Novel Mercaptopurine and Thioguanine Analogues: The Reaction of Dimethyl N-Cyanodithioiminocarbonate with Oxo- and Amino-diazoles

Synthetic Communications

Volumn 34, Issue 5, 2004, Pages 805-815

  Alqaradawi, Siham Y ^a   Elgemeie, Galal H ^b  

^a QATAR UNIVERSITY   (Qatar)

^b Helwan University   (Egypt)

Author keywords

4 Aminoantipyrine; Azoloazines; Azoloazoles; Diazoles; Dimethyl N cyanodithioiminocarbonate; Mercaptopurine; Thioguanine

Indexed keywords

4 AMINOPHENAZONE; 6 MERCAPTOPURINE DERIVATIVE; AMINE; CARBONIC ACID DERIVATIVE; DIMETHYL N CYANODITHIOIMINOCARBONATE; METHYLSULFANYL DERIVATIVE; OXIDE; SULFUR DERIVATIVE; THIOGUANINE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; DRUG SCREENING; DRUG STRUCTURE; DRUG SYNTHESIS;

EID: 1642378096     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120028352     Document Type: Article

References (5)

1. Elgemeie, G.E.H.; Elghandour, A.H.; Elzanate, A.M.; Masoud, W.A. Novel N-substituted amino-4-methylsulfanyl-2-pyridones and deazapurine analogues from ketene dithioacetals. J. Chem. Research (S) 1998, 164-165.
2. Elgemeie, G.H.; Ali, H.A.; Elghandour, A.H.; Abd-Elaziz, G.W. Synthesis of novel derivatives of 4-methylthio-N-aryl-2-pyridone and deazapurine analogues: the reaction of ketene dithioacetals with substituted acetanilides. Phosphurs, Sulfur and Silicon 2000, 164, 189-197.
3. Elgemeie, G.H.; Elghandour, A.H.; Elzanate, A.M.; Ahmed, S.A. Synthesis of some novel α-cyanoketene S,S-acetals and their use in heterocyclic synthesis. J. Chem. Soc. Perkin Trans. 1 1997, 3285-3289.
4. Elgemeie, G.H.; Ali, H.A.; Elzanate, A.M. The reaction of cyanoketene dithioacetals with imidazolidiones: a synthesis of methylsulfanylpyrrolo[1,2-c]imidazolones. J. Chem. Research (S) 1996, 340-341.
5. Elgemeie, G.H.; El-Ezbawy, S.R.; Ali, H.A.; Mansour, A.K. Novel synthesis of mercaptopurine and pentaaza-as-indacene analogues: reaction of [bis(methylthio)methylene]malononitrile and ethyl 2-cyano-3,3-bis-(methylthio)acrylate with 5-aminopyrazoles. Bull. Chem. Soc. Japan 1994, 67, 738-748.