Biosynthesis of agglomerin A: Stereospecific incorporation of pro-R- and pro-S-hydrogens at sn-C-3 of glycerol into the branched C3 moiety

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 3, 2004, Pages 649-651

  Mashimo, Youichi ^a   Sekiyama, Yasuyo ^a   Araya, Hiroshi ^a   Fujimoto, Yoshinori ^a  

^a TOKYO INSTITUTE OF TECHNOLOGY   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

1,3 BISPHOSPHOGLYCERIC ACID; AGGLOMERIN A; GLYCERIC ACID; GLYCEROL DERIVATIVE; HYDROGEN; UNCLASSIFIED DRUG;

ARTICLE; DRUG SYNTHESIS; FEEDING; PANTOEA AGGLOMERANS; PRECURSOR; PROTON NUCLEAR MAGNETIC RESONANCE; STEREOSPECIFICITY;

ENTEROBACTER; PANTOEA AGGLOMERANS;

EID: 1642534343     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.056     Document Type: Article

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11. 3, pH 7.2 adjusted by the addition of dil. HCl, were autoclaved. This was innoculated with E. agglomerans PB-6042 and the cultures were incubated at 25 °C in the light for 72 h on a rotary shaker at 200 rpm. The fermentation broth was processed as described in ref 6 to give 1 (7 mg) after reversed-phase HPLC purification.
12. 2H]glycerol metabolite.