Continuous renal replacement therapies: Anticoagulation in the critically ill at high risk of bleeding

Journal of Nephrology

Volumn 16, Issue 4, 2003, Pages 566-571

  Morabito, Santo ^a   Guzzo, Isabella ^a   Solazzo, Angela ^a   Muzi, Lina ^a   Luciani, Remo ^a   Pierucci, Alessandro ^a  

^a POLICLINICO UMBERTO I   (Italy)

Author keywords

Acute renal failure; Continuous renal replacement therapies; CRRT; CVVH; CVVHD; CVVHDF; Heparin; Protamine; Regional anticoagulation

Indexed keywords

EPARINA VISTER; HEPARIN; PROTAMINE;

ACUTE KIDNEY FAILURE; ADULT; AGED; ANTICOAGULATION; ARTICLE; BLEEDING; BLOOD CLOTTING; BLOOD FILTER; CONTROLLED STUDY; CRITICAL ILLNESS; DOSE CALCULATION; DOSE RESPONSE; DRUG EFFICACY; DRUG HYPERSENSITIVITY; DRUG SAFETY; FEMALE; HEART SURGERY; HIGH RISK PATIENT; HUMAN; KIDNEY TRANSPLANTATION; MAJOR CLINICAL STUDY; MALE; PATIENT MONITORING; PROBABILITY; PROTHROMBIN TIME; RISK ASSESSMENT; STATISTICAL ANALYSIS; THROMBOCYTOPENIA; VALIDATION PROCESS;

ANALYSIS OF VARIANCE; ANTICOAGULANTS; APACHE; BLOOD COAGULATION DISORDERS; BLOOD COAGULATION TESTS; CARDIAC SURGICAL PROCEDURES; COHORT STUDIES; CRITICAL ILLNESS; FEMALE; HEMORRHAGE; HEPARIN; HUMANS; INCIDENCE; INTENSIVE CARE UNITS; KIDNEY FAILURE, ACUTE; MALE; PROBABILITY; PROGNOSIS; PROSPECTIVE STUDIES; PROTAMINES; RENAL REPLACEMENT THERAPY; RISK FACTORS; SEVERITY OF ILLNESS INDEX; STATISTICS, NONPARAMETRIC; SURVIVAL ANALYSIS; THROMBOCYTOPENIA;

EID: 1642435669     PISSN: 11218428     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (20)

1. Ronco C. Continuous renal replacement therapies for the treatment of acute renal failure in intensive care patients. Clin Nephrol 1993; 40: 187-98.
2. Bellomo R, Ronco C, Mehta RL. Nomenclature for continuous renal replacement therapies. Am J Kidney Dis 1996; 28(suppl 3): S2-7.
3. Manns M, Sigler MH, Teehan BP. Continuous renal replacement therapies: An update. Am J Kidney Dis 1998; 32: 185-207.
4. Mehta RL. Anticoagulation during continuous renal replacement therapies. ASAIO J 1994; 40: 931-5.
5. Hirsh J, Raschke B, Warkentin TE, Dalen JE, Deykin D, Poller L. Heparin: Mechanism of action, pharmacokinetics, dosing consideration, monitoring efficacy, and safety. Chest 1995; 108 (suppl 4): S258-75.
6. Abramson S, Niles JL. Anticoagulation in continuous renal replacement therapy. Curr Opin Nephrol Hypertens 1999; 8: 701-7.
7. Mehta RL, Dobos GJ, Ward DM. Anticoagulation in continuous renal replacement procedures. Semin Dial 1992; 5: 61-8.
8. Van De Wetering J, Westendorp RG, Van Der Hoeven JG, Stalk B, Feuth JD, Chang PC. Heparin use in continuous renal replacement procedures: The struggle between filter coagulation and patient hemorrhage. J Am Soc Nephrol 1996; 7: 145-50.
9. Maher JF, Lapierre L, Schreiner GE, Geiger M, Westervelt FB. Regional heparinization for hemodialysis. Technic and clinical experiences. N Engl J Med 1963; 268: 451-6.
10. Lindholm DD, Murray JS. A simplified method of regional heparinization during hemodialysis according to predetermined dosage formula. Trans Am Soc Artif Inter Organs 1964; 10: 92-7.
11. Hampers CL, Blaufox MD, Merrill JP. Anticoagulation rebound after hemodialysis. N Engl J Med 1966; 275: 776-8.
12. Ellison N, Beatty P, Blake DR, Wurzel HA, Mac Vaugh H. Heparin rebound. J Thorac Cardiovasc Surg 1974; 67: 723-9.
13. Kaplan AA, Petrillo R. Regional heparinization for continuous arterio-venous hemofiltration (CAVH). Trans Am Soc Artif Intern Organs 1987; XXXIII: 312-5.
14. Bellomo R, Teede H, Boyce N. Anticoagulation regimens in acute continuous hemodiafiltration: A comparative study. Intensive Care Med 1993; 19: 329-32.
15. Pan CM, Jobes D, Van Riper D. Modified microsample ACT test for heparin monitoring. J Extra Corpor Technol 1996; 28: 16-20.
16. Tan HK, Baldwin I, Bellomo R. Continuous veno-venous hemofiltration without anticoagulation in high-risk patients. Intensive Care Med 2000; 26: 1652-57.
17. Morabito S, Pierucci A, Palumbo R. Early predictive indicators of mortality in patients with acute renal failure associated with multiple organ failure. J Am Soc Nephrol 1997; 8: 204A (abstract).
18. Mehta RL, McDonald BR, Aguilar MM, Ward DM. Regional citrate anticoagulation for continuous arteriovenous hemodialysis in critically ill patients. Kidney Int 1990; 38: 976-81.
19. Palsson R, Niles JL. Regional citrate anticoagulation in continuous venovenous hemofiltration in critically ill patients with a high risk of bleeding. Kidney Int 1999; 55: 1991-7.
20. Ward DM, Mehta RL. Extracorporeal management of acute renal failure patients at high risk of bleeding. Kidney Int 1993; 43 (suppl 41): S237-44.