Evaluation of the bioavailability and pharmacokinetics of two extended-release theophylline formulations in dogs

Journal of the American Veterinary Medical Association

Volumn 224, Issue 7, 2004, Pages 1113-1119

  Bach, Jonathan F ^a,c   Kukanich, Butch ^b   Papich, Mark G ^b   McKiernan, Brendan C ^a  

^a North Carolina State University ^*  (United States)

^b NORTH CAROLINA STATE UNIVERSITY   (United States)

^c TUFTS UNIVERSITY   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

THEOPHYLLINE;

ANIMAL EXPERIMENT; ARTICLE; BLOOD LEVEL; COMPARTMENT MODEL; CONTROLLED STUDY; DOG; DRUG ABSORPTION; DRUG BIOAVAILABILITY; DRUG ELIMINATION; DRUG FORMULATION; DRUG HALF LIFE; FEMALE; FLUORESCENCE POLARIZATION IMMUNOASSAY; MALE; NONHUMAN; RANDOMIZATION; SUSTAINED RELEASE PREPARATION;

ADMINISTRATION, ORAL; ANIMALS; BIOLOGICAL AVAILABILITY; BRONCHODILATOR AGENTS; CAPSULES; COMPUTER SIMULATION; CROSS-OVER STUDIES; DELAYED-ACTION PREPARATIONS; DOGS; DRUG ADMINISTRATION SCHEDULE; FEMALE; HALF-LIFE; INJECTIONS, INTRAVENOUS; MALE; RANDOM ALLOCATION; TABLETS; THEOPHYLLINE;

ANIMALIA; CANIS FAMILIARIS;

EID: 1642523515     PISSN: 00031488     EISSN: None     Source Type: Journal    
DOI: 10.2460/javma.2004.224.1113     Document Type: Article

References (25)

1. Ettinger, SJ. Textbook of veterinary internal medicine. 5th ed. Philadelphia: WB Saunders Co, 2000;1055-1057.
2. Bonagura JD, CVT update: canine chronic bronchitis. In: Kirk's current veterinary therapy XIII. Philadelphia: WB Saunders Co, 2000;801-805.
3. McKiernan BC. Diagnosis and treatment of canine chronic bronchitis. Twenty years of experience. Vet Clin North Am Small Anim Pract 2000;6:1267-1278.
4. Koritz GD, McKiernan BC, Neff-Davis CA, et al. Bioavailability of four slow-release theophylline formulations in the Beagle dog. J Vet Pharmacol Ther 1986;9:293-302.
5. Dye JA, McKiernan BC, Jones SD, et al. Sustained-release theophylline pharmacokinetics in the cat. J Vet Pharmacol Ther 1989;12:133-140.
6. Dye JA, McKiernan BC, Neff-Davis CA, et al. Chronopharmacokinetics of theophylline in the cat. J Vet Pharmacol Ther 1990;13:278-286.
7. Yamoaoka K, Nakagawa T, Uno T. Application of Akaike's Information Criterion (AIC) in the evaluation of linear pharmacokinetic equations. J Pharmacol Biopharm 1978;6:165-175.
8. Weinberger M. The pharmacology and therapeutic use of theophylline. J Allergy Clin Immunol 1984;73:525-540.
9. Hamlin RL, Sally JL. Lack of arrhythmogenicity of aminophylline in dogs. J Vet Pharmacol Ther 1993;16:15-22.
10. Weinberger M, Hendeles L. Theophylline in asthma. N Engl J Med 1996;334:1380-1388.
11. Holford N, Black P, Couch R, et al. Theophylline target concentration in severe airways obstruction - 10 or 20 mg/L? A randomized concentration-controlled trial. Clin Pharmacokinet 1993;25:495-505.
12. Munsiff U, McKiernan BC, Neff-Davis CA, et al. Determination of the acute oral toxicity of theophylline in conscious dogs. J Vet Pharmacol Ther 1988;11:381-389.
13. Dressman JB. Comparison of canine and human gastrointestinal physiology Pharmacol Res 1986;3:123-131.
14. Kararli TT. Comparison of the gastrointestinal anatomy, physiology, and biochemistry of humans and commonly used laboratory animals. Biopharm Drug Dispos 1995;16:351-380.
15. Frey HH, Göbel W, Löscher W. Pharmacokinetics of primidone and its active metabolites in the dog. Arch Int Pharmacodyn Ther 1979;242:14-30.
16. Rozanski EA. Allergic lung disease in cats and dogs. Vet Med 2001;308-320.
17. Undem BJ, Lichtenstein LM. Drugs used in the treatment of asthma. In: Hardman JG, Limbird LE, eds Goodman and Gilman's the pharmacological basis of therapeutics. 10th ed. New York: McGraw-Hill Book Co, 2001;733-754.
18. Murciano D, Aubier M, Lecocguie Y, et al. Effects of theophylline on diaphragmatic strength and fatigue in patients with chronic obstructive pulmonary disease. N Engl J Med 1984;311:349-353.
19. Nassar CF, Saadeh FM, Ayyash RE, et al. Effects of aminophylline and terbutaline sulfate on the contractility of feline diaphragm. Gen Pharmacol 1991;22:1191-1197.
20. Janssens S, Derom E, Reid MB, et al. Effects of theophylline on canine diaphragmatic contractility and fatigue. Am Rev Respir Dis 1991;144:1250-1255.
21. Howell S, Roussos C. Isoproterenol and aminophylline improve contractility of fatigued canine diaphragm. Am Rev Respir Dis 1984;129:118-124.
22. Aubier M, Murciano D, Viires N, et al. Diaphragmatic contractility enhanced by aminophylline: role of extracellular calcium. J Appl Physiol 1983;54:460-464.
23. Warner A. Effects of methylxanthines on mucociliary function. Am J Med 1985;79:16-21.
24. Ziment I. Theophylline and mucociliary clearance. Chest 1987;92(suppl 1):38S-43S.
25. Dunn ME, Taylor SM, Shmon CL, et al. Effects of theophylline on tracheal mucociliary clearance rates in healthy cats. Am J Vet Res 2002;63:1320-1322.