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Volumn 14, Issue 1, 2004, Pages 47-64

Prospects for antiviral ribozymes and deoxyribozymes

Author keywords

[No Author keywords available]

Indexed keywords

ANTISENSE OLIGONUCLEOTIDE; ANTIVIRUS AGENT; DEOXYRIBOZYME; ENZYME VARIANT; HAMMERHEAD RIBOZYME; HEPTAZYME; INTERFERON; LIPOSOME; MESSENGER RNA; RECOMBINANT ENZYME; RIBOZYME; RNA; SMALL INTERFERING RNA; UNCLASSIFIED DRUG;

EID: 1642458402     PISSN: 10529276     EISSN: None     Source Type: Journal    
DOI: 10.1002/rmv.415     Document Type: Review
Times cited : (67)

References (168)
  • 1
    • 0024210034 scopus 로고
    • Ribozymes and their medical implications
    • Cech TR. Ribozymes and their medical implications. JAMA 1988; 260: 3030-3034.
    • (1988) JAMA , vol.260 , pp. 3030-3034
    • Cech, T.R.1
  • 2
    • 0025363891 scopus 로고
    • Ribozymes as potential anti-HIV-1 therapeutic agents
    • Sarver N, Cantin EM, Chang PS, et al. Ribozymes as potential anti-HIV-1 therapeutic agents. Science 1990; 247: 1222-1225.
    • (1990) Science , vol.247 , pp. 1222-1225
    • Sarver, N.1    Cantin, E.M.2    Chang, P.S.3
  • 3
    • 0031973036 scopus 로고    scopus 로고
    • The therapeutic potential of ribozymes
    • James HA, Gibson I. The therapeutic potential of ribozymes. Blood 1998; 91: 371-392.
    • (1998) Blood , vol.91 , pp. 371-392
    • James, H.A.1    Gibson, I.2
  • 4
    • 0032993464 scopus 로고    scopus 로고
    • The application of ribozymes to HIV infection
    • Rossi JJ. The application of ribozymes to HIV infection. Curr Opin Mol Ther 1999; 1: 316-322.
    • (1999) Curr Opin Mol Ther , vol.1 , pp. 316-322
    • Rossi, J.J.1
  • 5
    • 0034954123 scopus 로고    scopus 로고
    • Biological applications of hammerhead ribozymes as anti-viral molecules
    • Lustig B, Jeang KT. Biological applications of hammerhead ribozymes as anti-viral molecules. Curr Med Chem 2001; 8: 1181-1187.
    • (2001) Curr Med Chem , vol.8 , pp. 1181-1187
    • Lustig, B.1    Jeang, K.T.2
  • 7
    • 0033709117 scopus 로고    scopus 로고
    • Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function
    • Khachigian LM. Catalytic DNAs as potential therapeutic agents and sequence-specific molecular tools to dissect biological function. J Clin Invest 2000; 106: 1189-1195.
    • (2000) J Clin Invest , vol.106 , pp. 1189-1195
    • Khachigian, L.M.1
  • 9
    • 0027973382 scopus 로고
    • Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes
    • Zhou C, Bahner IC, Larson GP, Zaia JA, Rossi JJ, Kohn EB. Inhibition of HIV-1 in human T-lymphocytes by retrovirally transduced anti-tat and rev hammerhead ribozymes. Gene 1994; 149: 33-39.
    • (1994) Gene , vol.149 , pp. 33-39
    • Zhou, C.1    Bahner, I.C.2    Larson, G.P.3    Zaia, J.A.4    Rossi, J.J.5    Kohn, E.B.6
  • 10
    • 0029970824 scopus 로고    scopus 로고
    • Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes
    • Lieber A, He CY, Polyak SJ, Gretch DR, Barr D, Kay MA. Elimination of hepatitis C virus RNA in infected human hepatocytes by adenovirus-mediated expression of ribozymes. J Virol 1996; 70: 8782-8791.
    • (1996) J Virol , vol.70 , pp. 8782-8791
    • Lieber, A.1    He, C.Y.2    Polyak, S.J.3    Gretch, D.R.4    Barr, D.5    Kay, M.A.6
  • 11
    • 0027264877 scopus 로고
    • A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1
    • Yu M, Ojwang J, Yamada O, et al. A hairpin ribozyme inhibits expression of diverse strains of human immunodeficiency virus type 1. Proc Natl Acad Sci USA 1993; 90: 6340-6344.
    • (1993) Proc Natl Acad Sci USA , vol.90 , pp. 6340-6344
    • Yu, M.1    Ojwang, J.2    Yamada, O.3
  • 12
    • 0033022041 scopus 로고    scopus 로고
    • Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus
    • zu Putlitz J, Yu Q, Burke JM, Wands JR. Combinatorial screening and intracellular antiviral activity of hairpin ribozymes directed against hepatitis B virus. J Virol 1999; 73: 5381-5387.
    • (1999) J Virol , vol.73 , pp. 5381-5387
    • Zu Putlitz, J.1    Yu, Q.2    Burke, J.M.3    Wands, J.R.4
  • 13
    • 0036702342 scopus 로고    scopus 로고
    • RNase P ribozymes for the studies and treatment of human cytomegalovirus infections
    • Trang P, Kilani A, Lee J, et al. RNase P ribozymes for the studies and treatment of human cytomegalovirus infections. J Clin Virol 2002; 25 Suppl 2: S63-S74.
    • (2002) J Clin Virol , vol.25 , Issue.SUPPL. 2
    • Trang, P.1    Kilani, A.2    Lee, J.3
  • 14
    • 0034839007 scopus 로고    scopus 로고
    • Ribozyme gene therapy: Applications for molecular medicine
    • Lewin AS, Hauswirth WW. Ribozyme gene therapy: applications for molecular medicine. Trends Mol Med 2001; 7: 221-228.
    • (2001) Trends Mol Med , vol.7 , pp. 221-228
    • Lewin, A.S.1    Hauswirth, W.W.2
  • 15
    • 0037062920 scopus 로고    scopus 로고
    • Emerging clinical applications of RNA
    • Sullenger BA, Gilboa E. Emerging clinical applications of RNA. Nature 2002; 418: 252-258.
    • (2002) Nature , vol.418 , pp. 252-258
    • Sullenger, B.A.1    Gilboa, E.2
  • 16
    • 0141739492 scopus 로고    scopus 로고
    • Intracellular production of DNA enzyme by a novel single-stranded DNA expression vector
    • Chen Y, McMicken HW. Intracellular production of DNA enzyme by a novel single-stranded DNA expression vector. Gene Ther 2003; 10: 1776-1780.
    • (2003) Gene Ther , vol.10 , pp. 1776-1780
    • Chen, Y.1    McMicken, H.W.2
  • 17
    • 0242526935 scopus 로고    scopus 로고
    • RNA interference: On the road to an alternate therapeutic strategy!
    • Dave RS, Pomerantz RJ. RNA interference: on the road to an alternate therapeutic strategy! Rev Med Virol 2003; 13: 373-385.
    • (2003) Rev Med Virol , vol.13 , pp. 373-385
    • Dave, R.S.1    Pomerantz, R.J.2
  • 18
    • 0037238848 scopus 로고    scopus 로고
    • Gene silencing mediated by small interfering RNAs in mammalian cells
    • Scherr M, Morgan MA, Eder M. Gene silencing mediated by small interfering RNAs in mammalian cells. Curr Med Chem 2003; 10: 245-256.
    • (2003) Curr Med Chem , vol.10 , pp. 245-256
    • Scherr, M.1    Morgan, M.A.2    Eder, M.3
  • 19
    • 0038002630 scopus 로고    scopus 로고
    • Nucleic acid-based immune system: The antiviral potential of mammalian RNA silencing
    • Gitlin L, Andino R. Nucleic acid-based immune system: the antiviral potential of mammalian RNA silencing. J Virol 2003; 77: 7159-7165.
    • (2003) J Virol , vol.77 , pp. 7159-7165
    • Gitlin, L.1    Andino, R.2
  • 20
    • 0023663396 scopus 로고
    • Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites
    • Forster AC, Symons RH. Self-cleavage of plus and minus RNAs of a virusoid and a structural model for the active sites. Cell 1987; 49: 211-220.
    • (1987) Cell , vol.49 , pp. 211-220
    • Forster, A.C.1    Symons, R.H.2
  • 21
    • 0021351807 scopus 로고
    • A replication cycle for viroids and other small infectious RNAs
    • Branch AD, Robertson HD. A replication cycle for viroids and other small infectious RNAs. Science 1984; 223: 450-455.
    • (1984) Science , vol.223 , pp. 450-455
    • Branch, A.D.1    Robertson, H.D.2
  • 22
    • 0024436928 scopus 로고
    • Self-cleavage of RNA in the replication of small pathogens of plants and animals
    • Symons RH. Self-cleavage of RNA in the replication of small pathogens of plants and animals. Trends Biochem Sci 1989; 14: 445-450.
    • (1989) Trends Biochem Sci , vol.14 , pp. 445-450
    • Symons, R.H.1
  • 23
    • 0023221419 scopus 로고
    • A small catalytic oligoribonucleotide
    • Uhlenbeck OC. A small catalytic oligoribonucleotide. Nature 1987; 328: 596-600.
    • (1987) Nature , vol.328 , pp. 596-600
    • Uhlenbeck, O.C.1
  • 24
    • 0024291288 scopus 로고
    • Simple RNA enzymes with new and highly specific endoribonuclease activities
    • Haseloff J, Gerlach WL. Simple RNA enzymes with new and highly specific endoribonuclease activities. Nature 1988; 334: 585-591.
    • (1988) Nature , vol.334 , pp. 585-591
    • Haseloff, J.1    Gerlach, W.L.2
  • 25
    • 0036903567 scopus 로고    scopus 로고
    • Folding and activity of the hammerhead ribozyme
    • Hammann C, Lilley DM. Folding and activity of the hammerhead ribozyme. Chembiochem 2002; 3: 690-700.
    • (2002) Chembiochem , vol.3 , pp. 690-700
    • Hammann, C.1    Lilley, D.M.2
  • 28
    • 0028063567 scopus 로고
    • Three-dimensional structure of a hammerhead ribozyme
    • Pley HW, Flaherty KM, McKay DB. Three-dimensional structure of a hammerhead ribozyme. Nature 1994; 372: 68-74.
    • (1994) Nature , vol.372 , pp. 68-74
    • Pley, H.W.1    Flaherty, K.M.2    McKay, D.B.3
  • 29
    • 0029073091 scopus 로고
    • The crystal structure of an all-RNA hammerhead ribozyme: A proposed mechanism for RNA catalytic cleavage
    • Scott WG, Finch JT, Klug A. The crystal structure of an all-RNA hammerhead ribozyme: a proposed mechanism for RNA catalytic cleavage. Cell 1995; 81: 991-1002.
    • (1995) Cell , vol.81 , pp. 991-1002
    • Scott, W.G.1    Finch, J.T.2    Klug, A.3
  • 30
    • 0030476765 scopus 로고    scopus 로고
    • Capturing the structure of a catalytic RNA intermediate: The hammerhead ribozyme
    • Scott WG, Murray JB, Arnold JRP, Stoddard BL, Klug A. Capturing the structure of a catalytic RNA intermediate: the hammerhead ribozyme. Science 1996; 274: 2065-2069.
    • (1996) Science , vol.274 , pp. 2065-2069
    • Scott, W.G.1    Murray, J.B.2    Arnold, J.R.P.3    Stoddard, B.L.4    Klug, A.5
  • 31
    • 0029949701 scopus 로고    scopus 로고
    • Structure and function of the hammerhead ribozyme: An unfinished story
    • McKay D. Structure and function of the hammerhead ribozyme: an unfinished story. RNA 1996; 2: 395-403.
    • (1996) RNA , vol.2 , pp. 395-403
    • McKay, D.1
  • 32
    • 0032530198 scopus 로고    scopus 로고
    • Sequence specificity of the hammerhead ribozyme revisited: The NHH rule
    • Kore AR, Vaish NK, Kutzke U, Eckstein F. Sequence specificity of the hammerhead ribozyme revisited: the NHH rule. Nucleic Acids Res 1998; 26: 4116-4120.
    • (1998) Nucleic Acids Res , vol.26 , pp. 4116-4120
    • Kore, A.R.1    Vaish, N.K.2    Kutzke, U.3    Eckstein, F.4
  • 33
    • 0032523415 scopus 로고    scopus 로고
    • Extending the cleavage rules for the hammerhead ribozyme: Mutating adenosine15.1 to inosine15.1 changes the cleavage site specificity from N16.2U16.1H17 to N16.2C16.1H17
    • Ludwig J, Blaschke M, Sproat BS. Extending the cleavage rules for the hammerhead ribozyme: mutating adenosine15.1 to inosine15.1 changes the cleavage site specificity from N16.2U16.1H17 to N16.2C16.1H17. Nucleic Acids Res 1998; 26: 2279-2285.
    • (1998) Nucleic Acids Res , vol.26 , pp. 2279-2285
    • Ludwig, J.1    Blaschke, M.2    Sproat, B.S.3
  • 34
    • 0035020626 scopus 로고    scopus 로고
    • The hammerhead cleavage reaction in monovalent cations
    • Curtis EA, Bartel DP. The hammerhead cleavage reaction in monovalent cations. RNA 2001; 7: 546-552.
    • (2001) RNA , vol.7 , pp. 546-552
    • Curtis, E.A.1    Bartel, D.P.2
  • 35
    • 0035001461 scopus 로고    scopus 로고
    • Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations
    • O'Rear JL, Wang S, Feig AL, Beigelman L, Uhlenbeck OC, Herschlag D. Comparison of the hammerhead cleavage reactions stimulated by monovalent and divalent cations. RNA 2001; 7: 537-545.
    • (2001) RNA , vol.7 , pp. 537-545
    • O'Rear, J.L.1    Wang, S.2    Feig, A.L.3    Beigelman, L.4    Uhlenbeck, O.C.5    Herschlag, D.6
  • 36
    • 0036606134 scopus 로고    scopus 로고
    • Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme
    • Zhou JM, Zhou DM, Takagi Y, et al. Existence of efficient divalent metal ion-catalyzed and inefficient divalent metal ion-independent channels in reactions catalyzed by a hammerhead ribozyme. Nucleic Acids Res 2002; 30: 2374-2382.
    • (2002) Nucleic Acids Res , vol.30 , pp. 2374-2382
    • Zhou, J.M.1    Zhou, D.M.2    Takagi, Y.3
  • 37
    • 0025998488 scopus 로고
    • Role of divalent metal ions in the hammerhead RNA cleavage reaction
    • Dahm SC, Uhlenbeck OC. Role of divalent metal ions in the hammerhead RNA cleavage reaction. Biochemistry 1991; 30: 9464-9469.
    • (1991) Biochemistry , vol.30 , pp. 9464-9469
    • Dahm, S.C.1    Uhlenbeck, O.C.2
  • 38
    • 0032559057 scopus 로고    scopus 로고
    • 2+ binding affinities to the hammerhead ribozyme and correlation with cleavage activity
    • 2+ binding affinities to the hammerhead ribozyme and correlation with cleavage activity. Biochemistry 1998; 37: 18094-18101.
    • (1998) Biochemistry , vol.37 , pp. 18094-18101
    • Horton, T.E.1    Clardy, D.R.2    DeRose, V.J.3
  • 39
    • 0033607198 scopus 로고    scopus 로고
    • Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate
    • Wang S, Karbstein K, Peracchi A, Beigelman L, Herschlag D. Identification of the hammerhead ribozyme metal ion binding site responsible for rescue of the deleterious effect of a cleavage site phosphorothioate. Biochemistry 1999; 38: 14363-14378.
    • (1999) Biochemistry , vol.38 , pp. 14363-14378
    • Wang, S.1    Karbstein, K.2    Peracchi, A.3    Beigelman, L.4    Herschlag, D.5
  • 40
    • 0033575087 scopus 로고    scopus 로고
    • Kinetics of RNA degradation by specific base catalysis of transesterification involving the 2′-hydroxyl group
    • Li Y, Breaker R. Kinetics of RNA degradation by specific base catalysis of transesterification involving the 2′-hydroxyl group. J Am Chem Soc 1999; 121: 5364-5372.
    • (1999) J Am Chem Soc , vol.121 , pp. 5364-5372
    • Li, Y.1    Breaker, R.2
  • 41
    • 0031841806 scopus 로고    scopus 로고
    • Degradation of hammerhead ribozymes by human ribonucleases
    • Qiu L, Moreira A, Kaplan G, et al. Degradation of hammerhead ribozymes by human ribonucleases. Mol Gen Genet 1998; 258: 352-362.
    • (1998) Mol Gen Genet , vol.258 , pp. 352-362
    • Qiu, L.1    Moreira, A.2    Kaplan, G.3
  • 42
    • 0028858581 scopus 로고
    • Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance
    • Beigelman L, McSwiggen JA, Draper KG, et al. Chemical modification of hammerhead ribozymes. Catalytic activity and nuclease resistance. J Biol Chem 1995; 270: 25702-25708.
    • (1995) J Biol Chem , vol.270 , pp. 25702-25708
    • Beigelman, L.1    McSwiggen, J.A.2    Draper, K.G.3
  • 43
    • 0030668679 scopus 로고    scopus 로고
    • Chemical engineering of RNase resistant and catalytically active hammerhead ribozymes
    • Burlina F, Favre A, Fourrey J-L. Chemical engineering of RNase resistant and catalytically active hammerhead ribozymes. Bioorg Med Chem 1997; 5: 1999-2010.
    • (1997) Bioorg Med Chem , vol.5 , pp. 1999-2010
    • Burlina, F.1    Favre, A.2    Fourrey, J.-L.3
  • 44
    • 0033692912 scopus 로고    scopus 로고
    • Nuclease-resistant synthetic ribozymes: Developing a new class of therapeutics
    • Usman N, Blatt LM. Nuclease-resistant synthetic ribozymes: developing a new class of therapeutics. J Clin Invest 2000; 106: 1197-1202.
    • (2000) J Clin Invest , vol.106 , pp. 1197-1202
    • Usman, N.1    Blatt, L.M.2
  • 45
    • 0027227872 scopus 로고
    • Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages
    • Shimayama T, Nishikawa F, Nishikawa S, Taira K. Nuclease-resistant chimeric ribozymes containing deoxyribonucleotides and phosphorothioate linkages. Nucleic Acids Res 1993; 21: 2605-2611.
    • (1993) Nucleic Acids Res , vol.21 , pp. 2605-2611
    • Shimayama, T.1    Nishikawa, F.2    Nishikawa, S.3    Taira, K.4
  • 47
    • 10544234615 scopus 로고    scopus 로고
    • Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb
    • Jarvis TC, Wincott FE, Alby LJ, et al. Optimizing the cell efficacy of synthetic ribozymes. Site selection and chemical modifications of ribozymes targeting the proto-oncogene c-myb. J Biol Chem 1996; 271: 29107-29112.
    • (1996) J Biol Chem , vol.271 , pp. 29107-29112
    • Jarvis, T.C.1    Wincott, F.E.2    Alby, L.J.3
  • 48
    • 0032697942 scopus 로고    scopus 로고
    • A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides
    • Levin AA. A review of the issues in the pharmacokinetics and toxicology of phosphorothioate antisense oligonucleotides. Biochim Biophys Acta 1999; 1489: 69-84.
    • (1999) Biochim Biophys Acta , vol.1489 , pp. 69-84
    • Levin, A.A.1
  • 49
    • 0034625010 scopus 로고    scopus 로고
    • Potent and non-toxic antisense oligonucleotides containing locked nucleic acids
    • Wahlestedt C, Salmi P, Good L, et al. Potent and non-toxic antisense oligonucleotides containing locked nucleic acids. Proc Natl Acad Sci USA 2000; 97: 5633-5638.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 5633-5638
    • Wahlestedt, C.1    Salmi, P.2    Good, L.3
  • 50
    • 0030747101 scopus 로고    scopus 로고
    • A specificity comparison of four antisense types: Morpholino, 2′-O-methyl RNA, DNA, and phosphorothioate DNA
    • Stein D, Foster E, Huang SB, Weller D, Summerton J. A specificity comparison of four antisense types: morpholino, 2′-O-methyl RNA, DNA, and phosphorothioate DNA. Antisense Nucleic Acid Drug Dev 1997; 7: 151-157.
    • (1997) Antisense Nucleic Acid Drug Dev , vol.7 , pp. 151-157
    • Stein, D.1    Foster, E.2    Huang, S.B.3    Weller, D.4    Summerton, J.5
  • 51
    • 0027390731 scopus 로고
    • Chemically modified RNA: Approaches and applications
    • Heidenreich O, Pieken W, Eckstein F. Chemically modified RNA: approaches and applications. FASEB J 1993; 7: 90-96.
    • (1993) FASEB J , vol.7 , pp. 90-96
    • Heidenreich, O.1    Pieken, W.2    Eckstein, F.3
  • 52
    • 0026337408 scopus 로고
    • Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes
    • Pieken WA, Olsen DB, Benseler F, Aurup H, Eckstein F. Kinetic characterization of ribonuclease-resistant 2′-modified hammerhead ribozymes. Science 1991; 253: 314-317.
    • (1991) Science , vol.253 , pp. 314-317
    • Pieken, W.A.1    Olsen, D.B.2    Benseler, F.3    Aurup, H.4    Eckstein, F.5
  • 53
    • 0030042588 scopus 로고    scopus 로고
    • Nuclease-resistant hammerhead ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint
    • Flory CM, Pavco PA, Jarvis TC, et al. Nuclease-resistant hammerhead ribozymes decrease stromelysin mRNA levels in rabbit synovium following exogenous delivery to the knee joint. Proc Natl Acad Sci USA 1996; 93: 754-758.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 754-758
    • Flory, C.M.1    Pavco, P.A.2    Jarvis, T.C.3
  • 54
    • 0033168947 scopus 로고    scopus 로고
    • Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA
    • Parry TJ, Cushman C, Gallegos AM, et al. Bioactivity of anti-angiogenic ribozymes targeting Flt-1 and KDR mRNA. Nucleic Acids Res 1999; 27: 2569-2577.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2569-2577
    • Parry, T.J.1    Cushman, C.2    Gallegos, A.M.3
  • 55
    • 0030968710 scopus 로고    scopus 로고
    • Mechanistic aspects of enzymatic catalysis: Lessons from the comparison of RNA and protein enzymes
    • Narlikar GJ, Herschlag D. Mechanistic aspects of enzymatic catalysis: lessons from the comparison of RNA and protein enzymes. Annu Rev Biochem 1997; 66: 19-59.
    • (1997) Annu Rev Biochem , vol.66 , pp. 19-59
    • Narlikar, G.J.1    Herschlag, D.2
  • 56
    • 0030996755 scopus 로고    scopus 로고
    • The new world of ribozymes
    • Jaeger L. The new world of ribozymes. Curr Opin Struct Biol 1997; 7: 324-335.
    • (1997) Curr Opin Struct Biol , vol.7 , pp. 324-335
    • Jaeger, L.1
  • 57
    • 0032552962 scopus 로고    scopus 로고
    • A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations
    • Peracchi A, Karpeisky A, Maloney L, Beigelman L, Herschlag D. A core folding model for catalysis by the hammerhead ribozyme accounts for its extraordinary sensitivity to abasic mutations. Biochemistry 1998; 37: 14765-14775.
    • (1998) Biochemistry , vol.37 , pp. 14765-14775
    • Peracchi, A.1    Karpeisky, A.2    Maloney, L.3    Beigelman, L.4    Herschlag, D.5
  • 58
    • 0035425380 scopus 로고    scopus 로고
    • Enzyme catalysis: Removing chemically 'essential' residues by site-directed mutagenesis
    • Peracchi A. Enzyme catalysis: removing chemically 'essential' residues by site-directed mutagenesis. Trends Biochem Sci 2001; 28: 497-503.
    • (2001) Trends Biochem Sci , vol.28 , pp. 497-503
    • Peracchi, A.1
  • 59
    • 0034635350 scopus 로고    scopus 로고
    • Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure?
    • Murray JB, Scott WG. Does a single metal ion bridge the A-9 and scissile phosphate groups in the catalytically active hammerhead ribozyme structure? J Mol Biol 2000; 296: 33-41.
    • (2000) J Mol Biol , vol.296 , pp. 33-41
    • Murray, J.B.1    Scott, W.G.2
  • 61
    • 0043009734 scopus 로고    scopus 로고
    • Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity
    • Khvorova A, Lescoute A, Westhof E, Jayasena SD. Sequence elements outside the hammerhead ribozyme catalytic core enable intracellular activity. Nat Struct Biol 2003; 10: 708-712.
    • (2003) Nat Struct Biol , vol.10 , pp. 708-712
    • Khvorova, A.1    Lescoute, A.2    Westhof, E.3    Jayasena, S.D.4
  • 62
    • 0033565629 scopus 로고    scopus 로고
    • Origins of the temperature dependence of hammerhead ribozyme catalysis
    • Peracchi A. Origins of the temperature dependence of hammerhead ribozyme catalysis. Nucleic Acids Res 1999; 27: 2875-2882.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2875-2882
    • Peracchi, A.1
  • 63
    • 0033971409 scopus 로고    scopus 로고
    • Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats
    • Salmi P, Sproat BS, Ludwig J, et al. Dopamine D(2) receptor ribozyme inhibits quinpirole-induced stereotypy in rats. Eur J Pharmacol 2000; 388: R1-R2.
    • (2000) Eur J Pharmacol , vol.388
    • Salmi, P.1    Sproat, B.S.2    Ludwig, J.3
  • 64
    • 0036784791 scopus 로고    scopus 로고
    • Ribozyme to proliferating cell nuclear antigen to treat proliferative vitreoretinopathy
    • Mandava N, Blackburn P, Paul DB, et al. Ribozyme to proliferating cell nuclear antigen to treat proliferative vitreoretinopathy. Invest Ophthalmol Vis Sci 2002; 43: 3338-3348.
    • (2002) Invest Ophthalmol Vis Sci , vol.43 , pp. 3338-3348
    • Mandava, N.1    Blackburn, P.2    Paul, D.B.3
  • 66
    • 0030783123 scopus 로고    scopus 로고
    • Efficient transfer of synthetic ribozymes into cells using hemagglutinating virus of Japan (HVJ)-cationic liposomes. Application for ribozymes that target human T-cell leukemia virus type I Tat/Rex mRNA
    • Kitajima I, Hanyu N, Soejima Y, et al. Efficient transfer of synthetic ribozymes into cells using hemagglutinating virus of Japan (HVJ)-cationic liposomes. Application for ribozymes that target human T-cell leukemia virus type I Tat/Rex mRNA. J Biol Chem 1997; 272: 27099-27106.
    • (1997) J Biol Chem , vol.272 , pp. 27099-27106
    • Kitajima, I.1    Hanyu, N.2    Soejima, Y.3
  • 68
    • 0031864708 scopus 로고    scopus 로고
    • A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth
    • Sioud M, Sorensen DR. A nuclease-resistant protein kinase C alpha ribozyme blocks glioma cell growth. Nature Biotechnol 1998; 16: 556-561.
    • (1998) Nature Biotechnol , vol.16 , pp. 556-561
    • Sioud, M.1    Sorensen, D.R.2
  • 69
    • 0034327421 scopus 로고    scopus 로고
    • HIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: Site selection and inhibition in cell culture
    • Bramlage B, Luzi E, Eckstein F. HIV-1 LTR as a target for synthetic ribozyme-mediated inhibition of gene expression: site selection and inhibition in cell culture. Nucleic Acids Res 2000; 28: 4059-4067.
    • (2000) Nucleic Acids Res , vol.28 , pp. 4059-4067
    • Bramlage, B.1    Luzi, E.2    Eckstein, F.3
  • 70
    • 0037600638 scopus 로고    scopus 로고
    • Peptide-mediated cellular delivery of anti-sense oligonucleotides and their analogues
    • Gait M. Peptide-mediated cellular delivery of anti-sense oligonucleotides and their analogues. Cell Mol Life Sci 2003; 60: 844-853.
    • (2003) Cell Mol Life Sci , vol.60 , pp. 844-853
    • Gait, M.1
  • 71
    • 0034882516 scopus 로고    scopus 로고
    • On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids
    • Hafez IM, Maurer N, Cullis PR. On the mechanism whereby cationic lipids promote intracellular delivery of polynucleic acids. Gene Ther 2001; 8: 1188-1196.
    • (2001) Gene Ther , vol.8 , pp. 1188-1196
    • Hafez, I.M.1    Maurer, N.2    Cullis, P.R.3
  • 72
    • 0036179935 scopus 로고    scopus 로고
    • Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments
    • Merdan T, Kunath K, Fischer D, Kopecek J, Kissel T. Intracellular processing of poly(ethylene imine)/ribozyme complexes can be observed in living cells by using confocal laser scanning microscopy and inhibitor experiments. Pharm Res 2002; 19: 140-146.
    • (2002) Pharm Res , vol.19 , pp. 140-146
    • Merdan, T.1    Kunath, K.2    Fischer, D.3    Kopecek, J.4    Kissel, T.5
  • 73
    • 0036953454 scopus 로고    scopus 로고
    • Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression
    • Aigner A, Fischer D, Merdan T, Brus C, Kissel T, Czubayko F. Delivery of unmodified bioactive ribozymes by an RNA-stabilizing polyethylenimine (LMW-PEI) efficiently down-regulates gene expression. Gene Ther 2002; 9: 1700-1707.
    • (2002) Gene Ther , vol.9 , pp. 1700-1707
    • Aigner, A.1    Fischer, D.2    Merdan, T.3    Brus, C.4    Kissel, T.5    Czubayko, F.6
  • 74
    • 12644252947 scopus 로고    scopus 로고
    • The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization
    • Bertrand E, Castanotto D, Zhou C, et al. The expression cassette determines the functional activity of ribozymes in mammalian cells by controlling their intracellular localization. RNA 1997; 1: 75-88.
    • (1997) RNA , vol.1 , pp. 75-88
    • Bertrand, E.1    Castanotto, D.2    Zhou, C.3
  • 75
    • 0000492933 scopus 로고    scopus 로고
    • mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymes
    • Lee NS, Bertrand E, Rossi J. mRNA localization signals can enhance the intracellular effectiveness of hammerhead ribozymes. RNA 1999; 5: 1200-1209.
    • (1999) RNA , vol.5 , pp. 1200-1209
    • Lee, N.S.1    Bertrand, E.2    Rossi, J.3
  • 76
    • 0034255512 scopus 로고    scopus 로고
    • Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA
    • Michienzi A, Cagnon L, Bahner I, Rossi JJ. Ribozyme-mediated inhibition of HIV 1 suggests nucleolar trafficking of HIV-1 RNA. Proc Natl Acad Sci USA 2000; 97: 8955-8960.
    • (2000) Proc Natl Acad Sci USA , vol.97 , pp. 8955-8960
    • Michienzi, A.1    Cagnon, L.2    Bahner, I.3    Rossi, J.J.4
  • 77
    • 0029856329 scopus 로고    scopus 로고
    • Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids
    • Zelphati O, Szoka FC, Jr. Intracellular distribution and mechanism of delivery of oligonucleotides mediated by cationic lipids. Pharm Res 1996; 13: 1367-1372.
    • (1996) Pharm Res , vol.13 , pp. 1367-1372
    • Zelphati, O.1    Szoka Jr., F.C.2
  • 78
    • 0033178274 scopus 로고    scopus 로고
    • Inhibition of luciferase expression by synthetic hammerhead ribozymes and their cellular uptake
    • Bramlage B, Alefelder S, Marschall P, Eckstein F. Inhibition of luciferase expression by synthetic hammerhead ribozymes and their cellular uptake. Nucleic Acids Res 1999; 27: 3159-3167.
    • (1999) Nucleic Acids Res , vol.27 , pp. 3159-3167
    • Bramlage, B.1    Alefelder, S.2    Marschall, P.3    Eckstein, F.4
  • 79
    • 0035805588 scopus 로고    scopus 로고
    • Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells
    • Kato Y, Kuwabara T, Warashina M, Toda H, Taira K. Relationships between the activities in vitro and in vivo of various kinds of ribozyme and their intracellular localization in mammalian cells. J Biol Chem 2001; 276: 15378-15385.
    • (2001) J Biol Chem , vol.276 , pp. 15378-15385
    • Kato, Y.1    Kuwabara, T.2    Warashina, M.3    Toda, H.4    Taira, K.5
  • 80
    • 85047695997 scopus 로고    scopus 로고
    • Purging of chronic myelogenous leukemia cells by retrovirally expressed anti-bcr-abl ribozymes with specific cellular compartmentalization
    • Mendoza-Maldonado R, Zentilin L, Fanin R, Giacca M. Purging of chronic myelogenous leukemia cells by retrovirally expressed anti-bcr-abl ribozymes with specific cellular compartmentalization. Cancer Gene Ther 2002; 9: 71-86.
    • (2002) Cancer Gene Ther , vol.9 , pp. 71-86
    • Mendoza-Maldonado, R.1    Zentilin, L.2    Fanin, R.3    Giacca, M.4
  • 81
    • 0031788404 scopus 로고    scopus 로고
    • Designing ribozymes for the inhibition of gene expression
    • Bramlage B, Luzi E, Eckstein F. Designing ribozymes for the inhibition of gene expression. Trends Biotechnol 1998; 16: 434-438.
    • (1998) Trends Biotechnol , vol.16 , pp. 434-438
    • Bramlage, B.1    Luzi, E.2    Eckstein, F.3
  • 83
    • 0034234550 scopus 로고    scopus 로고
    • RNA accessibility prediction: A theoretical approach is consistent with experimental studies in cell extracts
    • Scherr M, Rossi JJ, Sczakiel G, Patzel V. RNA accessibility prediction: a theoretical approach is consistent with experimental studies in cell extracts. Nucleic Acids Res 2000; 28: 2455-2461.
    • (2000) Nucleic Acids Res , vol.28 , pp. 2455-2461
    • Scherr, M.1    Rossi, J.J.2    Sczakiel, G.3    Patzel, V.4
  • 84
    • 0036399279 scopus 로고    scopus 로고
    • A method for prediction of accessible sites on an mRNA sequence for target selection of hammerhead ribozymes
    • Mercatanti A, Rainaldi G, Mariani L, Marangoni R, Citti L. A method for prediction of accessible sites on an mRNA sequence for target selection of hammerhead ribozymes. J Comput Biol 2002; 9: 641-653.
    • (2002) J Comput Biol , vol.9 , pp. 641-653
    • Mercatanti, A.1    Rainaldi, G.2    Mariani, L.3    Marangoni, R.4    Citti, L.5
  • 85
    • 0030952735 scopus 로고    scopus 로고
    • Probing accessible sites for ribozymes on human acetylcholinesterase RNA
    • Birikh KR, Berlin YA, Soreq H, Eckstein F. Probing accessible sites for ribozymes on human acetylcholinesterase RNA. RNA 1997; 3: 429-437.
    • (1997) RNA , vol.3 , pp. 429-437
    • Birikh, K.R.1    Berlin, Y.A.2    Soreq, H.3    Eckstein, F.4
  • 86
    • 0034223563 scopus 로고    scopus 로고
    • Oligonucleotide scanning of native mRNAs in extracts predicts intracellular ribozyme efficiency: Ribozyme-mediated reduction of the murine DNA methyltransferase
    • Scherr M, Reed M, Huang CF, Riggs AD, Rossi JJ. Oligonucleotide scanning of native mRNAs in extracts predicts intracellular ribozyme efficiency: ribozyme-mediated reduction of the murine DNA methyltransferase. Mol Ther 2000; 2: 26-38.
    • (2000) Mol Ther , vol.2 , pp. 26-38
    • Scherr, M.1    Reed, M.2    Huang, C.F.3    Riggs, A.D.4    Rossi, J.J.5
  • 87
    • 0035340552 scopus 로고    scopus 로고
    • Identifying ribozyme-accessible sites using NUH triplet-targeting gapmers
    • Mir AA, Lockett TJ, Hendry P. Identifying ribozyme-accessible sites using NUH triplet-targeting gapmers. Nucleic Acids Res 2001; 29: 1906-1914.
    • (2001) Nucleic Acids Res , vol.29 , pp. 1906-1914
    • Mir, A.A.1    Lockett, T.J.2    Hendry, P.3
  • 88
    • 0029163563 scopus 로고
    • RNA chaperones and the RNA folding problem
    • Herschlag D. RNA chaperones and the RNA folding problem. J Biol Chem 1995; 270: 20871-20874.
    • (1995) J Biol Chem , vol.270 , pp. 20871-20874
    • Herschlag, D.1
  • 89
    • 0035826734 scopus 로고    scopus 로고
    • RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA
    • Warashina M, Kuwabara T, Kato Y, Sano M, Taira K. RNA-protein hybrid ribozymes that efficiently cleave any mRNA independently of the structure of the target RNA. Proc Natl Acad Sci USA 2001; 98: 5572-5577.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 5572-5577
    • Warashina, M.1    Kuwabara, T.2    Kato, Y.3    Sano, M.4    Taira, K.5
  • 90
    • 0038352215 scopus 로고    scopus 로고
    • Engineered catalytic RNA and DNA: New biochemical tools for drug discovery and design
    • Steele D, Kertsburg A, Soukup GA. Engineered catalytic RNA and DNA: new biochemical tools for drug discovery and design. Am J Pharmacogenom 2003; 3: 131-144.
    • (2003) Am J Pharmacogenom , vol.3 , pp. 131-144
    • Steele, D.1    Kertsburg, A.2    Soukup, G.A.3
  • 91
    • 0033565475 scopus 로고    scopus 로고
    • Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization
    • Soukup GA, Breaker RR. Design of allosteric hammerhead ribozymes activated by ligand-induced structure stabilization. Structure Fold Des 1999; 7: 783-791.
    • (1999) Structure Fold Des , vol.7 , pp. 783-791
    • Soukup, G.A.1    Breaker, R.R.2
  • 92
    • 0036301260 scopus 로고    scopus 로고
    • A general strategy for effector-mediated control of RNA-cleaving ribozymes and DNA enzymes
    • Wang DY, Lai BH, Sen D. A general strategy for effector-mediated control of RNA-cleaving ribozymes and DNA enzymes. J Mol Biol 2002; 318: 33-43.
    • (2002) J Mol Biol , vol.318 , pp. 33-43
    • Wang, D.Y.1    Lai, B.H.2    Sen, D.3
  • 93
    • 0036022522 scopus 로고    scopus 로고
    • Monitoring post-translational modification of proteins with allosteric ribozymes
    • Vaish NK, Dong F, Andrews L, et al. Monitoring post-translational modification of proteins with allosteric ribozymes. Nat Biotechnol 2002; 20: 810-815.
    • (2002) Nat Biotechnol , vol.20 , pp. 810-815
    • Vaish, N.K.1    Dong, F.2    Andrews, L.3
  • 94
    • 0029859191 scopus 로고    scopus 로고
    • Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases
    • Peracchi A, Beigelman L, Usman N, Herschlag D. Rescue of abasic hammerhead ribozymes by exogenous addition of specific bases. Proc Natl Acad Sci USA 1996; 93: 11522-11527.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 11522-11527
    • Peracchi, A.1    Beigelman, L.2    Usman, N.3    Herschlag, D.4
  • 95
    • 0025850802 scopus 로고
    • Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: More isn't always better
    • Herschlag D. Implications of ribozyme kinetics for targeting the cleavage of specific RNA molecules in vivo: more isn't always better. Proc Natl Acad Sci USA 1991; 88: 6921-6925.
    • (1991) Proc Natl Acad Sci USA , vol.88 , pp. 6921-6925
    • Herschlag, D.1
  • 96
    • 0033551183 scopus 로고    scopus 로고
    • Hairpin ribozyme specificity in vivo: A case of promiscuous cleavage
    • Denman RB. Hairpin ribozyme specificity in vivo: a case of promiscuous cleavage. Biochem Biophys Res Commun 1999; 257: 356-360.
    • (1999) Biochem Biophys Res Commun , vol.257 , pp. 356-360
    • Denman, R.B.1
  • 97
    • 0029041941 scopus 로고
    • The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis
    • Werner M, Uhlenbeck OC. The effect of base mismatches in the substrate recognition helices of hammerhead ribozymes on binding and catalysis. Nucleic Acids Res 1995; 23: 2092-2096.
    • (1995) Nucleic Acids Res , vol.23 , pp. 2092-2096
    • Werner, M.1    Uhlenbeck, O.C.2
  • 98
    • 0029810775 scopus 로고    scopus 로고
    • Design of hammerhead ribozymes to distinguish single base changes in substrate RNA
    • Singh KK, Schluff P, Lehnert L, Krupp G. Design of hammerhead ribozymes to distinguish single base changes in substrate RNA. Antisense Nucleic Acid Drug Dev 1996; 6: 165-168.
    • (1996) Antisense Nucleic Acid Drug Dev , vol.6 , pp. 165-168
    • Singh, K.K.1    Schluff, P.2    Lehnert, L.3    Krupp, G.4
  • 99
    • 12644276403 scopus 로고    scopus 로고
    • Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections
    • Desjardins JP, Sproat BS, Beijer B, et al. Pharmacokinetics of a synthetic, chemically modified hammerhead ribozyme against the rat cytochrome P-450 3A2 mRNA after single intravenous injections. J Pharmacol Exp Ther 1996; 278: 1419-1427.
    • (1996) J Pharmacol Exp Ther , vol.278 , pp. 1419-1427
    • Desjardins, J.P.1    Sproat, B.S.2    Beijer, B.3
  • 100
    • 6744226349 scopus 로고    scopus 로고
    • Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targeting vascular endothelial growth factor receptor mRNA in the cynomolgus monkey
    • Sandberg JA, Sproul CD, Blanchard KS, et al. Acute toxicology and pharmacokinetic assessment of a ribozyme (ANGIOZYME) targeting vascular endothelial growth factor receptor mRNA in the cynomolgus monkey. Antisense Nucleic Acid Drug Dev 2000; 10: 153-162.
    • (2000) Antisense Nucleic Acid Drug Dev , vol.10 , pp. 153-162
    • Sandberg, J.A.1    Sproul, C.D.2    Blanchard, K.S.3
  • 101
    • 0032853334 scopus 로고    scopus 로고
    • Antisense oligonucleotides as therapeutic agents
    • Galderisi U, Cascino A, Giordano A. Antisense oligonucleotides as therapeutic agents. J Cell Physiol 1999; 181: 251-257.
    • (1999) J Cell Physiol , vol.181 , pp. 251-257
    • Galderisi, U.1    Cascino, A.2    Giordano, A.3
  • 102
  • 104
    • 0034671699 scopus 로고    scopus 로고
    • Making catalytic DNAs
    • Breaker RR. Making catalytic DNAs. Science 2000; 290: 2095-2096.
    • (2000) Science , vol.290 , pp. 2095-2096
    • Breaker, R.R.1
  • 105
    • 0028983570 scopus 로고
    • 2+-dependent RNA phosphoesterase activity
    • 2+-dependent RNA phosphoesterase activity. Chem Biol 1995; 2: 655-660.
    • (1995) Chem Biol , vol.2 , pp. 655-660
    • Breaker, R.R.1    Joyce, G.F.2
  • 106
    • 0030898510 scopus 로고    scopus 로고
    • A general purpose RNA-cleaving DNA enzyme
    • Santoro SW, Joyce GF. A general purpose RNA-cleaving DNA enzyme. Proc Natl Acad Sci USA 1997; 94: 4262-4266.
    • (1997) Proc Natl Acad Sci USA , vol.94 , pp. 4262-4266
    • Santoro, S.W.1    Joyce, G.F.2
  • 107
    • 0030498356 scopus 로고    scopus 로고
    • 2+ ion as a cofactor for a novel RNA-cleaving deoxyribozyme
    • 2+ ion as a cofactor for a novel RNA-cleaving deoxyribozyme. Angew Chem Int Ed Engl 1996; 35: 2837-2841.
    • (1996) Angew Chem Int Ed Engl , vol.35 , pp. 2837-2841
    • Faulhammer, D.1    Famulok, M.2
  • 108
    • 0034697291 scopus 로고    scopus 로고
    • + ions. Evidence for the identity of 8-17 with the catalytic domain of the Mg5 deoxyribozyme
    • + ions. Evidence for the identity of 8-17 with the catalytic domain of the Mg5 deoxyribozyme. J Biol Chem 2000; 275: 11693-11697.
    • (2000) J Biol Chem , vol.275 , pp. 11693-11697
    • Peracchi, A.1
  • 109
    • 0034650291 scopus 로고    scopus 로고
    • In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme
    • Li J, Zheng W, Kwon AH, Lu Y. In vitro selection and characterization of a highly efficient Zn(II)-dependent RNA-cleaving deoxyribozyme. Nucleic Acids Res 2000; 28: 481-488.
    • (2000) Nucleic Acids Res , vol.28 , pp. 481-488
    • Li, J.1    Zheng, W.2    Kwon, A.H.3    Lu, Y.4
  • 110
    • 0031215119 scopus 로고    scopus 로고
    • Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme
    • Geyer CR, Sen D. Evidence for the metal-cofactor independence of an RNA phosphodiester-cleaving DNA enzyme. Chem Biol 1997; 4: 579-593.
    • (1997) Chem Biol , vol.4 , pp. 579-593
    • Geyer, C.R.1    Sen, D.2
  • 111
    • 0035914482 scopus 로고    scopus 로고
    • A new and efficient DNA enzyme for the sequence-specific cleavage of RNA
    • Feldman AR, Sen D. A new and efficient DNA enzyme for the sequence-specific cleavage of RNA. J Mol Biol 2001; 313: 283-294.
    • (2001) J Mol Biol , vol.313 , pp. 283-294
    • Feldman, A.R.1    Sen, D.2
  • 112
    • 0037870470 scopus 로고    scopus 로고
    • Assemblage of signaling DNA enzymes with intriguing metal-ion specificities and pH dependences
    • Liu Z, Mei SH, Brennan JD, Li Y. Assemblage of signaling DNA enzymes with intriguing metal-ion specificities and pH dependences. J Am Chem Soc 2003; 125: 7539-7545.
    • (2003) J Am Chem Soc , vol.125 , pp. 7539-7545
    • Liu, Z.1    Mei, S.H.2    Brennan, J.D.3    Li, Y.4
  • 113
    • 0034711950 scopus 로고    scopus 로고
    • Design of nuclease resistant protein kinase ca DNA enzymes with potential therapeutic application
    • Sioud M, Leirdal M. Design of nuclease resistant protein kinase ca DNA enzymes with potential therapeutic application. J Mol Biol 2000; 296: 937-947.
    • (2000) J Mol Biol , vol.296 , pp. 937-947
    • Sioud, M.1    Leirdal, M.2
  • 115
    • 0033117651 scopus 로고    scopus 로고
    • Extremely high and specific activity of DNA enzymes in cells with a Philadelphia chromosome
    • Warashina M, Kuwabara T, Nakamatsu Y, Taira K. Extremely high and specific activity of DNA enzymes in cells with a Philadelphia chromosome. Chem Biol 1999; 6: 237-250.
    • (1999) Chem Biol , vol.6 , pp. 237-250
    • Warashina, M.1    Kuwabara, T.2    Nakamatsu, Y.3    Taira, K.4
  • 116
    • 0032865553 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus-directed gene expression by a DNA ribonuclease
    • Oketani M, Asahina Y, Wu CH, Wu GY. Inhibition of hepatitis C virus-directed gene expression by a DNA ribonuclease. J Hepatol 1999; 31: 628-634.
    • (1999) J Hepatol , vol.31 , pp. 628-634
    • Oketani, M.1    Asahina, Y.2    Wu, C.H.3    Wu, G.Y.4
  • 117
    • 0037145999 scopus 로고    scopus 로고
    • LNAzymes: Incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage
    • Vester B, Lundberg LB, Sorensen MD, Babu BR, Douthwaite S, Wengel J. LNAzymes: incorporation of LNA-type monomers into DNAzymes markedly increases RNA cleavage. J Am Chem Soc 2002; 124: 13682-13683.
    • (2002) J Am Chem Soc , vol.124 , pp. 13682-13683
    • Vester, B.1    Lundberg, L.B.2    Sorensen, M.D.3    Babu, B.R.4    Douthwaite, S.5    Wengel, J.6
  • 118
    • 0037175009 scopus 로고    scopus 로고
    • Sequence requirements in the catalytic core of the '10-23' DNA enzyme
    • Zaborowska Z, Furste JP, Erdmann VA, Kurreck J. Sequence requirements in the catalytic core of the '10-23' DNA enzyme. J Biol Chem 2002; 277: 40617-40622.
    • (2002) J Biol Chem , vol.277 , pp. 40617-40622
    • Zaborowska, Z.1    Furste, J.P.2    Erdmann, V.A.3    Kurreck, J.4
  • 119
    • 0032558463 scopus 로고    scopus 로고
    • Mechanism and utility of an RNA-cleaving DNA enzyme
    • Santoro SW, Joyce GF. Mechanism and utility of an RNA-cleaving DNA enzyme. Biochemistry 1998; 37: 13330-13342.
    • (1998) Biochemistry , vol.37 , pp. 13330-13342
    • Santoro, S.W.1    Joyce, G.F.2
  • 120
    • 0036510780 scopus 로고    scopus 로고
    • Comparative study of DNA enzymes and ribozymes against the same full-length messenger RNA of the vanilloid receptor subtype I
    • Kurreck J, Bieber B, Jahnel R, Erdmann VA. Comparative study of DNA enzymes and ribozymes against the same full-length messenger RNA of the vanilloid receptor subtype I. J Biol Chem 2002; 277: 7099-7107.
    • (2002) J Biol Chem , vol.277 , pp. 7099-7107
    • Kurreck, J.1    Bieber, B.2    Jahnel, R.3    Erdmann, V.A.4
  • 121
    • 0030759207 scopus 로고    scopus 로고
    • Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to cleavage of BCR-ABL chimeric L6 (b2a2) mRNA
    • Kuwabara T, Warashina M, Tanabe T, Tani K, Asano S, Taira K. Comparison of the specificities and catalytic activities of hammerhead ribozymes and DNA enzymes with respect to cleavage of BCR-ABL chimeric L6 (b2a2) mRNA. Nucleic Acids Res 1997; 25: 3074-3081.
    • (1997) Nucleic Acids Res , vol.25 , pp. 3074-3081
    • Kuwabara, T.1    Warashina, M.2    Tanabe, T.3    Tani, K.4    Asano, S.5    Taira, K.6
  • 122
    • 0037503751 scopus 로고    scopus 로고
    • Identification of cleavage sites in the HIV-1 TAR RNA by 10-23 and 8-17 catalytic motif containing DNA enzymes
    • Chakraborti S, Banerjea AC. Identification of cleavage sites in the HIV-1 TAR RNA by 10-23 and 8-17 catalytic motif containing DNA enzymes. Biomacromolecules 2003; 4: 568-571.
    • (2003) Biomacromolecules , vol.4 , pp. 568-571
    • Chakraborti, S.1    Banerjea, A.C.2
  • 123
    • 0033546334 scopus 로고    scopus 로고
    • Suppression of smooth muscle cell proliferation by a c-myc RNA-cleaving deoxyribozyme
    • Sun LQ, Cairns MJ, Gerlach WL, Witherington C, Wang L, King A. Suppression of smooth muscle cell proliferation by a c-myc RNA-cleaving deoxyribozyme. J Biol Chem 1999; 274: 17236-17241.
    • (1999) J Biol Chem , vol.274 , pp. 17236-17241
    • Sun, L.Q.1    Cairns, M.J.2    Gerlach, W.L.3    Witherington, C.4    Wang, L.5    King, A.6
  • 124
    • 0034666079 scopus 로고    scopus 로고
    • Inhibition of influenza virus replication in cultured cells by RNA-cleaving DNA enzyme
    • Toyoda T, Imamura Y, Takaku H, et al. Inhibition of influenza virus replication in cultured cells by RNA-cleaving DNA enzyme. FEBS Lett 2000; 481: 113-116.
    • (2000) FEBS Lett , vol.481 , pp. 113-116
    • Toyoda, T.1    Imamura, Y.2    Takaku, H.3
  • 125
    • 0035253125 scopus 로고    scopus 로고
    • Inhibition of hepatitis B virus X gene expression by novel DNA enzymes
    • Goila R, Banerjea AC. Inhibition of hepatitis B virus X gene expression by novel DNA enzymes. Biochem J 2001; 353: 701-708.
    • (2001) Biochem J , vol.353 , pp. 701-708
    • Goila, R.1    Banerjea, A.C.2
  • 126
    • 0032717640 scopus 로고    scopus 로고
    • New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury
    • Santiago FS, Lowe HC, Kavurma MM, et al. New DNA enzyme targeting Egr-1 mRNA inhibits vascular smooth muscle proliferation and regrowth after injury. Nature Med 1999; 5: 1264-1269.
    • (1999) Nature Med , vol.5 , pp. 1264-1269
    • Santiago, F.S.1    Lowe, H.C.2    Kavurma, M.M.3
  • 127
    • 0036858411 scopus 로고    scopus 로고
    • Combination of endostatin and a protein kinase C-a DNA enzyme improves the survival of rats with malignant glioma
    • Sorensen DR, Leirdal M, Iversen PO, Sioud M. Combination of endostatin and a protein kinase C-a DNA enzyme improves the survival of rats with malignant glioma. Neoplasia 2002; 4: 474-479.
    • (2002) Neoplasia , vol.4 , pp. 474-479
    • Sorensen, D.R.1    Leirdal, M.2    Iversen, P.O.3    Sioud, M.4
  • 128
    • 0346850835 scopus 로고    scopus 로고
    • Structural rearrangements of the '10-23' DNA-zyme to beta 3 integrin subunit mRNA induced by cations and their relations to the catalytic activity
    • Cieslak M, Szymanski J, Adamiak R, Cierniewski CS. Structural rearrangements of the '10-23' DNA-zyme to beta 3 integrin subunit mRNA induced by cations and their relations to the catalytic activity. J Biol Chem 2003; 278: 47987-47996.
    • (2003) J Biol Chem , vol.278 , pp. 47987-47996
    • Cieslak, M.1    Szymanski, J.2    Adamiak, R.3    Cierniewski, C.S.4
  • 129
    • 0026055747 scopus 로고
    • + lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme
    • + lymphocyte-derived cell lines conferred by using retroviral vectors expressing an HIV-1 RNA-specific ribozyme. J Virol 1991; 65: 5531-5534.
    • (1991) J Virol , vol.65 , pp. 5531-5534
    • Weerasinghe, M.1    Liem, S.E.2    Asad, S.3    Read, S.E.4    Joshi, S.5
  • 130
    • 0026785305 scopus 로고
    • Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA
    • Lo KM, Biasolo MA, Dehni G, Palu G, Haseltine WA. Inhibition of replication of HIV-1 by retroviral vectors expressing tat-antisense and anti-tat ribozyme RNA. Virology 1992; 190: 176-183.
    • (1992) Virology , vol.190 , pp. 176-183
    • Lo, K.M.1    Biasolo, M.A.2    Dehni, G.3    Palu, G.4    Haseltine, W.A.5
  • 132
    • 0030006085 scopus 로고    scopus 로고
    • U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus
    • Michienzi A, Prislei S, Bozzoni I. U1 small nuclear RNA chimeric ribozymes with substrate specificity for the Rev pre-mRNA of human immunodeficiency virus. Proc Natl Acad Sci USA 1996; 93: 7219-7224.
    • (1996) Proc Natl Acad Sci USA , vol.93 , pp. 7219-7224
    • Michienzi, A.1    Prislei, S.2    Bozzoni, I.3
  • 133
    • 0033514517 scopus 로고    scopus 로고
    • tRNAVal-heterodimeric maxizymes with high potential as gene-inactivating agents: Simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells
    • Kuwabara T, Warashina M, Nakayama A, Ohkawa J, Taira K. tRNAVal-heterodimeric maxizymes with high potential as gene-inactivating agents: simultaneous cleavage at two sites in HIV-1 Tat mRNA in cultured cells. Proc Natl Acad Sci USA 1999; 96: 1886-1891.
    • (1999) Proc Natl Acad Sci USA , vol.96 , pp. 1886-1891
    • Kuwabara, T.1    Warashina, M.2    Nakayama, A.3    Ohkawa, J.4    Taira, K.5
  • 134
    • 0034652541 scopus 로고    scopus 로고
    • Intravirion targeting of a functional anti-human immunodeficiency virus ribozyme directed to pol
    • Giordano V, Jin DY, Rekosh D, Jeang KT. Intravirion targeting of a functional anti-human immunodeficiency virus ribozyme directed to pol. Virology 2000; 267: 174-184.
    • (2000) Virology , vol.267 , pp. 174-184
    • Giordano, V.1    Jin, D.Y.2    Rekosh, D.3    Jeang, K.T.4
  • 135
    • 0038684577 scopus 로고    scopus 로고
    • Inhibition of HIV-1 replication by an HIV-1 dependent ribozyme expression vector with the Cre/loxP (ON/OFF) system
    • Habu Y, Miyano-Kurosaki N, Nagawa T, Matsumoto N, Takeuchi H, Takaku H. Inhibition of HIV-1 replication by an HIV-1 dependent ribozyme expression vector with the Cre/loxP (ON/OFF) system. Antivir Chem Chemother 2002; 13: 273-281.
    • (2002) Antivir Chem Chemother , vol.13 , pp. 273-281
    • Habu, Y.1    Miyano-Kurosaki, N.2    Nagawa, T.3    Matsumoto, N.4    Takeuchi, H.5    Takaku, H.6
  • 136
    • 0035997931 scopus 로고    scopus 로고
    • Additive and antagonist effects of therapeutic gene combinations for suppression of HIV-1 infection
    • Gennari F, Biasolo MA, Cancellotti E, et al. Additive and antagonist effects of therapeutic gene combinations for suppression of HIV-1 infection. Antiviral Res 2002; 55: 77-90.
    • (2002) Antiviral Res , vol.55 , pp. 77-90
    • Gennari, F.1    Biasolo, M.A.2    Cancellotti, E.3
  • 137
    • 0036479428 scopus 로고    scopus 로고
    • Development and testing of retroviral vectors expressing multimeric hammerhead ribozymes targeted against all major clades of HIV-1
    • Ramezani A, Ma XZ, Nazari R, Joshi S. Development and testing of retroviral vectors expressing multimeric hammerhead ribozymes targeted against all major clades of HIV-1. Front Biosci 2002; 7: a29-36.
    • (2002) Front Biosci , vol.7
    • Ramezani, A.1    Ma, X.Z.2    Nazari, R.3    Joshi, S.4
  • 138
    • 0032211255 scopus 로고    scopus 로고
    • A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA
    • Wong-Staal F, Poeschla EM, Looney DJ. A controlled, Phase 1 clinical trial to evaluate the safety and effects in HIV-1 infected humans of autologous lymphocytes transduced with a ribozyme that cleaves HIV-1 RNA. Hum Gene Ther 1998; 9: 2407-2425.
    • (1998) Hum Gene Ther , vol.9 , pp. 2407-2425
    • Wong-Staal, F.1    Poeschla, E.M.2    Looney, D.J.3
  • 139
    • 0033198914 scopus 로고    scopus 로고
    • + hematopoietic progenitor cells transduced with an anti-HIV ribozyme
    • + hematopoietic progenitor cells transduced with an anti-HIV ribozyme. Hum Gene Ther 1999; 10: 2255-2270.
    • (1999) Hum Gene Ther , vol.10 , pp. 2255-2270
    • Amado, R.G.1    Mitsuyasu, R.T.2    Symonds, G.3
  • 140
    • 0032563328 scopus 로고    scopus 로고
    • Targeted cleavage of HIV-1 envelope gene by a DNA enzyme and inhibition of HIV-1 envelope-CD4 mediated cell fusion
    • Dash BC, Harikrishnan TA, Goila R, et al. Targeted cleavage of HIV-1 envelope gene by a DNA enzyme and inhibition of HIV-1 envelope-CD4 mediated cell fusion. FEBS Lett 1998; 431: 395-399.
    • (1998) FEBS Lett , vol.431 , pp. 395-399
    • Dash, B.C.1    Harikrishnan, T.A.2    Goila, R.3
  • 141
    • 0032426151 scopus 로고    scopus 로고
    • Phosphorothioate hammerhead ribozymes targeting a conserved sequence in the V3 loop region inhibit HIV-1 entry
    • Zhang X, Iwatani Y, Shimayama T, et al. Phosphorothioate hammerhead ribozymes targeting a conserved sequence in the V3 loop region inhibit HIV-1 entry. Antisense Nucleic Acid Drug Dev 1998; 8: 441-450.
    • (1998) Antisense Nucleic Acid Drug Dev , vol.8 , pp. 441-450
    • Zhang, X.1    Iwatani, Y.2    Shimayama, T.3
  • 142
    • 0032821352 scopus 로고    scopus 로고
    • Inhibition of infection of incoming HIV-1 virus by RNA-cleaving DNA enzyme
    • Zhang X, Xu Y, Ling H, Hattori T. Inhibition of infection of incoming HIV-1 virus by RNA-cleaving DNA enzyme. FEBS Lett 1999; 458: 151-156.
    • (1999) FEBS Lett , vol.458 , pp. 151-156
    • Zhang, X.1    Xu, Y.2    Ling, H.3    Hattori, T.4
  • 143
    • 0034672352 scopus 로고    scopus 로고
    • In vitro-selected RNA cleaving DNA enzymes from a combinatorial library are potent inhibitors of HIV-1 gene expression
    • Sriram B, Banerjea AC. In vitro-selected RNA cleaving DNA enzymes from a combinatorial library are potent inhibitors of HIV-1 gene expression. Biochem J 2000; 352: 667-673.
    • (2000) Biochem J , vol.352 , pp. 667-673
    • Sriram, B.1    Banerjea, A.C.2
  • 144
    • 0035396577 scopus 로고    scopus 로고
    • Inhibition of HIV-1 gene expression by novel macrophage-tropic DNA enzymes targeted to cleave HIV-1 TAT/Rev RNA
    • Unwalla H, Banerjea AC. Inhibition of HIV-1 gene expression by novel macrophage-tropic DNA enzymes targeted to cleave HIV-1 TAT/Rev RNA. Biochem J 2001; 357: 147-155.
    • (2001) Biochem J , vol.357 , pp. 147-155
    • Unwalla, H.1    Banerjea, A.C.2
  • 145
    • 0034954516 scopus 로고    scopus 로고
    • Novel mono- and di-DNA-enzymes targeted to cleave TAT or TAT-REV RNA inhibit HIV-1 gene expression
    • Unwalla H, Banerjea AC. Novel mono- and di-DNA-enzymes targeted to cleave TAT or TAT-REV RNA inhibit HIV-1 gene expression. Antiviral Res 2001; 51: 127-139.
    • (2001) Antiviral Res , vol.51 , pp. 127-139
    • Unwalla, H.1    Banerjea, A.C.2
  • 146
    • 0038489114 scopus 로고    scopus 로고
    • Inhibition of HIV-1 gene expression by novel DNA enzymes targeted to cleave HIV-1 TAR RNA: Potential effectiveness against all HIV-1 isolates
    • Chakraborti S, Banerjea AC. Inhibition of HIV-1 gene expression by novel DNA enzymes targeted to cleave HIV-1 TAR RNA: potential effectiveness against all HIV-1 isolates. Mol Ther 2003; 7: 817-826.
    • (2003) Mol Ther , vol.7 , pp. 817-826
    • Chakraborti, S.1    Banerjea, A.C.2
  • 147
    • 0037979127 scopus 로고    scopus 로고
    • Chronic hepatitis C virus infection
    • Flamm SL. Chronic hepatitis C virus infection. JAMA 2003; 289: 2413-2417.
    • (2003) JAMA , vol.289 , pp. 2413-2417
    • Flamm, S.L.1
  • 148
    • 0026728652 scopus 로고
    • Sequence analysis of the 5′ noncoding region of hepatitis C virus
    • Bukh J, Purcell RH, Miller RH. Sequence analysis of the 5′ noncoding region of hepatitis C virus. Proc Natl Acad Sci USA 1992; 89: 4942-4946.
    • (1992) Proc Natl Acad Sci USA , vol.89 , pp. 4942-4946
    • Bukh, J.1    Purcell, R.H.2    Miller, R.H.3
  • 149
    • 0029972264 scopus 로고    scopus 로고
    • A potential therapeutic application of hairpin ribozymes: In vitro and in vivo studies of gene therapy for hepatitis C virus infection
    • Welch PJ, Tritz R, Yei S, Leavitt M, Yu M, Barber J. A potential therapeutic application of hairpin ribozymes: in vitro and in vivo studies of gene therapy for hepatitis C virus infection. Gene Ther 1996; 3: 994-1001.
    • (1996) Gene Ther , vol.3 , pp. 994-1001
    • Welch, P.J.1    Tritz, R.2    Yei, S.3    Leavitt, M.4    Yu, M.5    Barber, J.6
  • 150
    • 0032527497 scopus 로고    scopus 로고
    • Ribozyme gene therapy for hepatitis C virus infection
    • Welch PJ, Yei S, Barber JR. Ribozyme gene therapy for hepatitis C virus infection. Clin Diagn Virol 1998; 10: 163-171.
    • (1998) Clin Diagn Virol , vol.10 , pp. 163-171
    • Welch, P.J.1    Yei, S.2    Barber, J.R.3
  • 151
    • 0030481468 scopus 로고    scopus 로고
    • Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes
    • Sakamoto N, Wu CH, Wu GY. Intracellular cleavage of hepatitis C virus RNA and inhibition of viral protein translation by hammerhead ribozymes. J Clin Invest 1996; 98: 2720-2728.
    • (1996) J Clin Invest , vol.98 , pp. 2720-2728
    • Sakamoto, N.1    Wu, C.H.2    Wu, G.Y.3
  • 152
    • 17544378561 scopus 로고    scopus 로고
    • Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV polio-virus using synthetic stabilized ribozymes
    • Macejak DG, Jensen KL, Jamison SF, et al. Inhibition of hepatitis C virus (HCV)-RNA-dependent translation and replication of a chimeric HCV polio-virus using synthetic stabilized ribozymes. Hepatology 2000; 31: 769-776.
    • (2000) Hepatology , vol.31 , pp. 769-776
    • Macejak, D.G.1    Jensen, K.L.2    Jamison, S.F.3
  • 153
    • 1642560293 scopus 로고    scopus 로고
    • 10 September
    • Ribozyme Pharmaceuticals Inc. website. http://www.rpi.com/clin1.jsp. [10 September 2003].
    • (2003)
  • 154
  • 155
    • 0029959522 scopus 로고    scopus 로고
    • Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA
    • Jarvis TC, Alby LJ, Beaudry AA, et al. Inhibition of vascular smooth muscle cell proliferation by ribozymes that cleave c-myb mRNA. RNA 1996; 2: 419-428.
    • (1996) RNA , vol.2 , pp. 419-428
    • Jarvis, T.C.1    Alby, L.J.2    Beaudry, A.A.3
  • 156
    • 0031686224 scopus 로고    scopus 로고
    • Synthetic 2′-O-methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity
    • Wan MS, Fell PL, Akhtar S. Synthetic 2′-O-methyl-modified hammerhead ribozymes targeted to the RNA component of telomerase as sequence-specific inhibitors of telomerase activity. Antisense Nucleic Acid Drug Dev 1998; 8: 309-317.
    • (1998) Antisense Nucleic Acid Drug Dev , vol.8 , pp. 309-317
    • Wan, M.S.1    Fell, P.L.2    Akhtar, S.3
  • 157
    • 0033168564 scopus 로고    scopus 로고
    • Enzymatic and antisense effects of a specific anti-Ki-ras ribozyme in vitro and in cell culture
    • Giannini CD, Roth WK, Piiper A, Zeuzem S. Enzymatic and antisense effects of a specific anti-Ki-ras ribozyme in vitro and in cell culture. Nucleic Acids Res 1999; 27: 2737-2744.
    • (1999) Nucleic Acids Res , vol.27 , pp. 2737-2744
    • Giannini, C.D.1    Roth, W.K.2    Piiper, A.3    Zeuzem, S.4
  • 159
    • 0035859929 scopus 로고    scopus 로고
    • Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems
    • Caplen NJ, Parrish S, Imani F, Fire A, Morgan RA. Specific inhibition of gene expression by small double-stranded RNAs in invertebrate and vertebrate systems. Proc Natl Acad Sci USA 2001; 98: 9742-9747.
    • (2001) Proc Natl Acad Sci USA , vol.98 , pp. 9742-9747
    • Caplen, N.J.1    Parrish, S.2    Imani, F.3    Fire, A.4    Morgan, R.A.5
  • 160
    • 0035942736 scopus 로고    scopus 로고
    • Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells
    • Elbashir SM, Harborth J, Lendeckel W, Yalcin A, Weber K, Tuschl T. Duplexes of 21-nucleotide RNAs mediate RNA interference in cultured mammalian cells. Nature 2001; 411: 494-498.
    • (2001) Nature , vol.411 , pp. 494-498
    • Elbashir, S.M.1    Harborth, J.2    Lendeckel, W.3    Yalcin, A.4    Weber, K.5    Tuschl, T.6
  • 161
    • 24144445346 scopus 로고    scopus 로고
    • Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells
    • Miyagishi M, Hayashi M, Taira K. Comparison of the suppressive effects of antisense oligonucleotides and siRNAs directed against the same targets in mammalian cells. Antisense Nucleic Acid Drug Dev 2003; 13: 1-7.
    • (2003) Antisense Nucleic Acid Drug Dev , vol.13 , pp. 1-7
    • Miyagishi, M.1    Hayashi, M.2    Taira, K.3
  • 162
    • 0042161890 scopus 로고    scopus 로고
    • The activity of siRNA in mammalian cells is related to structural target accessibility: A comparison with antisense oligonucleotides
    • Kretschmer-Kazemi Far R, Sczakiel G. The activity of siRNA in mammalian cells is related to structural target accessibility: a comparison with antisense oligonucleotides. Nucleic Acids Res 2003; 31: 4417-4424.
    • (2003) Nucleic Acids Res , vol.31 , pp. 4417-4424
    • Kretschmer-Kazemi Far, R.1    Sczakiel, G.2
  • 164
    • 0037470145 scopus 로고    scopus 로고
    • Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis
    • Vickers TA, Koo S, Bennett CF, Crooke ST, Dean NM, Baker BF. Efficient reduction of target RNAs by small interfering RNA and RNase H-dependent antisense agents. A comparative analysis. J Biol Chem 2003; 278: 7108-7118.
    • (2003) J Biol Chem , vol.278 , pp. 7108-7118
    • Vickers, T.A.1    Koo, S.2    Bennett, C.F.3    Crooke, S.T.4    Dean, N.M.5    Baker, B.F.6
  • 165
    • 0038578021 scopus 로고    scopus 로고
    • Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA
    • Grunweller A, Wyszko E, Bieber B, Jahnel R, Erdmann VA, Kurreck J. Comparison of different antisense strategies in mammalian cells using locked nucleic acids, 2′-O-methyl RNA, phosphorothioates and small interfering RNA. Nucleic Acids Res 2003; 31: 3185-3193.
    • (2003) Nucleic Acids Res , vol.31 , pp. 3185-3193
    • Grunweller, A.1    Wyszko, E.2    Bieber, B.3    Jahnel, R.4    Erdmann, V.A.5    Kurreck, J.6
  • 166
    • 0036696519 scopus 로고    scopus 로고
    • Comparative analysis of antisense RNA, double-stranded RNA, and delta ribozyme-mediated gene regulation in Toxoplasma gondii
    • Al-Anouti F, Ananvoranich S. Comparative analysis of antisense RNA, double-stranded RNA, and delta ribozyme-mediated gene regulation in Toxoplasma gondii. Antisense Nucleic Acid Drug Dev 2002; 12: 275-281.
    • (2002) Antisense Nucleic Acid Drug Dev , vol.12 , pp. 275-281
    • Al-Anouti, F.1    Ananvoranich, S.2
  • 168
    • 0037733977 scopus 로고    scopus 로고
    • Antisense technologies. Improvement through novel chemical modifications
    • Kurreck J. Antisense technologies. Improvement through novel chemical modifications. Eur J Biochem 2003; 270: 1628-1644.
    • (2003) Eur J Biochem , vol.270 , pp. 1628-1644
    • Kurreck, J.1


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