Analysis of the human hexokinase II promoter in vivo: Lack of insulin response within 4.0 kb

Biochimica et Biophysica Acta - Gene Structure and Expression

Volumn 1676, Issue 2, 2004, Pages 149-154

  Pirinen, Eija ^a   Heikkinen, Sami ^a   Malkki, Mari ^b   Deeb, Samir S ^b   Jänne, Juhani ^a   Laakso, Markku ^a  

^a UNIVERSITY OF EASTERN FINLAND   (Finland)

^b UNIVERSITY OF WASHINGTON   (United States)

Author keywords

Hexokinase II gene; Regulation of transcription; Type 2 diabetes

Indexed keywords

HEXOKINASE; LUCIFERASE;

ANIMAL CELL; ANIMAL TISSUE; ARTICLE; CONTROLLED STUDY; ENZYME ACTIVITY; ENZYME INDUCTION; GENE EXPRESSION; GENE LOCATION; GENETIC TRANSCRIPTION; INSULIN RELEASE; INSULIN RESPONSE; MOUSE; NONHUMAN; PRIORITY JOURNAL; PROMOTER REGION; REPORTER GENE; TRANSGENIC MOUSE;

MUS MUSCULUS;

EID: 1642431744     PISSN: 01674781     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bbaexp.2003.11.007     Document Type: Article

References (18)

1. Wilson J.E. Hexokinases. Rev. Physiol. Biochem. Pharmacol. 126:1995;65-198.
2. Malkki M., Laakso M., Deeb S.S. Structure of the human hexokinase II gene. Biochem. Biophys. Res. Commun. 205:1994;490-496.
3. Printz R.L., Koch S., Potter L.R., O'Doherty R.M., Tiesinga J.J., Moritz S., Granner D.K. Hexokinase II mRNA and gene structure, regulation by insulin and evolution. J. Biol. Chem. 268:1993;5209-5219.
4. Heikkinen S., Suppola S., Malkki M., Deeb S.S., Jänne J., Laakso M. Mouse hexokinase II gene: structure, cDNA, promoter analysis and expression pattern. Mamm. Genome. 11:2000;91-96.
5. Katzen H.M., Schimke R.T. Multiple forms of hexokinase in the rat: tissue distribution, age dependency and properties. Proc. Natl. Acad. Sci. U. S. A. 54:1965;1218-1225.
6. Forest C.D., O'Brien R.M., Lucas P.C., Magnuson M.A., Granner D.K. Regulation of phosphoenolpyruvate carboxykinase gene expression by insulin. Use of the stable transfection approach to locate an insulin responsive sequence. Mol. Endocrinol. 4:1990;1302-1310.
7. Suwanickul A., Morris S.L., Powell D.R. Identification of an insulin-responsive element in the promoter of the human gene for insulin-like growth factor binding protein-1. J. Biol. Chem. 268:1993;17063-17068.
8. Moustaid N., Beyer R.S., Sul H.S. Identification of an insulin response element in the fatty acid synthase promoter. J. Biol. Chem. 269:1994;5629-5634.
9. Ayala J.E., Streeper R.S., Desgrosellier J.S., Durham S.K., Suwanichkul A., Svitek C.A., Goldman J.K., Barr F.G., Powell D.R., O'Brien R.M. Conservation of an insulin response unit between mouse and human glucose-6-phosphatase catalytic subunit gene promoters: transcription factor FKHR binds the insulin response sequence. Diabetes. 48:1999;1885-1889.
10. Nasrin N., Ercolani L., Denaro M., Kong X.F., Kang I., Alexander M. An insulin responsive element in the glyceraldehyde-3-phosphate dehydrogenase gene binds a nuclear protein induced by insulin in cultured cells and by nutritional manipulations in vivo. Proc. Natl. Acad. Sci. U. S. A. 87:1990;5273-5277.
11. Malkki M., Laakso M., Deeb S.S. The human hexokinase II gene promoter: functional characterization and deletion of variants among patients with NIDDM. Diabetologia. 40:1997;1461-1469.
12. Osawa H., Robey R.B., Printz R.L., Granner D.K. Identification and characterization of basal and cyclic AMP response elements in the promoter of the rat hexokinase II gene. J. Biol. Chem. 271:1996;17296-17303.
13. Hogan B., Constantini F., Lacy E. Manipulating the Mouse Embryo. 1986;Cold Spring Harbor Laboratory Press, New York.
14. Chomczynski P., Sacchi N. Single-step method of RNA isolation by acid guanidium thiocyanate-phenol-chloroform extraction. Anal. Biochem. 167:1987;156-159.
15. Engler-Blum G., Meier M., Frank J., Müller G. Reduction of background problems in nonradioactive Northern and Southern blot analyses enables higher sensitivity than 32P-based hybridizations. Anal. Biochem. 210:1993;235-244.
16. Osawa H., Sutherland C., Robey R.B., Printz R.L., Granner D.K. Analysis of the signaling pathway involved in the regulation of hexokinase II gene transcription by insulin. J. Biol. Chem. 271:1996;16690-16694.
17. Mathupala S.P., Rempel A., Pedersen P.L. Glucose catabolism in cancer cells. Isolation, sequence, and activity of the promoter for the type II hexokinase. J. Biol. Chem. 270:1995;16918-16925.
18. Nickenig G., Roling J., Strehlow K., Schnabel P., Bohm M. Insulin induces upregulation of vascular AT1 receptor gene expression by posttranscriptional mechanisms. Circulation. 98:1998;2453-2460.