Significance of hormone receptor status and tumor vessels in normal, hyperplastic and neoplastic endometrium

Pathology International

Volumn 53, Issue 12, 2003, Pages 846-852

  Nunobiki, Osamu ^a   Taniguchi, Emiko ^a   Ishii, Aiko ^a   Tang, Weihua ^a   Utsunomiya, Hitoshi ^a   Nakamura, Yasushi ^a   Mori, Ichiro ^a   Kakudo, Kennichi ^a  

^a WAKAYAMA MEDICAL UNIVERSITY   (Japan)

Author keywords

Adenocarcinoma; Endometrial hyperplasia; Estrogen receptor alpha; Microvessel density; Progesterone receptor

Indexed keywords

CYCLIN D1; ESTROGEN RECEPTOR ALPHA; KI 67 ANTIGEN; PEROXIDASE; PROGESTERONE RECEPTOR;

ADULT; ARTICLE; CONTROLLED STUDY; DISEASE COURSE; ENDOMETRIUM; ENDOMETRIUM HYPERPLASIA; ENDOMETRIUM TUMOR; FEMALE; HUMAN; HUMAN CELL; HUMAN TISSUE; MAJOR CLINICAL STUDY; MICROVASCULATURE; PRIORITY JOURNAL; PROGNOSIS; PROTEIN EXPRESSION; VENULE;

ADENOCARCINOMA; ADULT; CYCLIN D1; ENDOMETRIAL HYPERPLASIA; ENDOMETRIAL NEOPLASMS; ENDOMETRIUM; FEMALE; HUMANS; IMAGE PROCESSING, COMPUTER-ASSISTED; KI-67 ANTIGEN; MICROCIRCULATION; MIDDLE AGED; NEOVASCULARIZATION, PATHOLOGIC; NEOVASCULARIZATION, PHYSIOLOGIC; RECEPTORS, ESTROGEN; RECEPTORS, PROGESTERONE; TUMOR MARKERS, BIOLOGICAL;

EID: 1642481067     PISSN: 13205463     EISSN: None     Source Type: Journal    
DOI: 10.1046/j.1440-1827.2003.01565.x     Document Type: Article

References (24)

1. Chambers JT, Carcangiu ML, Voynick IM, Schwartz PE. Immunohistochemical evaluation of estrogen and progesterone receptor content in 183 patients with endometrial carcinoma. Am J Clin Pathol 1990; 94: 255-60.
2. Sivridis E, Giatromanolaki A, Gatter KC, Harris AL, Koukourakis MI. Association of hypoxia-inducible factors 1alpha and 2alpha with activated angiogenic pathways and prognosis in patients with endometrial carcinoma. Cancer 2002; 95: 1055-63.
3. Folkman J. Angiogenesis in cancer, vascular rheumatoid and other disease. Nature Med 1995; 1: 27-31.
4. Folkman J, Klagsburn M. Angiogenic factors. Science 1987; 235: 442-7.
5. Hanahan D, Folkman J. Pattern and emerging mechanisms of the angiogenic switch during tumorigenesis. Cell 1966; 86: 353-64.
6. Dallenbach-Hellweg G. Histopathology of the Endometrium, 4th edn. Berlin, Heidelberg, New York: Springer-Verlag, 1987; 86-92.
7. Bell CD, Ostrega E. The significance of secretory features and coincident hyperplastic change in endometrial biopsy specimens. Hum Pathol 1987; 18: 830-38.
8. Weidner N. Intratumor microvessels density as a prognostic factor on cancer. Am J Pathol 1995; 147: 9-19.
9. Weidner N, Semple JP, Welch WR et al. Tumor angiogenesis and metastasis-correlation in invasive breast breast carcinoma. N Engl J Med 1991; 324: 1-8.
10. Mints M, Blomgren B, Falconer C, Palmblad J. Expression of the vascular endothelial growth factor (VEGF) family in human endometrial blood vessels. Scand J Clin Lab Invest 2002; 62: 167-75.
11. Wentz WB. Progestin therapy in endometrial hyperplasia. Gynecol Oncol 1974; 2: 362-7.
12. Gusberg SB, Kaplan AL. Precursors of corpus cancer. Am J Obstet Gynecol 1963; 87: 662-78.
13. Kurman RJ, Norris HJ. Endometrial neoplasia, hyperplasia and carcinoma. In: Blaustein A, ed. Pathology of the Female Genital Tract, 2nd edn. New York: Springer-Verlag, 1982; 311-51.
14. Kurman RJ, Kaminski PF, Norris HJ. The behavior of endometrial hyperplasia: a long term study of 'untreated' hyperplasia in 170 patients. Cancer 1985; 56: 403-12.
15. Lessey BA. Immunohistochemical analysis of human uterine estrogen and progesterone receptors throughout the menstral cycle. J Clin Endocrinol Metab 1988; 67: 334-40.
16. Nyholm HC, Nielsen AL, Lyndrup J, Norup P, Thorpe SM. Biochemical and immunohistochemical estrogen and progesterone receptors in adenomatous hyperplasia and endometrial carcinoma: correlations with stage and other clinicopathologic features. Am J Obstet Gynecol 1992; 167: 1334-42.
17. Nyholm HC, Nielsen AL, Lyndrup J, Dreisler A, Thorpe SM. Estrogen and progesterone receptors in endometrial carcinoma: comparison of immunohistochemical and biochemical analysis. Int J Gynecol Pathol 1993; 12: 246-52.
18. Bergeron C, Ferenczy A, Toft DO, Shyarnala G. Immunocytochemical study of progesterone receptors in hyperplastic and neoplastic endometrial tissues. Cancer Res 1988; 48: 6132-6.
19. Bergeron C, Ferenczy A, Toft DO, Schneider W, Shyamala G. Immunocytochemical study of progesterone receptors in the human endometrium during the menstrual cycle. Lab Invest 1988; 59: 862-9.
20. Cao QJ, Einstein MH, Anderson PS, Runowicz CD, Balan R, Jones JG. Expression of COX-2, Ki-67, cyclin D1, and p21 in endometrial endometrioid carcinomas. Int J Gynecol Pathol 2002; 21: 147-54.
21. Ruhul Quddus M, Latkovich P, Castellani WJ et al. Expression of cyclin D1 in normal, metaplastic, hyperplastic endometrium and endometrioid carcinoma suggests a role in endometrial carcinogenesis. Arch Pathol Lab Med 2002; 126: 459-63.
22. Nicosia RF. What is the role of vascular endothelial growth factor-related molecules in tumor angiogenesis? Am J Pathol 1998; 153: 11-16.
23. Risau W, Flamme I. Vasculogenesis. Ann Rev Cell Dev Biol 1995; 11: 73-91.
24. Nunobiki O, Sato M, Taniguchi E, Nakamura Y, Mori I, Kakudo K. Morphometric characterization of endometrial glands using quantitative cytology. Anal Quant Cytol Histol 2001; 23: 201-6.