Decreased frequencies of virus-specific T helper type 1 cells during interferon alpha plus ribavirin treatment in HIV-hepatitis C virus co-infection

AIDS

Volumn 18, Issue 1, 2004, Pages 121-123

  Alatrakchi, Nadia ^a   Martino, Vincent Di ^a   Thibault, Vincent ^a   Benhamou, Yves ^a   Katlama, Christine ^a   Poynard, Thierry ^a   Autran, Brigitte ^a  

^a PITIÉ SALPÊTRIÈRE HOSPITAL   (France)

Author keywords

[No Author keywords available]

Indexed keywords

ALPHA INTERFERON; RIBAVIRIN;

ARTICLE; COMORBIDITY; CYTOMEGALOVIRUS; DISEASE ASSOCIATION; DRUG EFFICACY; FOLLOW UP; HEPATITIS C; HEPATITIS C VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS; HUMAN IMMUNODEFICIENCY VIRUS INFECTION; IMMUNE RESPONSE; IMMUNOREACTIVITY; IMMUNOSUPPRESSIVE TREATMENT; PRIORITY JOURNAL; T LYMPHOCYTE SUBPOPULATION; TH1 CELL;

ANTIVIRAL AGENTS; CD4 LYMPHOCYTE COUNT; CYTOMEGALOVIRUS INFECTIONS; ENZYME-LINKED IMMUNOSORBENT ASSAY; HEPATITIS C, CHRONIC; HIV INFECTIONS; HUMANS; IMMUNITY, CELLULAR; INTERFERON-ALPHA; LYMPHOCYTE ACTIVATION; RIBAVIRIN; TH1 CELLS;

EID: 1642506090     PISSN: 02699370     EISSN: None     Source Type: Journal    
DOI: 10.1097/00002030-200401020-00016     Document Type: Article

References (6)

1. Tilg H. New insights into the mechanisms of interferon alpha: an immunoregulatory and anti-inflammatory cytokine. Gastroenterology 1997, 112:1017-1021.
2. Meier V, Bürger E, Mihm S, Sale B, Ramadori C. Ribavirin inhibits DNA, RNA, and protein synthesis in PHA-stimulated human peripheral blood mononuclear cells: possible explanation for therapeutic efficacy in patients with chronic HCV infection. J Med Virol 2003, 69:50-58.
3. Alatrakchi N, Di Martino V, Thibault V, Autran B, and the ALT and IMMUNE-VIRC ANRS Study Groups. Strong CD4 Th1 responses to HIV and hepatitis C virus in HIV-infected long-term non-progressors co-infected with hepatitis C virus. AIDS 2002, 16:713-717.
4. Cramp ME, Rossol S, Chokshi S, Carucci P, Williams R, Naoumov NV. Hepatitis C virus-specific T-cell reactivity during interferon and ribavirin treatment in chronic hepatitis C. Gastroenterology 2000, 118:346-355.
5. Legrand E, Neau D, Galperine T, Trimoulet P, Moreau JF, Pitard V, et al. CD4 T lymphocyte proliferate responses to hepatitis C virus (HCV) antigens in patients coinfected with HCV and human immunodeficiency virus who responded to anti-HCV treatment. J Infect Dis 2002, 186:302-311.
6. Pitcher CJ, Quittner C, Peterson DM, Connors M, Koup RA, Maino VC, Picker LJ. HIV-1-specific CD4+ T cells are detectable in most individuals with active HIV-1 infection, but decline with prolonged viral suppression. Nat Med 1999, 5:483-484.