Presentation of a Self-peptide in Two Distinct Conformations by a Disease-associated HLA-B27 Subtype

Journal of Experimental Medicine

Volumn 199, Issue 2, 2004, Pages 151-154

  Wucherpfennig, Kai W ^a,b  

^a HARVARD MEDICAL SCHOOL   (United States)

^b DANA FARBER CANCER INSTITUTE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

HLA B27 ANTIGEN; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 1; MAJOR HISTOCOMPATIBILITY ANTIGEN CLASS 2;

ANKYLOSING SPONDYLITIS; CHROMOSOME 6; COMPLEX FORMATION; CRYSTAL STRUCTURE; DISEASE ASSOCIATION; GENETIC POLYMORPHISM; GENETIC SUSCEPTIBILITY; HUMAN; MAJOR HISTOCOMPATIBILITY COMPLEX; NOTE; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN CONFORMATION; SEQUENCE ANALYSIS;

ANTIGEN PRESENTATION; AUTOANTIGENS; BINDING SITES; HLA-B27 ANTIGEN; HUMANS; MODELS, MOLECULAR; POLYMORPHISM, GENETIC; PROTEIN BINDING; PROTEIN CONFORMATION; RECEPTORS, ANTIGEN, T-CELL; SPONDYLITIS, ANKYLOSING;

EID: 1642500090     PISSN: 00221007     EISSN: None     Source Type: Journal    
DOI: 10.1084/jem.20032050     Document Type: Note

References (17)

1. Hülsmeyer, M., M.T. Fiorillo, F. Bettosini, R. Sorrentino, W. Saenger, A. Ziegler, and B. Uchanska-Ziegler. 2004. Dual, HLA-B27 subtype-dependent conformation of a self-peptide. J. Exp. Med. 199:271-281.
2. Brewerton, D.A., F.D. Hart, A. Nicholls, M. Caffrey, D.C. James, and R.D. Sturrock. 1973. Ankylosing spondylitis and HL-A 27. Lancet. 1:904-907.
3. Schlosstein, L., P.I. Terasaki, R. Bluestone, and C.M. Pearson. 1973. High association of an HL-A antigen, W27, with ankylosing spondylitis. N. Engl. J. Med. 288:704-706.
4. Feltkamp, T.E., A. Mardjuadi, F. Huang, and C.T. Chou. 2001. Spondyloarthropathies in eastern Asia. Curr. Opin. Rheumatol. 13:285-290.
5. D'Amato, M., M.T. Fiorillo, C. Carcassi, A. Mathieu, A. Zuccarelli, P.P. Bitti, R. Tosi, and R. Sorrentino. 1995. Relevance of residue 116 of HLA-B27 in determining susceptibility to ankylosing spondylitis. Eur. J. Immunol. 25:3199-3201.
6. Madden, D.R., J.C. Gorga, J.L. Strominger, and D.C. Wiley. 1991. The structure of HLA-B27 reveals nonamer self-peptides bound in an extended conformation. Nature. 353:321-325.
7. Jardetzky, T.S., W.S. Lane, R.A. Robinson, D.R. Madden, and D.C. Wiley. 1991. Identification of self peptides bound to purified HLA-B27. Nature. 353:326-329.
8. Madden, D.R., D.N. Garboczi, and D.C. Wiley. 1993. The antigenic identity of peptide-MHC complexes: a comparison of the conformations of five viral peptides presented by HLA-A2. Cell. 75:693-708.
9. Fremont, D.H., M. Matsumura, E.A. Stura, P.A. Peterson, and I.A. Wilson. 1992. Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb. Science. 257:919-927.
10. Speir, J.A., J. Stevens, E. Joly, G.W. Butcher, and I.A. Wilson. 2001. Two different, highly exposed, bulged structures for an unusually long peptide bound to rat MHC class I RT1-Aa. Immunity. 14:81-92.
11. Stern, L.J., J.H. Brown, T.S. Jardetzky, J.C. Gorga, R.G. Urban, J.L. Strominger, and D.C. Wiley. 1994. Crystal structure of the human class II MHC protein HLA-DR1 complexed with an influenza virus peptide. Nature. 368:215-221.
12. Fiorillo, M.T., M. Maragno, R. Butler, M.L. Dupuis, and R. Sorrentino. 2000. CD8(+) T-cell autoreactivity to an HLA-B27-restricted self-epitope correlates with ankylosing spondylitis. J. Clin. Invest. 106:47-53.
13. Ramos, M., A. Paradela, M. Vazquez, A. Marina, J. Vazquez, and J.A. Lopez de Castro. 2002. Differential association of HLA-B*2705 and B*2709 to ankylosing spondylitis correlates with limited peptide subsets but not with altered cell surface stability. J. Biol. Chem. 277:28749-28756.
14. Sieper, J. 2001. Pathogenesis of reactive arthritis. Curr. Rheumatol. Rep. 3:412-418.
15. Hermann, E., D.T. Yu, K.H. Meyer zum Buschenfelde, and B. Fleischer. 1993. HLA-B27-restricted CD8 T cells derived from synovial fluids of patients with reactive arthritis and ankylosing spondylitis. Lancet. 342:646-650.
16. Todd, J.A., J.I. Bell, and H.O. McDevitt. 1987. HLA-DQ beta gene contributes to susceptibility and resistance to insulin-dependent diabetes mellitus. Nature. 329:599-604.
17. Lee, K.H., K.W. Wucherpfennig, and D.C. Wiley. 2001. Structure of a human insulin peptide-HLA-DQ8 complex and susceptibility to type 1 diabetes. Nat. Immunol. 2:501-507.