Stability and compatibility of reconstituted ertapenem with commonly used i.v. infusion and coinfusion solutions

American Journal of Health-System Pharmacy

Volumn 61, Issue 1, 2004, Pages 38-45

  McQuade, Michael S ^a,c   Van Nostrand, Vincent ^a   Schariter, Joseph ^a   Kanike, Jennifer Domsicz ^b   Forsyth, Richard J ^c  

^a Pharmaceutical Analysis and Control   (United States)

^b Regulatory and Analytical Sciences   (United States)

^c MERCK RESEARCH LABORATORIES   (United States)

Author keywords

Antibiotics; Anticoagulants; Concentration; Containers; Dextrose; Diluents; Electrolytes; Ertapenem sodium; Excipients; Glass; Heparin sodium; Hetastarch; Incompatibilities; Injections; Mannitol; Polyvinyl chloride; Potassium chloride; Replacement solutions

Indexed keywords

ANTIBIOTIC AGENT; ANTICOAGULANT AGENT; ERTAPENEM; GLUCOSE; HEPARIN; HETASTARCH; MANNITOL; POLYVINYLCHLORIDE; POTASSIUM CHLORIDE; RINGER LACTATE SOLUTION; BETA LACTAM; LACTAM;

ANTIBIOTIC THERAPY; ARTICLE; CONCENTRATION RESPONSE; CONTINUOUS INFUSION; DRUG FORMULATION; DRUG STABILITY; DRUG STORAGE; EXCIPIENT COMPATIBILITY; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; INFUSION; PRIORITY JOURNAL; ROOM TEMPERATURE; TEMPERATURE MEASUREMENT; CHEMISTRY; DRUG INTERACTION; HEALTH SERVICES RESEARCH; INTRAVENOUS DRUG ADMINISTRATION; UNITED STATES;

BETA-LACTAMS; CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG INTERACTIONS; DRUG STABILITY; HEALTH SERVICES RESEARCH; INFUSIONS, INTRAVENOUS; LACTAMS; UNITED STATES;

EID: 1642487219     PISSN: 10792082     EISSN: None     Source Type: Journal    
DOI: 10.1093/ajhp/61.1.38     Document Type: Article

References (7)

1. Invanz (ertapenem sodium for injection) package insert. Whitehouse Station, NJ: Merck & Co., Inc.; 2001 Nov.
2. Primaxin i.v. (imipenem-cilastatin sodium for injection) package insert. West Point, PA: Merck & Co., Inc.; 1999 Feb.
3. Merrem i.v. (meropenem for injection) package insert. Wilmington, DE: Astra-Zeneca Pharmaceuticals LP; 2001 Feb.
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6. Walker SE, Varrin S, Yannicelli D et al. Stability of meropenem in saline and dextrose solutions and compatibility with potassium chloride. Can J Hosp Pharm. 1998; 51:156-68.
7. Sajonz P, Natishan TK, Wu Y et al. Preparation, isolation, and characterization of dimeric degradation products of the 1β-methylcarbapenem antibiotic, ertapenem. J Liq Chromatogr. 2001; 24:2999-3015.