Alteration of met protooncogene product expression and prognosis in breast carcinomas

Analytical and Quantitative Cytology and Histology

Volumn 21, Issue 5, 1999, Pages 397-408

  Tsarfaty, Ilan ^a   Alvord, W Gregory ^b   Resau, James H ^b   Altstock, Rom T ^a   Lidereau, Rosette ^c   Bieche, Ivan ^c   Bertrand, Françoise ^c   Horev, Judith ^a   Klabansky, Richard L ^b   Keydar, Iafa ^a   Vande Woude, George F ^d,e  

^a TEL AVIV UNIVERSITY   (Israel)

^b Data Management Services Inc   (United States)

^c CENTRE RENÉ HUGUENIN   (France)

^d NATIONAL CANCER INSTITUTE   (United States)

^e NATIONAL CANCER INSTITUTE   (United States)

Author keywords

Breast cancer; Confocal microscopy; Image analysis; Met; Node negative

Indexed keywords

ESTROGEN RECEPTOR; PROGESTERONE RECEPTOR; SCATTER FACTOR RECEPTOR;

ADULT; AGED; ARTICLE; BREAST CARCINOMA; CANCER SURVIVAL; CONTROLLED STUDY; GENE EXPRESSION; HETEROZYGOSITY; HUMAN; IMAGE ANALYSIS; IMMUNOHISTOCHEMISTRY; MAJOR CLINICAL STUDY; MASTECTOMY; MUTATION; PRIORITY JOURNAL; PROGNOSIS;

ADENOCARCINOMA; BLOTTING, WESTERN; BREAST; BREAST NEOPLASMS; DISEASE-FREE SURVIVAL; FEMALE; FLUORESCENT ANTIBODY TECHNIQUE, INDIRECT; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; LYMPHATIC METASTASIS; MICROSCOPY, CONFOCAL; PROGNOSIS; PROTO-ONCOGENE PROTEINS C-MET; SURVIVAL RATE;

EID: 1642530314     PISSN: 08846812     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (49)

1. Parker SL, Tong T, Bolden S, Wingo PA: Cancer statistics. CA Cancer J Clin 1997;47:5-27
2. McGuire WL, Tandon AK, Allred DC, Chamness GC, Ravdin PM, Clark GM: Prognosis and treatment decisions in patients with breast cancer without axillary node involvement. Cancer 1992;70:1775-1781
3. Park M, Dean M, Kaul K, Braun MJ, Gonda MA, Vande Woude GF: Sequence of MET protooncogene cDNA has features characteristic of the tyrosine kinase family of growth-factor receptors. Proc Natl Acad Sci USA 1987;84:6379-6383
4. Gonzatti-Haces M, Seth A, Park M, Copeland T, Oroszlan S, Vande Woude GF: Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc Natl Acad Sci USA, 1988;85:21-25
5. Bottaro DP, Rubin JS, Faletto DL, Chan AM, Kmiecik TE, Vande Woude GF, Aaronson SA: Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science 1991;251:802-804
6. Naldini L, Vigna E, Narsimhan RP, Gaudino G, Zarnegar R, Michalopoulos GK, Comoglio PM: Hepatocyte growth factor (HGF) stimulates the tyrosine kinase activity of the receptor encoded by the proto-oncogene c-MET. Oncogene 1991;6:501-504
7. Igawa T, Kanda S, Kanetake H, Saitoh Y, Ichihara A, Tomita Y, Nakamura T: Hepatocyte growth factor is a potent mitogen for cultured rabbit renal tubular epithelial cells. Biochem Biophys Res Commun 1991;174:831-838
8. Rubin JS, Chan AM, Bottaro DP, Burgess WH, Taylor WG, Cech AC, Hirschfield DW, Wong J, Miki T, Finch PW, Aaronson SA: A broad-spectrum human lung fibroblast-derived mitogen is a variant of hepatocyte growth factor. Proc Natl Acad Sci USA 1991;88:415-419
9. Jeffers M, Rong S, Vande Woude GF: Hepatocyte growth factor/scatter factor-Met signaling in tumorigenicity and invasion/metastasis. J Mol Med 1996;74:505-513
10. Cooper CS, Blair DG, Oskarsson MK, Tainsky MA, Eader LA, Vande Woude GF: Characterization of human transforming genes from chemically transformed, teratocarcinoma, and pancreatic carcinoma cell lines. Cancer Res 1984;44:1-10
11. Cooper CS, Park M, Blair DG, Tainsky MA, Huebner K, Croce CM, Vande Woude GF: Molecular cloning of a new transforming gene from a chemically transformed human cell line. Nature 1984;311:29-33
12. Iyer A, Kmiecik TE, Park M, Daar I, Blair D, Dunn KJ, Sutrave P, Ihle JN, Bodescot M, Vande Woude GF: Structure, tissue-specific expression, and transforming activity of the mouse met protooncogene. Cell Growth Differ 1990;1:87-95
13. Rong S, Bodescot M, Blair D, Dunn J, Nakamura T, Mizuno K, Park M, Chan A, Aaronson S, Vande Woude GF: Tumorigenicity of the met proto-oncogene and the gene for hepatocyte growth factor. Mol Cell Biol 1992;12:5152-5158
14. Rong S, Donehower LA, Hansen MF, Strong L, Tainsky M, Jeffers M, Resau JH, Hudson E, Tsarfaty I, Vande Woude GF: Met proto-oncogene product is overexpressed in tumors of p53-deficient mice and tumors of Li-Fraumeni patients. Cancer Res 1995;55:1963-1970
15. Rahimi N, Tremblay E, McAdam L, Park M, Schwall R, Elliott B: Identification of a hepatocyte growth factor autocrine loop in a murine mammary carcinoma. Cell Growth Differ 1996;7:263-270
16. Jeffers M, Rong S, Anver M, Vande Woude G F: Autocrine hepatocyte growth factor/scatter factor-Met signaling induces transformation and invasive/metastatic phenotype in C127 cells. Oncogene 1996;13:853-861
17. Koochekpour S, Jeffers M, Rulong S, Taylor G, Klineberg E, Hudson E, Resau J, Vande Woude G: Met and hepatocyte growth factor/scatter factor expression in human gliomas. Cancer Res 1997;57:5391-5398
18. Montesano R, Matsumoto K, Nakamura T, Orci L: Identification of a fibroblast-derived epithelial morphogen as hepatocyte growth factor. Cell 1991;67:901-908
19. Tsarfaty I, Resau JH, Rulong S, Keydar I, Faletto DL, Vande Woude G: The met proto-oncogene receptor and lumen formation. Science 1992;257:1258-1261
20. Tsarfaty I, Rong S, Resau JH, Rulong S, Pinto da Silva P, Vande Woude GF: The Met proto-oncogene in mesenchymal to epithelial cell conversion. Science 1994;263:98-101
21. Berdichevsky F, Alford D, D'Souza B, Taylor-Papadimitriou J: Branching morphogenesis of human mammary epithelial cells in collagen gels. J Cell Sci 1994;107:3557-3568
22. Soriano JV, Pepper MS, Nakamura T, Orci L, Montesano R: Hepatocyte growth factor stimulates extensive development of branching duct-like structures by cloned mammary gland epithelial cells. J Cell Sci 1995;108:413-430
23. Yang Y, Spitzer E, Meyer D, Sachs M, Niemann C, Hartmann G, Weidner KM, Birchmeier C, Birchmeier W: Sequential requirement of hepatocyte growth factor and neuregulin in the morphogenesis and differentiation of the mammary gland. J Cell Biol 1995;131:215-226
24. Pepper MS, Soriano JV, Menoud PA, Sappino AP, Orci L, Montesano R: Modulation of hepatocyte growth factor and c-met in the rat mammary gland during pregnancy, lactation, and involution. Exp Cell Res 1995;219:204-210
25. Niranjan B, Buluwela L, Yant J, Perusinghe N, Atherton A, Phippard D, Dale T, Gusterson B, Kamalati T: HGF/SF: A potent cytokine for mammary growth, morphogenesis and development. Development 1995;121:2897-2908
26. Yamashita J, Ogawa M, Yamashita S, Nomura K, Kuramoto M, Saishoji T, Shin S: Immunoreactive hepatocyte growth factor is a strong and independent predictor of recurrence and survival in human breast cancer. Cancer Res 1994;54: 1630-1633
27. Bieche I, Champ'eme MH, Matifas F, Hac'ene K, Callahan R, Lidereau R: Loss of heterozygosity on chromosome 7q and aggressive primary breast cancer. Lancet 1992;339:139-143
28. Nagy J, Clark JS, Cooke A, Campbell AM, Connor JM, Purushotham AD, George WD: Expression and loss of heterozygosity of c-met proto-oncogene in primary breast cancer. J Surg Oncol 1995;60:95-99
29. Jin L, Pang YY, Joseph A, Li Y, Rosen EM, Bhargava MM, Goldberg ID: Rat placental hepatocyte growth factor/scatter factor: Purification, characterization, and developmental regulation. Proc Soc Exp Biol Med 1993;204:75-80
30. Yamashita J, Ogawa M, Beppu T: Immunoreactive hepatocyte growth factor is present in tissue extracts from human breast cancer but not in conditioned medium of human breast cancer cell lines. Res Commun Chem Pathol Pharmacol 1993;82:249-252
31. Faletto DL, Tsarfaty I, Kmiecik TE, Gonzatti M, Suzuki T, Vande Woude GF: Evidence for non-covalent clusters of the c-met proto-oncogene product. Oncogene 1992;7:1149-1157
32. Shapiro HM: Practical Flow Cytometry. Third edition. New York, Alan R Liss, 1995
33. Young IT: Proof without prejudice: Use of the Kolmogorov-Smirnov test for the analysis of histograms from flow systems and other sources. J Histochem Cytochem 1977;25: 935-941
34. Overton WR: Modified histogram subtraction technique for analysis of flow cytometry data. Cytometry 1988;9:619-626 (see also Erratum, Cytometry 1989;10:492-494)
35. Klineberg E, Tsarfaty I, Alvord G, Sathyanarayana B, Resau J: Correction and quantification of normal differentiation in human epithelium: Application for Optimas 4.0 image analysis program. Cell Vision 1996;5:402-406
36. Kaplan EL, Meier P: Nonparametric estimation from incomplete observations. J Am Stat Soc 1958;53:457-481
37. Cox DR: Regression models and life-tables. J R Stat Soc 1972; 34:187-220
38. Kalbfleisch JD, Prentice RL: The Statistical Analysis of Failure Time Data. New York, John Wiley, 1980
39. Collett D: Modelling Survival Data in Medical Research. London, Chapman & Hall, 1994
40. Tandon AK, Clark GM, Chamness GC, Chirgwin JM, McGuire WL: Cathepsin D and prognosis in breast cancer. N Engl J Med 1990;322:297-302
41. Wang Y, Selden AC, Morgan N, Stamp GW, Hodgson HJ: Hepatocyte growth factor/scatter factor expression in human mammary epithelium. Am J Pathol 1994;144:675-682
42. Tuck AB, Park M, Sterns EE, Boag A, Elliott BE: Coexpression of hepatocyte growth factor and receptor (Met) in human breast carcinoma. Am J Pathol 1996;148:225-232
43. Rong S, Segal S, Anver M, Resau JH, Vande Woude GF: Invasiveness and metastasis of NIH/3T3 cells induced by Met-HGF/SF autocrine stimulation. Proc Natl Acad Sci USA 1994;91:4731-4735
44. Belfiore A, Gangemi P, Costantino A, Russo G, Santonocito GM, Ippolito O, Di Renzo MF, Comoglio P, Fiumara A, Vigneri R: Negative/low expression of the Met/hepatocyte growth factor receptor identifies papillary thyroid carcinomas with high risk of distant metastases. J Clin Endocrinol Metab 1997;82:2322-2328
45. Vande Woude GF, Jeffers M, Cortner J, Alvord G, Tsarfaty I, Resau J: Met-HGF/SF: Tumorigenesis, invasion, and metastasis. In CIBA Foundation Symposium 212: Plasminogen-Related Growth Factors. Edited by GRB Goode. West Sussex, England, John Wiley & Sons, 1997, pp 119-132
46. Peifer M: Beta-catenin as oncogene: The smoking gun. Science 1997;275:1752-1753
47. Shima N, Nagao M, Ogaki F, Tsuda E, Murakami A, Higashio K: Tumor cytotoxic factor/hepatocyte growth factor from human fibroblasts: Cloning of its cDNA, purification and characterization of recombinant protein. Biochem Biophys Res Commun 1991;180:1151-1158
48. Shima N, Itagaki Y, Nagao M, Yasuda H, Morinaga T, Higashio K: A fibroblast-derived tumor cytotoxic factor/F-TCF (hepatocyte growth factor/HGF) has multiple functions in vitro. Cell Biol Int Rep 1991;15:397-408
49. Jeffers M, Rong S, Vande Woude GF: Enhanced tumorigenicity and invasion-metastasis by hepatocyte growth factor/scatter factor-Met signalling in human cells concomitant with induction of the urokinase proteolysis network. Mol Cell Biol 1996;16:1115-1125