N-acetylation of the glutamate residue of intact glutathione conjugates in rats: A novel pathway for the metabolic processing of thiol adducts of xenobiotics

Drug Metabolism and Disposition

Volumn 32, Issue 1, 2004, Pages 43-48

  Yin, Wenji ^a   Doss, George A ^a   Stearns, Ralph A ^a   Kumar, Sanjeev ^a  

^a MERCK RESEARCH LABORATORIES   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

ACETYL COENZYME A; GLUTAMIC ACID; GLUTATHIONE; GLUTATHIONE DERIVATIVE; N ACETYLPYROGLUTAMATE; PYROGLUTAMIC ACID; THIOL DERIVATIVE; UNCLASSIFIED DRUG; XENOBIOTIC AGENT;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; BILE; CATALYSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DISSOCIATION; DRUG ACETYLATION; DRUG METABOLISM; GLUTATHIONE METABOLISM; INCUBATION TIME; ION TRAP MASS SPECTROMETRY; LIQUID CHROMATOGRAPHY; LIVER CELL; LIVER MICROSOME; MALE; MASS SPECTROMETRY; METABOLIC REGULATION; NONHUMAN; ONLINE ANALYSIS; PRIORITY JOURNAL; PROCESS CONTROL; RAT; RESIDUE ANALYSIS;

ACETYLATION; ANIMALS; BILE; CHROMATOGRAPHY, LIQUID; GLUTAMIC ACID; GLUTATHIONE; HEPATOCYTES; MALE; MASS SPECTROMETRY; MOLECULAR WEIGHT; RATS; RATS, SPRAGUE-DAWLEY; SULFHYDRYL COMPOUNDS; XENOBIOTICS;

ANIMALIA;

EID: 1642498325     PISSN: 00909556     EISSN: None     Source Type: Journal    
DOI: 10.1124/dmd.32.1.43     Document Type: Article

References (12)

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