Bile acid amides derived from chiral amino alcohols: Novel antimicrobials and antifungals

Bioorganic and Medicinal Chemistry Letters

Volumn 14, Issue 3, 2004, Pages 773-777

  Hazra, Braja G ^a   Pore, Vandana S ^a   Dey, Sanjeev Kumar ^a,c   Datta, Suchitra ^a,c   Darokar, Mahendra P ^b   Saikia, Dharmendra ^b   Khanuja, S P S ^b   Thakur, Anup P ^a  

^a NATIONAL CHEMICAL LABORATORY   (India)

^b CSIR CENTRAL INSTITUTE OF MEDICINAL AND AROMATIC PLANTS   (India)

^c INDIAN INSTITUTE OF TECHNOLOGY   (India)

Author keywords

[No Author keywords available]

Indexed keywords

1 (4 NITROPHENYL) 2 CHOLIC ACETAMIDOPROPANE 1,3 DIOL; 1 (4 NITROPHENYL) 2 DEOXYCHOLIC ACETAMIDOPROPANE 1,3 DIOL; 1 PHENYL 2 AMINO 1,3 PROPANEDIOL; 1 PHENYL 2 CHOLIC ACETAMIDOPROPANE 1,3 DIOL; 1 PHENYL 2 DEOXYCHOLIC ACETAMIDOPROPANE 1,3 DIOL; 1,3 PROPANEDIOL; 2 AMINO 1 (4 NITROPHENYL) 1,3 PROPANEDIOL; AMIDE; AMINOALCOHOL; ANTIFUNGAL AGENT; ANTIINFECTIVE AGENT; BILE ACID; CHOLIC ACID; DEOXYCHOLIC ACID; SUCCINIMIDE DERIVATIVE; UNCLASSIFIED DRUG;

ANTIFUNGAL ACTIVITY; ANTIMICROBIAL ACTIVITY; ARTICLE; CRYPTOCOCCUS NEOFORMANS; DRUG POTENCY; DRUG SYNTHESIS; GRAM POSITIVE BACTERIUM; NONHUMAN;

FILOBASIDIELLA NEOFORMANS; POSIBACTERIA;

EID: 1642452632     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2003.11.018     Document Type: Article

References (19)

1. Savage P.B. Eur. J. Org. Chem. 2002;759.
2. Savage P.B., Li C. Exp. Opin. Invest. Drugs. 9:2000;263.
3. Sadownik A., Deng G., Janout V., Regen S.L. J. Am. Chem. Soc. 117:1995;6138.
4. Boyce R., Li G., Nestler H.P., Suenaga T., Still W.C. J. Am. Chem. Soc. 116:1994;7955.
5. Davis A.P., Perry J.J., Williams R.P. J. Am. Chem. Soc. 119:1997;1793.
6. McKenna J., McKenna J.M., Thornthwaite D.W. J. Chem. Soc., Chem. Commun. 1977;809.
7. Janout V., Lanier M., Regen S.L. J. Am. Chem. Soc. 118:1996;1573.
8. Cheng Y., Ho D.M., Gottlieb C.R., Kahne D., Bruck M.A. J. Am. Chem. Soc. 114:1992;7319.
9. Venkatasan P., Cheng Y., Kahne D. J. Am. Chem. Soc. 116:1994;6955.
10. Kramer W., Wess G. Eur. J. Clin. Invest. 26:1996;715.
11. Lehmann T., Engels J. Bioorg. Med. Chem. 9:2001;1827.
12. Li C., Peters A.S., Meredith E.L., Allman G.W., Savage P.B. J. Am. Chem. Soc. 120:1998;2961.
13. Moore K.S., Wehrli S., Roder H., Rogers M., Forrest J.N. Jr., McCrimmon D., Zasloff M. Proc. Natl. Acad. Sci. U.S.A. 90:1993;1354.
14. Willemen H.M., de Smet L.C.P.M., Koudijs A., Stuart M.C.A., Heikamp-de Jong I.G.A.M., Marcelis A.T.M., Sudholter E.J.R. Angew. Chem., Int. Ed. 41:2002;4275.
15. Ehrlich J., Bartz Q.R., Smith R.M., Joslyn D.A., Burkholder P.R. Science. 106:1947;417.
16. (b) Ehrlich, J. In Kirk-Othmer Encyclopedia of Chemical Technology, 3rd ed.; Bushy, G. J.; Klingsherg, A.; Nes, L. van, Eds.; John Wiley & Sons: USA; Vol. 2, p 920.
17. Okahata Y., Ando R., Kunitake T. Bull. Chem. Soc. Jpn. 52:1979;3647.
18. Spectral and other data of compounds 11-17.
19. Oakley K.L., Moore C.B., Denning D.W. Antimicrob. Agents Chemother. 42:1998;2726.