Pharmacokinetics and biodistribution of [111In]-avidin and [99mTc]-biotin-liposomes injected in the pleural space for the targeting of mediastinal nodes

Nuclear Medicine and Biology

Volumn 31, Issue 1, 2004, Pages 41-51

  Medina, Luis A ^a   Klipper, Robert ^a   Phillips, William T ^a   Goins, Beth ^a  

^a UNIVERSITY OF TEXAS HEALTH SCIENCE CENTER AT SAN ANTONIO   (United States)

Author keywords

Lymphatics; Mediastinal nodes; Pharmacokinetics; Pleural space; 111In avidin; 99mTc liposomes

Indexed keywords

AVIDIN IN 111; BIOTIN LIPOSOME TC 99; INDIUM 111; RADIOPHARMACEUTICAL AGENT; TECHNETIUM DERIVATIVE; UNCLASSIFIED DRUG; AVIDIN; BIOTIN; DIAGNOSTIC AGENT; INDIUM; LIPOSOME; TECHNETIUM;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; DRUG DISTRIBUTION; DRUG UPTAKE; MALE; MEDIASTINUM LYMPH NODE; NONHUMAN; PLEURA CAVITY; RAT; SCINTIGRAPHY; ANIMAL; ANTIBODY SPECIFICITY; COMPARATIVE STUDY; FEASIBILITY STUDY; INJECTION; LYMPH NODE; MEDIASTINUM; METABOLIC CLEARANCE RATE; METABOLISM; SCINTISCANNING; SPRAGUE DAWLEY RAT; TISSUE DISTRIBUTION;

ANIMALS; AVIDIN; BIOTIN; FEASIBILITY STUDIES; INDIUM RADIOISOTOPES; INJECTIONS; LIPOSOMES; LYMPH NODES; MALE; MEDIASTINUM; METABOLIC CLEARANCE RATE; ORGAN SPECIFICITY; PLEURAL CAVITY; RADIOPHARMACEUTICALS; RATS; RATS, SPRAGUE-DAWLEY; TECHNETIUM; TISSUE DISTRIBUTION;

EID: 1642451812     PISSN: 09698051     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0969-8051(03)00122-7     Document Type: Article

References (31)

1. Grinberg L.M., Abramova F.A., Yampolskaya O.V., Walker D.H., Smith J.H. Quantitative pathology of inhalational anthrax I quantitative microscopic findings . Mod Pathol. 14:2001;482-495.
2. Hann I.M., Prentice H.G. Lipid-based amphotericin B a review of the last 10 years of use . Int J Antimicrob Agents. 17:2001;161-169.
3. Harrington K.J. Liposomal cancer chemotherapy current clinical applications and future prospects . Expert Opin Invest Drugs. 10:2001;1045-1061.
4. Harrington K.J., Rowlinson-Busza G., Syrigos K.N., Uster P.S., Vile R.G., Stewart J.S.W. Pegylated liposomes have potential as vehicles for intratumoral and subcutaneous drug delivery. Clin Cancer Res. 6:2000;2528-2537.
5. Hirano K., Hunt C. Lymphatic transport of liposome-encapsulated agents effects of liposome size following intraperitoneal administration . J Pharm Sci. 74:1985;915-921.
6. Jeong J.M., Saga T., Lee J.L., Koh C. Avidin-biotin system for targeting metastases basic aspects . Torchilin V.P. Handbook of targeted delivery of imaging agents. 1995;305-320 CRC Press.
7. Lopez-Suarez A., Bascunana A., Elvira J., Garcia-del-Rio E., Escribano J.C., Giron J.A. Fatal mediastinal lymph node drainage into the airways of two patients with human immunodeficiency virus-related tuberculosis. Eur J Clin Microbiol Infect Dis. 17:1998;670-671.
8. Moghimi S.M., Rajabi-Siahboomi A.R. Advanced colloid-based systems for efficient delivery of drugs and diagnostic agents to the lymphatic tissues. Prog Biophys Mol Biol. 65:1996;221-249.
9. Montero C., Gimferrer J., Baldo X., Ramirez J. Mediastinal metastasis of ovarian carcinoma. Eur J Obstet Gynecol Reprod Biol. 91:2000;199-200.
10. Ogihara-Umeda I., Sasaki T., Nishigori H. Active removal of radioactivity in the blood circulation using biotin-bearing liposomes and avidin for rapid tumour imaging. Eur J Nucl Med. 20:1993;170-172.
11. Ogihara-Umeda I., Sasaki T., Toyama H., Oda K., Senda M., Nishigori H. Rapid diagnostic imaging of cancer using radiolabeled liposomes. Cancer Detect Prev. 21:1997;490-496.
12. Oussoren C., Storm G. Lymphatic uptake and biodistribution of liposomes after subcutaneous injection III. Influence of surface modification with poly(ethyleneglycol) . Pharm Res. 14:1997;1479-1484.
13. Pantaleo G., Graziosi C., Demarest J.F., Cohen O.J., Vaccarezza M., Gantt K., Muro-Cacho C., Fauci A.S. Role of lymphoid organs in the pathogenesis of human immunodeficiency virus (HIV) infection. Immunol Rev. 140:1994;105-130.
14. Papisov M., Weissleder R. Drug delivery to lymphatic tissue. Crit Rev Ther Drug Carrier Syst. 13:1996;57-84.
15. Papisov M., Weissleder R., Brady T.J. System lymph node targeting with macromolecular imaging agents. Torchilin V.P. Handbook of targeted delivery of imaging agents. 1995;385-401 CRC Press, Inc, Boca Raton, FL.
16. Perez-Soler R., Lopez-Berenstein M., Jahns M., Wright K., Kasi L.P. Distribution and radiolabelled multilamellar liposomes injected intralymphatically and subcutaneously. Int J Nucl Med Biol. 12:1985;262-266.
17. Perez-Soler R., Shin D.M., Siddik Z.H., Murphy W.K., Hubner M., Lee J.L., Khokhar A.R., Hong W.K. Phase I clinical and pharmacological study of liposomes-entrapped NDDP administered intrapleurally in patients with maliganant pleural effusions. Clin Cancer Res. 3:1997;373-379.
18. Phillips W.T., Klipper R., Goins B. Novel method of greatly enhanced delivery of liposomes to lymph nodes. J Pharmacol Exp Ther. 295:2000;309-313.
19. 99mTc-labeled liposomes encapsulating blue dye for identification of the sentinel lymph node. J Nucl Med. 42:2001;446-451.
20. Phillips W.T., Medina L.A., Klipper R., Goins B. A novel approach for the increased delivery of pharmaceutical agents to the peritoneum and associated lymph nodes. J Pharmacol Exp Ther. 303:2002;11-16.
21. Phillips W.T., Rudolph A.S., Goins B., Timmons J.H., Klipper R., Blumhardt R. A simple method for producing a technetium-99m-labeled liposome which is stable in vivo. Nucl Med Biol. 19:1992;539-547.
22. Porter C. Drug delivery to the lymphatic system. Crit Rev Ther Drug Carrier Syst. 14:1997;333-393.
23. Riquet M., Hidden G., Debesse B. Direct lymphatic drainage of lung segments to the mediastinal nodes. J Thorac Cardiovasc Surg. 97:1989;623-632.
24. Sahn S.A. The pleura. Am Rev Respir Dis. 138:1988;184-234.
25. Sakahara H., Saga T. Avidin-biotin system for delivery of diagnostic agents. Adv Drug Delivery Rev. 37:1999;89-101.
26. Shinohara H. Distribution of lymphatic stomata on the pleural surface of the thoracic cavity and the surface topography of the pleural mesothelium in golden hamster. Anat Rec. 249:1997;16-23.
27. 125I. Effect of labeling on distribution and excretion of radioactivity in rats. J Pharm Sci. 88:1999;577-585.
28. Stewart J.C.M. Colorimetric determination of phospholipids with ammonium ferrothiocyanate. Anal Biochem. 104:1980;10-14.
29. Swartz M.A. The Physiology of the lymphatic system. Adv Drug Delivery Rev. 50:2001;3-20.
30. Tortora G.J. Principles of human anatomy. 1989;Harper Collins, New York, NY.
31. Wang N.-S. Anatomy and physiology of pleural space. Clin Chest Med. 6:1985;3-16.