. FASEB J. 14, 2486-2494
39. 2+-permeable cation channel. Circ. Res. 88, 325-332
40. Goetz, D. H., Holmes, M. A., Borregaard, N., Bluhm, M. E., Raymond, K. N. and Strong, R. K. (2002) The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol. Cell 10, 1033-1043
41. Roth, J. A., Horbinski, C., Higgins, D., Lein, P. and Garrick, M. D. (2002) Mechanisms of manganese-induced rat pheochromocytoma (PC12) cell death and cell differentiation. Neurotoxicology 23, 147-157
42. Yang, J., Goetz, D., Li, J. Y., Wang, W., Mori, K., Setlik, D., Du, T., Erdjument-Bromage, H., Tempst, P., Strong, R. et al. (2002) An iron delivery pathway mediated by a lipocalin. Mol. Cell 10, 1045-1056
43. 125l-ferrotransferrin binding sites in the mesencephalon of control subjects and patients with Parkinson's disease. J. Neurochem. 60, 2338-2341
44. Hirsch, E. C. and Faucheux, B. A. (1998) Iron metabolism and Parkinson's disease. Mov. Disord. 13 (Suppl. 1), 39-45