First-Choice Antibiotics at Subinhibitory Concentrations Induce Persistence of Chlamydia pneumoniae

Antimicrobial Agents and Chemotherapy

Volumn 48, Issue 4, 2004, Pages 1402-1405

  Gieffers, Jens ^a   Rupp, Jan ^a   Gebert, Andreas ^a   Solbach, Werner ^a   Klinger, Matthias ^a  

^a UNIVERSITY OF LÜBECK   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ANTIBIOTIC AGENT; CIPROFLOXACIN; DOXYCYCLINE; ERYTHROMYCIN; MACROLIDE; QUINOLINE DERIVED ANTIINFECTIVE AGENT; RIFAMPICIN; TETRACYCLINE;

ARTICLE; BACTERIAL GROWTH; CHLAMYDOPHILA PNEUMONIAE; CONTROLLED STUDY; DRUG CHOICE; GENE EXPRESSION; HELA CELL; HUMAN; HUMAN CELL; INFECTION; MORPHOLOGY; NONHUMAN; PRIORITY JOURNAL; PROGENY;

ANTI-BACTERIAL AGENTS; CHLAMYDIA INFECTIONS; CHLAMYDOPHILA PNEUMONIAE; FLUORESCENT ANTIBODY TECHNIQUE; HELA CELLS; HUMANS; MICROSCOPY, ELECTRON;

EID: 1642502276     PISSN: 00664804     EISSN: None     Source Type: Journal    
DOI: 10.1128/AAC.48.4.1402-1405.2004     Document Type: Article

References (6)

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2. Beatty, W. L., G. I. Byrne, and R. P. Morrison. 1993. Morphologic and antigenic characterization of interferon gamma-mediated persistent Chlamydia trachomatis infection in vitro. Proc. Natl. Acad. Sci. USA 90:3998-4002.
3. Gieffers, J., R. J. Belland, W. Whitmire, S. Ouellette, D. Crane, M. Maass, G. I. Byrne, and H. D. Caldwell. 2002. Isolation of Chlamydia pneumoniae clonal variants by a focus-forming assay. Infect. Immun. 70:5827-5834.
4. Gieffers, J., H. Fullgraf, J. Jahn, M. Klinger, K. Dalhoff, H. A. Katus, W. Solbach, and M. Maass. 2001. Chlamydia pneumoniae infection in circulating human monocytes is refractory to antibiotic treatment. Circulation 103:351-356.
5. Hammerschlag, M. R., K. Chirgwin, and P. M. Roblin. 1992. Persistent infection with Chlamydia pneumoniae following acute respiratory illness. Clin. Infect. Dis. 14:178-182.
6. Kutlin, A., P. M. Roblin, and M. R. Hammerschlag. 1999. In vitro activities of azithromycin and ofloxacin against Chlamydia pneumoniae in a continuous-infection model. Antimicrob. Agents Chemother. 43:2268-2272.