Precautionary defaults - A new strategy for chemical risk management

Human and Ecological Risk Assessment

Volumn 10, Issue 1 SPEC. ISS., 2004, Pages 1-18

  Sandin, Per ^a   Bengtsson, Bengt Erik ^b   Bergman, Åke ^b   Brandt, Ingvar ^c   Dencker, Lennart ^c   Eriksson, Per ^c   Förlin, Lars ^d   Larsson, Per ^e   Oskarsson, Agneta ^f   Rüden, Christina ^a   Södergren, Anders ^e   Woin, Per ^e   Hansson, Sven Ove ^a  

^a ROYAL INSTITUTE OF TECHNOLOGY   (Sweden)

^b STOCKHOLM UNIVERSITY   (Sweden)

^c UPPSALA UNIVERSITY   (Sweden)

^d UNIVERSITY OF GOTHENBURG   (Sweden)

^e LUND UNIVERSITY   (Sweden)

^f SWEDISH UNIVERSITY OF AGRICULTURAL SCIENCES   (Sweden)

Author keywords

Chemicals; Precautionary defaults; Precautionary Principle; Risk management

Indexed keywords

EID: 1642370560     PISSN: 10807039     EISSN: None     Source Type: Journal    
DOI: 10.1080/10807030490280909     Document Type: Review

References (84)

1. Allanou R, Hansen BG, and van der Bilt Y. 1999. Public Availability of Data on EU High Production Volume Chemicals. European Commission EUR 18996 EN. Institute for Health and Consumer Protection, Ispra, Italy
2. Anderson HA and Wolff MS. 2000. Environmental contaminants in human milk. J Exposure Anal Environ Epidemiol 10:755-60
3. Auman HJ, Ludwig JP, Summer CL, et al. 1997. PCBs, DDE, DDT, and TCDD-EQ in two species of albatross on Sand Island, Midway Atoll, North Pacific Ocean. Environ Toxicol Chem 16:498-504
4. Bahrami F, Bergman U, Brittebo E-B, et al. 2000. Persistent olfactory mucosal metaplasia and increased olfactory bulb glial fibrillary acidic protein levels following a single dose of methylsulfonyl-dichlorobenzene in mice: Comparison of the 2,5- and 2,6-dichlorinated isomers. Toxicol Appl Pharmacol 162:49-59
5. Ballarin-Denti A, Bertazzi PA, Facchetti S, et al. (eds.) 1999. Chemistry, Man and Environment - The Seveso Accident 20 Years On: Monitoring, Epidemiology and Remediation. Elsevier, Amsterdam, The Netherlands
6. Bartus RT, Dean III RL, Beer B, et al. 1982. The cholinergic hypothesis of geriatric memory dysfunction. Science 217:408-17
7. Bernhoft A, Wiig Å, and Utne-Staare J. 1997. Organochlorine in polar bears (Ursus maritimus) at Svalbard. Environ Pollution 95:159-75
8. Bishop WE, Clarke DP, and Travis CC. 2001. The genomic revolution: What does it mean for risk assessment? Risk Anal 21:983-7
9. Bolles RG and Woods PJ. 1964. The ontogeny of behaviour in the albino rat. Anim Behav 12:427-41
10. Breitholtz M, Hill C, and Bengtsson B-E. 2001. Toxic substances and reproductive disorders in Baltic fish and crustaceans. Ambio 30:210-6
11. Breitholtz M, Wollenberger L, and Dinari L. In press. Effects of four synthetic musks on the life-cycle of the harpacticoid copepod Nitocra spinpes. Aquatic Toxicol
12. Brouwer A, Morse DC, Lans MC, et al. 1998. Interactions of persistent environmental organohalogens with the thyroid hormone system: Mechanisms and possible consequences for animal and human health. J Toxicol Industr Health 14:59-84
13. Campbell BA, Lytle LD, and Fibiger HC. 1969. Ontogeny of adrenergic arousal and cholinergic inhibitory mechanisms in the rat. Science 166:635-7
14. Chen H, Liu J, Merrick BA, et al. 2001. Genetic events associated with arsenic-induced malignant transformation: Applications of cDNA microarray technology. Mol Carcinog 30:79-87
15. Council Directive (EEC) 67/548 of 27 June 1967 on the approximation of laws, regulations and administrative provisions relating to the classification, packaging and labeling of dangerous substances. Off Jour 196:1-5
16. Davison AN and Dobbing J. 1968. Applied Neurochemistry, pp 178-221, 253-316. Blackwell, Oxford, UK
17. de March BGE, de Wit CA, and Muir DCG. 1998. Persistent organic pollutants. Assessment Report: Arctic Pollution Issues, Arctic Monitoring And Assessment Programme (AMAP):183-371
18. deFur PL, Crane M, Ingersoll C, et al., eds. 1999. Endocrine Disruption in Invertebrates: Endocrinology, Testing, and Assessment. SETAC Technical Publication, Pensacola, FL, USA
19. Drachman DA. 1977. Cognitive function in man. Does the cholinergic system have a special role? Neurology 27:783-90
20. EC (European Commission). 2001. Strategy for a future chemicals policy. White Paper COM (2001) 88 Final. Brussels, Belgium
21. Eriksson P. 1998. Perinatal Developmental Neurotoxicity of PCBs. Report 4897. Swedish Environmental Protection Agency, Stockholm, Sweden
22. Eriksson P and Fredriksson A. 1996a. Developmental neurotoxicity of four ortho-substituted polychlorinated biphenyls in the neonatal mouse. Environ Toxicol Pharmacol 1:155-65
23. Eriksson P and Fredriksson A. 1996b. Neonatal exposure to 2,2′,5,5′-tetrachlorobiphenyl causes increased susceptibility in the cholinergic transmitter system at adult age. Environ Toxicol Pharmacol 1:217-20
24. Eriksson P and Fredriksson A. 1998. Neurotoxic effects in adult mice neonatally exposed to 3,3′,4,4′5-pentachlorobiphenyl or 2,3,3′,4,4′-pentachlorobiphenyl. Changes in brain nicotinic receptors and behaviour. Environ Toxicol Pharmacol 5:17-27
25. Eriksson P, Jakobsson E, and Fredriksson A. 2001. Brominated flame retardants: A novel class of developmental neurotoxicants in our environment. Environ Health Perspect 109:903-8
26. Eriksson P, Viberg H, Jakobsson E, et al. 2002. A brominated flame retardant, 2,2′4,4′,5-pentabromodiphenyl ether: Uptake, retention and induction of neurobehavioural derangement in mice, during a critical phase of neonatal brain development. Toxicol Sci 67:98-103
27. Fairs NJ, Evershed RP, Quinlan PT, et al. 1989. Detection of unconjugated and conjugated steroids in the ovary, eggs, and haemolymph of the decapod crustacean Nephrops norvegicus. Gen Comp Endocrinol 74:199-208
28. Fängström B, Athanassiadis I, Athanasiadou M, et al. 2001. Hydroxylated PCB metabolites in non-hatched Faroe Islands Fulmar eggs. Organohalogen Compounds 52:112-5
29. Girling AE, Pascoe D, Janssen CR, et al. 2000. Development of methods for evaluating toxicity to freshwater ecosystems. Ecotoxicol Environ Saf 45:148-76
30. Hanski I. 1997. Be diverse, be predictable. Nature 390:440-1
31. Hansson SO. 1995. The detection level. Regul Toxicol Pharmacol 22:103-9
32. Hansson SO. In press. Philosophical perspectives on risk. Proceedings of the Conference Research in Ethics and Engineering (Delft, April 25-27, 2002)
33. Hansson SO. 2002. Replacing the No Effect Level (NOEL) with Bounded Effect Levels (OBEL and LEBEL). Statistics in Medicine 21:3071-8
34. Herschkowitz N, Kagan J, and Zilles K. 1997. Neurobiological bases of behavioural development in the first year. Neuropediatrics 28:296-306
35. Hovander L, Malmberg T, Athanasiadou M, et al. 2002. Identification of hydroxylated PCB metabolites and other phenolic pollutants in human blood plasma. Arch Environ Contam Toxicol 42:105-17
36. IARC (International Agency for Research on Cancer). 2000. IARC Monographs on the Evaluation of Carcinogenic Risks to Humans 77. Some Industrial Chemicals. Lyon, France
37. Joern A and Hoagland KD. 1996. In defense of whole-community bioassays for risk assessment. Environ Toxicol Chem 15:407-9
38. Karczmar AG. 1975. Cholinergic influences on behaviour. In: Waser PG (ed), Cholinergic Mechanisms, pp 501-29. Raven Press, New York, NY, USA
39. Klasson Wehler E, Bergman Å, Athanasiadiou M, et al. 1998. Hydroxylated and methylsulfonyl polychlorinated biphenyl metabolites in albatrosses from Midway atoll, North Pacific Ocean. Environ Toxicol Chem 17:1620-5
40. LaKind JS, Berlin CM, and Naiman DQ. 2001. Infant exposure to chemicals in breast milk in the Unites States: What we need to learn from a breast milk monitoring program. Environ Health Perspect 109:75-88
41. Larsson P, Andersson A, Broman D, et al. 2000. Persistent organic pollutants (POPs) in pelagic systems. Ambio 29:202-9
42. Leboulanger C, Rimet F, de Lacotte MH, et al. 2001. Effects of atrazine and nicosulfuron on freshwater microalgae. Environ Internat 26(3):131-5
43. Lee RGM, Hung H, Mackay D, et al. 1998. Measurement and modelling of the diurnal cycling of atmospheric PCBs and PAHs. Environ Sci Technol 32:2172-9
44. Letcher RJ, Norstrom RJ, and Bergman Å. 1995. Geographical distribution and identification of methyl sulphone PCB and DDE metabolites in pooled polar bear (Ursus maritimus) adipose tissue from western hemisphere arctic and subarctic regions. Sci Total Environ 160/161:409-20
45. Lindhe Ö, Lund B-O, Bergman Å, et al. 2001. Irreversible binding and adrenocorticolytic activity of the DDT metabolite 3-methylsulfonyl-DDE examined in tissue slice culture. Environ Health Perspect 109:105-10
46. Matikainen T, Perez GI, Jurisicova A, et al. 2001. Aromatic hydrocarbon receptor-driven Bax gene expression is required for premature ovarian failure caused by biohazardous environmental chemicals. Nat Genet Aug 28:355-60
47. Muir DCG, Ford CA, Grift NP, et al. 1992. Organochlorine contaminants in narwhal (Monodon monoceros) from the Canadian Arctic. Environ Pollut 75:307-16
48. Niederlehner BR and Cairns J. 1994. Consistency and sensitivity of community level endpoints in microcosm tests. J Aquat Ecosys Health 3:93-9
49. Norén K. 1983a. Some aspects of the determination of organochlorine contaminants in human milk. Arch Environ Contam Toxicol 12:277-83
50. Norén K. 1983b. Levels of organochlorine contaminants in human milk in relation to the dietary habits of the mothers. Acta Paedr Scand 72:811-6
51. Norén K and Meironyté D. 2000. Certain organochlorine and organobromine contaminants in Swedish human milk in perspective of past 20-30 years. Chemospere 40:1111-23
52. Norstrom RJ, Simon M, Muir DCG, et al. 1988. Organochlorine contaminants in Arctic marine food chains: Identification, geographical distribution and temporal trends in polar bears. Environ Sci Technol 22:1063-71
53. Novak F, Van Beek E, Lambert J, et al. 1990. Pregnenolone and estradiol identification in the brine shrimp, Artemia sp., by means of gas chromatographical-mass spectrometrical analysis. Comp Biochem Physiol 95B:565-9
54. NRC (U.S. National Research Council). 1984. Toxicity Testing Strategies to Determine Needs and Priorities. National Academy Press, Washington, DC, USA
55. Nuwaysir EF, Bittner M, Trent J, et al. 1999. Microarrays and toxicology: The advent of toxicogenomics. Mol Carcinog 24:153-9
56. Rodier PM, Ingram JL, Tisdale B, et al. 1996. Embryological origin for autism: Developmental anomalies of the cranial nerve motor nuclei. J Comp Neurol 370:247-61
57. Roe D, Pease W, Florini K, et al. 1997. Toxic Ignorance. Environmental Defense Fund (EDF), Washington, DC, USA
58. Rogers JM and Kavlock RL. 1996. Developmental toxicology. In: Klaassen CD, ed, Casarett's and Doull's Toxicology: The Basic Science of Poisons, pp 301-31. McGraw-Hill, New York, NY, USA
59. Ross PS, Ellis GM, Ikonomu, MG, et al. 2000. High PCB concentrations in free ranging Pacific killer whales, Orcinus orca: Effects of age, sex and dietary preferences. Mar Pollut Bull 40:504-15
60. Sandau CD, Meerts IATM, Letcher RJ, et al. 2000a. Identification of 4-hydroxyheptachlorostyrene in polar bear plasma and its binding affinity to transthyretin: A metabolite of octachlorostyrene? Environ Sci Technol 34:3871-7
61. Sandau CD, Ramsay MA, and Norstrom RJ. 2000b. Implications of hydroxylated metabolites of PCBs and other halogenated phenolic compounds as endocrine disruptors in polar bear. In: Proceedings of the Third biennial international conference on chemical measurement and monitoring of the environment, pp 247-52. Ottawa, ON, Canada
62. Sandin P. 1999. Dimensions of the precautionary principle. Hum Ecol Risk Assess 5:889-907
63. Sandin P and Hansson SO. 2002. The default value approach to the precautionary principle. Hum Ecol Risk Assess 8:463-71
64. Sandin P, Peterson M, Hansson SO, et al. 2002. Five charges against the precautionary principle. J Risk Res 5:287-99
65. Scheffler T. 2001. Toxic threats to neurologic development of children. Environ Health Perspect 109(suppl. 6):813-6
66. Seguin F, Leboulanger C, Rimet F, et al. 2001. Effects of Atrazine and Nicosulfuron on phytoplankton in systems of increasing complexity. Arch Environ Contam Toxicol 40:198-208
67. Simonich SL and Hites RA. 1995. Global distribution of persistent organic compounds. Science 269:1851-4
68. Smith LL. Key challenges for toxicologists in the 21st century. 2001. Trends Pharmacol Sci. 22:281-5
69. Solomon GM and Weiss PM. 2002. Chemical contaminants in breast milk: Time trends and regional variability. Environ Health Perspect 110:A339-A47
70. Sriramachari S and Chandra H. 1997. The lessons of Bophal[toxic] MIC gas disaster: Scope for expanding global biomonitoring and environmental specimen banking. Chemosphere 34:2237-50
71. Subramanian A, Tanabe S, Hidaka, H, et al. 1986. Bioacumulation of organochlorines (PCBs and P,P'DDE) in Antarctic Adelie Penguins Pygosceils adeliae collected during a breeding season. Environ Pollution 40:173-89
72. Subramanian AN, Tanabe S, Tanaka H, et al. 1987. Gain and loss rates and biological half-life of PCBs and DDE in the bodies of adelie penguins. Environ Pollution 43:39-46
73. Taub FB. 1997. Unique information contribution by multispecies systems: Examples from the standardized aquatic microcosm. Ecol Appl 7:1103-10
74. Thomas RS, Rank DR, Penn SG, et al. 2001. Identification of toxicologically predictive gene sets using cDNA microarrays. Mol Pharmacol. 60:1189-94
75. USEPA (U.S. Environmental Protection Agency). 1999. Guidelines for Carcinogen Risk Assessment. DRAFT NCEA-F-0644. Washington, DC, USA
76. van Leeuwen C and Hermens JLM. 1995. Risk Assessment of Chemicals - An Introduction. Kluwer Academic Publishers, London, UK
77. Viberg H, Fredriksson A, and Eriksson P. In press. Neonatal exposure to the brominated flame-retardant, 2,2′,4,4′,5-pentabromodiphenyl ether, causes increased susceptibility in the cholinergic transmitter system at adult age. Toxicol Sci
78. Waid S. 1986. PCBs and the Environment I-III. CRC Press, Boca Raton, FL, USA
79. Wania F and Mackay D. 1993. Global fractionation and cold condensation of low volatility organochlorine compounds in polar regions. Ambio 22:10-8
80. Wania F and Mackay D. 1996. Tracking the distribution of persistent organic pollutants. Environ Sci Technol 30:390A-6A
81. Waring JF, Jolly RA, Ciurlionis R, et al. 2001. Clustering of hepatotoxins based on mechanism of toxicity using gene expression profiles. Toxicol Appl Pharmacol 175:28-42
82. WHO (World Health Organization). 1989. Environmental Health Criteria 83. DDT and Its Derivatives - Environmental Aspects. International Programme on Chemical Safety, Geneva, Switzerland
83. WHO (World Health Organization). 2002. Exposure of selected potential endocrine disrupting chemicals in humans and wildlife. In: Damstra T, Barlow S, Bergman Å, et al., eds, Global Assessment of the State-of-Science of Endocrine Disruptors. International Programme on Chemical Safety, Geneva, Switzerland
84. Wilson JT, Brown RD, Cherek DR, et al. 1980. Drug excretion in human breast milk. Clin Pharmacokinetics 5:1-66