Glucocorticoid receptors, in vitro steroid sensitivity, and cytokine secretion in idiopathic nephrotic syndrome

Kidney International

Volumn 65, Issue 2, 2004, Pages 403-408

  Carlotti, Ana Paula De Carvalho Panzeri ^a   Franco, Paulo Benedito ^a   Elias, Lucila Leico ^a   Facincani, Inalda ^a   Costa, Elaine Lourenço Cardeal ^a   Foss, Norma ^a   Moreira, Ayrton Custódio ^a   De Castro, Margaret ^a  

^a UNIVERSITY OF SÃO PAULO   (Brazil)

Author keywords

Glucocorticoid receptor number and affinity; Idiopathic nephrotic syndrome; In vitro steroid sensitivity; Th1 Th2 cytokines

Indexed keywords

CONCANAVALIN A; DEXAMETHASONE; GAMMA INTERFERON; GLUCOCORTICOID; GLUCOCORTICOID RECEPTOR; HYDROCORTISONE; INTERLEUKIN 10; INTERLEUKIN 6; TUMOR NECROSIS FACTOR ALPHA;

ADOLESCENT; ARTICLE; BLOOD; CELL ASSAY; CELL CULTURE; CELL ISOLATION; CELL PROLIFERATION; CELL STIMULATION; CHILD; CONTROLLED STUDY; CYTOKINE RELEASE; DOSE RESPONSE; DRUG SENSITIVITY; ENZYME LINKED IMMUNOSORBENT ASSAY; FEMALE; HUMAN; HUMAN CELL; HYDROCORTISONE RELEASE; IDIOPATHIC DISEASE; IN VITRO STUDY; LYMPHOCYTE PROLIFERATION; MALE; MEASUREMENT; NEPHROTIC SYNDROME; PERIPHERAL BLOOD MONONUCLEAR CELL; PRIORITY JOURNAL; RADIOIMMUNOASSAY; RECEPTOR AFFINITY; RECEPTOR BINDING; RECEPTOR DENSITY; RELAPSE; SALIVA; SALIVA LEVEL; STATISTICAL SIGNIFICANCE; SUPERNATANT;

EID: 1642480086     PISSN: 00852538     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1523-1755.2004.00392.x     Document Type: Article

References (36)

1. KELSCH RC, SEDMAN AB: Nephrotic syndrome. Pediatr Rev 14:30-38, 1993
2. NIAUDET P: Nephrotic syndrome in children. Curr Opin Pediatr 5:174-179, 1993
3. DESCHENES G, MARTINAT L: Mécanismes moléculaires du syndrome néphrotique idiopathique. Arch Pediatr 7:1318-1329, 2000
4. BAMBERGER CM, SCHULTE HM, CHROUSOS GP: Molecular determinants of glucocorticoid receptor function and tissue sensitivity to glucocorticoids. Endocr Rev 17:245-261, 1996
5. BOUMPAS DT, CHROUSOS GP, WILDER RL, et al. Glucocorticoid therapy for immune-mediated diseases: Basic and clinical correlates. Ann Intern Med 119:1198-1208, 1993
6. JONAT C, RAHMSDORF HJ, PARK KK, et al. Antitumor promotion and antiinflammation: Down-modulation of AP-1 (Fos/Jun) activity by glucocorticoid hormone. Cell 62:1189-1204, 1990
7. BARNES PJ, KARIN M: Nuclear factor-kappaB: A pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 336:1066-1071, 1997
8. SCHLAGHECKE R, KORNELY E, WOLLENHAUPT J, SPECKER C: Glucocorticoid receptors in rheumatoid arthritis. Arthritis Rheum 35:740-744, 1992
9. SHER ER, LEUNG DY, SURS W, et al. Steroid-resistant asthma. Cellular mechanisms contributing to inadequate response to glucocorticoid therapy. J Clin Invest 93:33-39, 1994
10. BAGDASAROVA IV, IVANOV DD, AFANAS'EVA VV: The morphofunctional characteristics of the blood lymphocytes in steroid-sensitive and steroid-resistant glomerulonephritis. Arkh Patol 53:28-32, 1991
11. HAACK D, SCHARER K, ASAM-TAUSCHER A, VECSEI P: Glucocorticoid receptors in idiopathic nephrotic syndrome. Pediatr Nephrol 13:653-656, 1999
12. STACHOWSKI J, BARTH C, MICHALKIEWICZ J, et al. Th1/Th2 balance and CD45-positive T cell subsets in primary nephrotic syndrome. Pediatr Nephrol 14:779-785, 2000
13. FUTRAKUL N, BUTTHEP P, PATUMRAJ S, FUTRAKUL P: Glomerular endothelial dysfunction and altered cytokines in severe nephrosis. Nephron 86:199, 2000
14. DANIEL V, TRAUTMANN Y, KONRAD M. et al: T-lymphocyte populations, cytokines and other growth factors in serum and urine of children with idiopathic nephrotic syndrome. Clin Nephrol 47:289-297, 1997
15. MATSUMOTO K: Decreased release of IL-10 by monocytes from patients with lipoid nephrosis. Clin Exp Immunol 102:603-607, 1995
16. INTERNATIONAL STUDY OF KIDNEY DISEASE IN CHILDREN. The primary nephrotic syndrome in children. Identification of patients with minimal change nephrotic syndrome from initial response to prednisone. A report of the International Study of Kidney Disease in Children. J Pediatr 98:561-564, 1981
17. MARTINELLI CE, JR., SADER SL, OLIVEIRA EB, et al: Salivary cortisol for screening of Cushing's syndrome in children. Clin Endocrinol (Oxf) 51:67-71, 1999
18. SANTIAGO LB, JORGE SM, MOREIRA AC: Longitudinal evaluation of the development of salivary cortisol circadian rhythm in infancy. Clin Endocrinol (Oxf) 44:157-61, 1996
19. ANTONINI SR, JORGE SM, MOREIRA AC: The emergence of salivary cortisol circadian rhythm and its relationship to sleep activity in preterm infants. Clin Endocrinol (Oxf) 52:423-426, 2000
20. STEINER AE, WITTLIFF JL: A whole-cell assay for glucocorticoid binding sites in normal human lymphocytes. Clin Chem 31:1855-1860, 1985
21. CHROUSOS GP: The hypothalamic-pituitary-adrenal axis and immune-mediated inflammation. N Engl J Med 332:1351-1362, 1995
22. ELENKOV IJ, CHROUSOS GP: Stress hormones, Th1/Th2 patterns, pro/anti-inflammatory cytokines and susceptibility to disease. Trends Endocrinol Metab 10:359-368, 1999
23. VINING RF, MCGINLEY RA, MAKSVYTIS JJ, HO KY: Salivary cortisol: A better measure of adrenal cortical function than serum cortisol. Ann Clin Biochem 20:329-335, 1983
24. SVEC F: Glucocorticoid receptor regulation. Life Sci 36:2359-2366, 1985
25. TANAKA H, AKAMA H, ICHIKAWA Y, et al: Glucocorticoid receptors in normal leukocytes: Effects of age, gender, season, and plasma cortisol concentrations. Clin Chem 37:1715-1719, 1991
26. DE CASTRO M, ELLIOT S, KINO T, et al: The non-ligand binding beta-isoform of the human glucocorticoid receptor (hGR beta): Tissue levels, mechanism of action, and potential physiologic role. Mol Med 2:597-607, 1996
27. SOUSA AR, LANE SJ, CIDLOWSKI JA, et al: Glucocorticoid resistance in asthma is associated with elevated in vivo expression of the glucocorticoid receptor beta-isoform. J Allergy Clin Immunol 105:943-950, 2000
28. KARLE SM, UETZ B, RONNER V, et al: Novel mutations in NPHS2 detected in both familial and sporadic steroid-resistant nephrotic syndrome. J Am Soc Nephrol 13:388-393, 2002
29. HUBER TB, KOTTGEN M, SCHILLING B, et al: Interaction with podocin facilitates nephrin signaling. J Biol Chem 276:41543-41546, 2001
30. DE ANTONIO SR, BLOTTA HM, MAMONI RL, et al: Effects of dexamethasone on lymphocyte proliferation and cytokine production in patients with rheumatoid arthritis. J Rheumatol 29:46-51, 2002
31. LEUNG DY: Immunologic basis of chronic allergic diseases: Clinical messages from the laboratory bench. Pediatr Res 42:559-568, 1997
32. KOUSKOFF V, KORGANOW AS, DUCHATELLE V, et al: Organ-specific disease provoked by systemic autoimmunity. Cell 87:811-822, 1996
33. KANEKO K, TUCHIYA K, FUJINAGA S, et al: Th1/Th2 balance in childhood idiopathic nephrotic syndrome. Clin Nephrol 58:393-397, 2002
34. BIRMELE B, THIBAULT G, NIVET H, et al: In vitro decrease of glomerular heparan sulfate by lymphocytes from idiopathic nephrotic syndrome patients. Kidney Int 59:913-922, 2001
35. FRANCHIMONT D, MARTENS H, HAGELSTEIN MT, et al: Tumor necrosis factor alpha decreases, and interleukin-10 increases, the sensitivity of human monocytes to dexamethasone: Potential regulation of the glucocorticoid receptor. J Clin Endocrinol Metab 84:2834-2839, 1999
36. MEDURI GU, TOLLEY EA, CHROUSOS GP, et al: Prolonged methylprednisolone treatment suppresses systemic inflammation in patients with unresolving acute respiratory distress syndrome: Evidence for inadequate endogenous glucocorticoid secretion and inflammation-induced immune cell resistance to glucocorticoids. Am J Respir Crit Care Med 165:983-991, 2002