Flumazenil does not affect intracortical motor excitability in humans: A transcranial magnetic stimulation study

Clinical Neurophysiology

Volumn 115, Issue 2, 2004, Pages 325-329

  Jung, H Y ^a   Sohn, Y H ^b   Mason, A ^b   Considine, E ^b   Hallett, M ^b  

^a Inha University School of Medicine   (South Korea)

^b NATIONAL INSTITUTE OF NEUROLOGICAL DISORDERS AND STROKE   (United States)

Author keywords

Benzodiazepine; Cortical excitability; Flumazenil; Transcranial magnetic stimulation; Aminobutyric acid

Indexed keywords

BENZODIAZEPINE RECEPTOR BLOCKING AGENT; FLUMAZENIL; SODIUM CHLORIDE;

ADULT; ARTICLE; BRAIN CORTEX; BRAIN DEPTH STIMULATION; CONTROLLED STUDY; DOSE RESPONSE; DRUG EFFECT; DRUG INFUSION; FEMALE; HEALTH STATUS; HUMAN; HUMAN EXPERIMENT; MALE; MOTOR ACTIVITY; MUSCLE ACTION POTENTIAL; NERVE STIMULATION; NORMAL HUMAN; PRIORITY JOURNAL; RANDOMIZATION; TRANSCRANIAL MAGNETIC STIMULATION;

EID: 1642464685     PISSN: 13882457     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1388-2457(03)00335-3     Document Type: Article

References (23)

1. Brasil-Neto J.P., Cohen L.G., Panizza M., Nilsson J., Roth B.J., Hallett M. Optimal focal transcranial magnetic activation of the human motor cortex: effects of coil orientation, shape of the induced current pulse, and stimulus intensity. J Clin Neurophysiol. 9:1992;132-136.
2. Breimer L.T., Hennis P.J., Burm A.G., Danhof M., Bovill J.G., Spierdijk J., Vletter A.A. Pharmacokinetics and EEG effects of flumazenil in volunteers. Clin Pharmacokinet. 20:1991;491-496.
3. Bütefisch C.M., Davis B.C., Wise S.P., Sawaki L., Kopylev L., Classen J., Cohen L.G. Mechanisms of use-dependent plasticity in the human motor cortex. Proc Natl Acad Sci USA. 97:2000;3661-3665.
4. Cone A.M., Stott S.A. Flumazenil. Br J Hosp Med. 51:1994;346-348.
5. Di Lazzaro V., Oliviero A., Meglio M., Cioni B., Tamburrini G., Tonali P., Rothwell J.C. Direct demonstration of the effect of lorazepam on the excitability of the human motor cortex. Clin Neurophysiol. 111:2000;794-799.
6. File S.E., Lister R.G., Nutt D.J. Intrinsic actions of benzodiazepine antagonists. Neurosci Lett. 32:1982;165-168.
7. Gomez-Fernandez L. Cortical plasticity and restoration of neurologic functions: an update on this topic. Rev Neurol. 31:2000;749-756.
8. Hallett M. Motor cortex plasticity. Electroenceph clin Neurophysiol Suppl. 50:1999;85-91.
9. Hallett M., Chen R., Ziemann U., Cohen L.G. Reorganization in motor cortex in amputees and in normal volunteers after ischemic limb deafferentation. Electroenceph clin Neurophysiol Suppl. 51:1999;183-187.
10. Hoffman E.J., Warren E.W. Flumazenil: a benzodiazepine antagonist. Clin Pharm. 12:1993;641-656.
11. Klotz U., Ziegler G., Rosenkranz B., Mikus G. Does the benzodiazepine antagonist Ro 15-1788 antagonize the action of ethanol? Br J Clin Pharmacol. 22:1986;513-520.
12. Liepert J., Graef S., Uhde I., Leidner O., Weiller C. Training-induced changes of motor cortex representations in stroke patients. Acta Neurol Scand. 101:2000;321-326.
13. 3H-diazepam binding to benzodiazepine receptors in rat cerebral cortex. Life Sci. 20:1977;2101-2110.
14. Neave N., Reid C., Scholey A.B., Thompson J.M., Moss M., Ayre G., Wesnes K., Girdler N.M. Dose-dependent effects of flumazenil on cognition, mood, and cardio- respiratory physiology in healthy volunteers. Br Dent J. 189:2000;668-674.
15. Nudo R.J., Wise B.M., Sifuentes F., Milliken G.W. Neural substrates for the effects of rehabilitative training on motor recovery after ischemic infarct. Science. 272:1996;1791-1794.
16. Palmieri M.G., Iani C., Scalise A., Desiato M.T., Loberti M., Telera S., Caramia M.D. The effect of benzodiazepines and flumazenil on motor cortical excitability in the human brain. Brain Res. 815:1999;192-199.
17. Rex N., Brogden K.L.G. Flumazenil: a preliminary review of its benzodiazepine antagonist properties, intrinsic and therapeutic use. Drugs. 35:1988;448-467.
18. Roncari G., Ziegler W.H., Guentert T.W. Pharmacokinetics of the new benzodiazepine antagonist Ro 15-1788 in man following intravenous and oral administration. Br J Clin Pharmacol. 22:1986;421-428.
19. A receptor shows a ligand-gated receptor super-family. Nature. 328:1987;221-227.
20. Schopf J., Laurian S., Le P.K., Gaillard J.M. Intrinsic activity of the benzodiazepine antagonist Ro 15-1788 in man: an electrophysiological investigation. Pharmacopsychiatry. 17:1984;79-83.
21. Smolnik R., Pietrowsky R., Fehm H.L., Born J. Enhanced selective attention after low-dose administration of the benzodiazepine antagonist flumazenil. J Clin Psychopharmacol. 18:1998;241-247.
22. Taub E., Morris D.M. Constraint-induced movement therapy to enhance recovery after stroke. Curr Atheroscler Rep. 3:2001;279-286.
23. Ziemann U., Lonnecker S., Steinhoff B.J., Paulus W. The effect of lorazepam on the motor cortical excitability in man. Exp Brain Res. 109:1996;127-135.