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Volumn 10, Issue 6, 2004, Pages 1943-1948

Pilot Study Evaluating the Pharmacokinetics, Pharmacodynamics, and Safety of the Combination of Exemestane and Tamoxifen

Author keywords

[No Author keywords available]

Indexed keywords

AROMATASE INHIBITOR; ESTRADIOL; ESTRONE; ESTRONE SULFATE; EXEMESTANE; SELECTIVE ESTROGEN RECEPTOR MODULATOR; TAMOXIFEN;

EID: 1642397469     PISSN: 10780432     EISSN: None     Source Type: Journal    
DOI: 10.1158/1078-0432.CCR-1005-03     Document Type: Article
Times cited : (19)

References (23)
  • 1
    • 0029794922 scopus 로고    scopus 로고
    • Endocrine therapies of breast cancer
    • Goldhirsch A, Gelber RD. Endocrine therapies of breast cancer. Semin Oncol 1996;23:494-505.
    • (1996) Semin Oncol , vol.23 , pp. 494-505
    • Goldhirsch, A.1    Gelber, R.D.2
  • 2
    • 0034128928 scopus 로고    scopus 로고
    • Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: Results of a randomized double-blind trial
    • Kaufmann M, Bajetta E, Dirix LY, et al. Exemestane is superior to megestrol acetate after tamoxifen failure in postmenopausal women with advanced breast cancer: results of a randomized double-blind trial. J Clin Oncol 2001;18:1399-1411.
    • (2001) J Clin Oncol , vol.18 , pp. 1399-1411
    • Kaufmann, M.1    Bajetta, E.2    Dirix, L.Y.3
  • 3
    • 0141836855 scopus 로고    scopus 로고
    • Mature results of a randomized phase II multicenter study of exemestane versus tamoxifen as first-line hormone treatment for postmenopausal women with metastatic breast cancer
    • Paridaens R, Dirix L, Lohrisch C, et al. Mature results of a randomized phase II multicenter study of exemestane versus tamoxifen as first-line hormone treatment for postmenopausal women with metastatic breast cancer. Ann Oncol 2003;14:1391-8.
    • (2003) Ann Oncol , vol.14 , pp. 1391-1398
    • Paridaens, R.1    Dirix, L.2    Lohrisch, C.3
  • 4
    • 17144472154 scopus 로고    scopus 로고
    • Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: A phase II trial
    • Lønning PE, Bajetta E, Murray R, et al. Activity of exemestane in metastatic breast cancer after failure of nonsteroidal aromatase inhibitors: a phase II trial. J Clin Oncol 2000;18:2234-44.
    • (2000) J Clin Oncol , vol.18 , pp. 2234-2244
    • Lønning, P.E.1    Bajetta, E.2    Murray, R.3
  • 5
    • 0019800997 scopus 로고
    • Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3,17-dione and sustained effects in vivo
    • Brodie AMH, Garrett WM, Hendrickson JR. Inactivation of aromatase in vitro by 4-hydroxy-4-androstene-3,17-dione and 4-acetoxy-4-androstene-3, 17-dione and sustained effects in vivo. Steroids 1981; 38:693-702.
    • (1981) Steroids , vol.38 , pp. 693-702
    • Brodie, A.M.H.1    Garrett, W.M.2    Hendrickson, J.R.3
  • 6
    • 0024474020 scopus 로고
    • Aromatase inhibitors in the treatment of advanced breast cancer
    • Miller WT. Aromatase inhibitors in the treatment of advanced breast cancer. Cancer Treat Rev 1989;16:83-93.
    • (1989) Cancer Treat Rev , vol.16 , pp. 83-93
    • Miller, W.T.1
  • 7
    • 0036839717 scopus 로고    scopus 로고
    • An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole and exemestane
    • Buzdar AU, Robertson JFR, Eirmann W, Nabholtz J-M. An overview of the pharmacology and pharmacokinetics of the newer generation aromatase inhibitors anastrozole, letrozole and exemestane. Cancer (Phila) 2002;95:2006-16.
    • (2002) Cancer (Phila) , vol.95 , pp. 2006-2016
    • Buzdar, A.U.1    Robertson, J.F.R.2    Eirmann, W.3    Nabholtz, J.-M.4
  • 8
    • 0032711815 scopus 로고    scopus 로고
    • The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer
    • Lu Q, Liu Y, Long BJ, Grigoryev D, Gimbel M, Brodie A. The effect of combining aromatase inhibitors with antiestrogens on tumor growth in a nude mouse model for breast cancer. Breast Cancer Res Treat 1999;57:183-92.
    • (1999) Breast Cancer Res Treat , vol.57 , pp. 183-192
    • Lu, Q.1    Liu, Y.2    Long, B.J.3    Grigoryev, D.4    Gimbel, M.5    Brodie, A.6
  • 9
    • 0032836573 scopus 로고    scopus 로고
    • Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer
    • Dowsett M, Pfister C, Johnston SRD, et al. Impact of tamoxifen on the pharmacokinetics and endocrine effects of the aromatase inhibitor letrozole in postmenopausal women with breast cancer. Clin Cancer Res 1999;5:2338-43.
    • (1999) Clin Cancer Res , vol.5 , pp. 2338-2343
    • Dowsett, M.1    Pfister, C.2    Johnston, S.R.D.3
  • 10
    • 0035800525 scopus 로고    scopus 로고
    • Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: A sub-protocol of the 'Arimidex and Tamoxifen Alone or in Combination' (ATAC) trial
    • Dowsett M, Cuzick J, Howell A, Jackson I; ATAC Trialists' Group. Pharmacokinetics of anastrozole and tamoxifen alone, and in combination, during adjuvant endocrine therapy for early breast cancer in postmenopausal women: a sub-protocol of the 'Arimidex and Tamoxifen Alone or in Combination' (ATAC) trial. Br J Cancer 2001;85:317-24.
    • (2001) Br J Cancer , vol.85 , pp. 317-324
    • Dowsett, M.1    Cuzick, J.2    Howell, A.3    Jackson, I.4
  • 11
    • 0027285394 scopus 로고
    • Inhibitory effect of combined treatment with the aromatase inhibitor exemestane and tamoxifen on DMBA-induced mammary tumors in rats
    • Zaccheo T, Giudici D, Di Salle E. Inhibitory effect of combined treatment with the aromatase inhibitor exemestane and tamoxifen on DMBA-induced mammary tumors in rats. J Steroid Biochem Mol Biol 1993;44:677-80.
    • (1993) J Steroid Biochem Mol Biol , vol.44 , pp. 677-680
    • Zaccheo, T.1    Giudici, D.2    Di Salle, E.3
  • 13
    • 20644459413 scopus 로고
    • Appraisal of methods for the study of chemotherapy of cancer in man: Comparative therapeutic trial of nitrogen mustard and triethylene thioposphoramide
    • Zubrod CG, Schneiderman M, Frei E, et al. Appraisal of methods for the study of chemotherapy of cancer in man: comparative therapeutic trial of nitrogen mustard and triethylene thioposphoramide. J Chronic Dis 1960;11:7-33.
    • (1960) J Chronic Dis , vol.11 , pp. 7-33
    • Zubrod, C.G.1    Schneiderman, M.2    Frei, E.3
  • 14
    • 0037255847 scopus 로고    scopus 로고
    • Pharmacokinetics of selective estrogen receptor modulators
    • Morello KC, Wurz GT, DeGregorio MW. Pharmacokinetics of selective estrogen receptor modulators. Clin Pharmacokinet 2003;42:361-72.
    • (2003) Clin Pharmacokinet , vol.42 , pp. 361-372
    • Morello, K.C.1    Wurz, G.T.2    DeGregorio, M.W.3
  • 15
    • 0034064563 scopus 로고    scopus 로고
    • LC-MS-MS determination of exemestane in human plasma with heated nebulizer interface following solid-phase extraction in the 96 well plate format
    • Cenacchi V, Barattè S, Cicioni P, Frigerio E, Long J, James C. LC-MS-MS determination of exemestane in human plasma with heated nebulizer interface following solid-phase extraction in the 96 well plate format. J Pharm Biomed Anal 2000;22:451-60.
    • (2000) J Pharm Biomed Anal , vol.22 , pp. 451-460
    • Cenacchi, V.1    Barattè, S.2    Cicioni, P.3    Frigerio, E.4    Long, J.5    James, C.6
  • 16
    • 0030748661 scopus 로고    scopus 로고
    • Endocrine and clinical effects of exemestane (PNU-155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients
    • Johannessen DC, Engan T, Di Salle E, et al. Endocrine and clinical effects of exemestane (PNU-155971), a novel steroidal aromatase inhibitor, in postmenopausal breast cancer patients. Clin Cancer Res 1997;3:1101-8.
    • (1997) Clin Cancer Res , vol.3 , pp. 1101-1108
    • Johannessen, D.C.1    Engan, T.2    Di Salle, E.3
  • 17
    • 1642301769 scopus 로고    scopus 로고
    • Phase I, open-label, randomized crossover study of the pharmacokinetic interaction of toremifene and atamestane (Biomed 777) in healthy postmenopausal women
    • 2002 Dec. 11-14; Hingham, MA: Kluwer Academic Publisher
    • Langecker P, Blanchett D, Lang W, et al. Phase I, open-label, randomized crossover study of the pharmacokinetic interaction of toremifene and atamestane (Biomed 777) in healthy postmenopausal women [poster]. San Antonio Breast Cancer Meeting; 2002 Dec. 11-14; Hingham, MA: Kluwer Academic Publisher, 2002.
    • (2002) San Antonio Breast Cancer Meeting
    • Langecker, P.1    Blanchett, D.2    Lang, W.3
  • 18
    • 8444226374 scopus 로고    scopus 로고
    • Pharmacokinetic and pharmacodynamic interaction of adjuvant tamoxifen and exemestane in postmenopausal women treated for early stage breast cancer
    • 2002 Dec. 11-14; Hingham, MA: Kluwer Academic Publisher
    • Hutson PR, Love RR, Cleary JF, Kim K. Pharmacokinetic and pharmacodynamic interaction of adjuvant tamoxifen and exemestane in postmenopausal women treated for early stage breast cancer [poster]. San Antonio Breast Cancer Meeting; 2002 Dec. 11-14; Hingham, MA: Kluwer Academic Publisher, 2002.
    • (2002) San Antonio Breast Cancer Meeting
    • Hutson, P.R.1    Love, R.R.2    Cleary, J.F.3    Kim, K.4
  • 19
    • 0011308655 scopus 로고    scopus 로고
    • Inhibition of CYP34A does not influence Aromasin (exemestane, EXE) pharmacokinetics (PK) in healthy postmenopausal volunteers (HPV)
    • Jannuzzo MG, Spinelli R, Poggesi I, Cicioni P, Böttiger Y, Bertilsson L. Inhibition of CYP34A does not influence Aromasin (exemestane, EXE) pharmacokinetics (PK) in healthy postmenopausal volunteers (HPV). Eur J Cancer 1999;35(Suppl 4):S294.
    • (1999) Eur J Cancer , vol.35 , Issue.SUPPL. 4
    • Jannuzzo, M.G.1    Spinelli, R.2    Poggesi, I.3    Cicioni, P.4    Böttiger, Y.5    Bertilsson, L.6
  • 20
    • 0001238487 scopus 로고    scopus 로고
    • Pharmacokinetics (PK) of Aromasin (exemestane, EXE) after single and repeated doses in healthy postmenopausal volunteers (HPV)
    • Spinelli R, Jannuzzo MG, Poggesi I, et al. Pharmacokinetics (PK) of Aromasin (exemestane, EXE) after single and repeated doses in healthy postmenopausal volunteers (HPV). Eur J Cancer 1999;35(Suppl 4):S295.
    • (1999) Eur J Cancer , vol.35 , Issue.SUPPL. 4
    • Spinelli, R.1    Jannuzzo, M.G.2    Poggesi, I.3
  • 21
    • 0037157603 scopus 로고    scopus 로고
    • Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: First results of the ATAC randomised trial
    • ATAC Trialists' Group. Anastrozole alone or in combination with tamoxifen versus tamoxifen alone for adjuvant treatment of postmenopausal women with early breast cancer: first results of the ATAC randomised trial. Lancet 2002;359:2131-9.
    • (2002) Lancet , vol.359 , pp. 2131-2139
  • 22
    • 24244478087 scopus 로고    scopus 로고
    • Preclinical studies evaluating the anti-tumor effects of exemestane using the intratumoral aromatase postmenopausal breast cancer model
    • 2002 Dec. 11-14; Hingham, MA: Kluwer Academic Publisher
    • Jelovac D, Long B, Sabnis G, et al. Preclinical studies evaluating the anti-tumor effects of exemestane using the intratumoral aromatase postmenopausal breast cancer model [poster]. San Antonio Breast Cancer Meeting; 2002 Dec. 11-14; Hingham, MA: Kluwer Academic Publisher, 2002.
    • (2002) San Antonio Breast Cancer Meeting
    • Jelovac, D.1    Long, B.2    Sabnis, G.3
  • 23
    • 0038786584 scopus 로고    scopus 로고
    • A physiologic role for testosterone in limiting estrogenic stimulation of the breast
    • Dimitrakakis C, Zhou J, Wang J, et al. A physiologic role for testosterone in limiting estrogenic stimulation of the breast. Menopause 2003;10:292-8.
    • (2003) Menopause , vol.10 , pp. 292-298
    • Dimitrakakis, C.1    Zhou, J.2    Wang, J.3


* 이 정보는 Elsevier사의 SCOPUS DB에서 KISTI가 분석하여 추출한 것입니다.