Synthesis of New 4,5-Dihydro-3(2H)-pyridazinone Derivatives

Synthetic Communications

Volumn 34, Issue 5, 2004, Pages 783-793

  Meyer, E ^a   Joussef, A C ^a   Gallardo, H ^a   De Souza, L De B P ^a  

^a FEDERAL UNIVERSITY OF SANTA CATARINA   (Brazil)

Author keywords

Angiotensin II; Blood pressure; Pyridazinone; Renin angiotensin system

Indexed keywords

4,5 DIHYDRO 3(2H) PYRIDAZINONE DERIVATIVE; ANGIOTENSIN 2 RECEPTOR ANTAGONIST; EPROSARTAN; HETEROCYCLIC COMPOUND;

ARTICLE; BLOOD PRESSURE; DRUG STRUCTURE; DRUG SYNTHESIS; RENIN ANGIOTENSIN ALDOSTERONE SYSTEM; STRUCTURE ANALYSIS;

EID: 1642369966     PISSN: 00397911     EISSN: None     Source Type: Journal    
DOI: 10.1081/SCC-120028351     Document Type: Article

References (15)

1. Burnier, M. Angiotensin II type 1 receptor blockers. Circulation 2001, 103 (6), 904-912.
2. Goodfriend, T.L. Angiotensin receptors: history and mysteries. Am. J. Hypertens. 2000, 13 (4), 442-449.
3. Wexler, R.R.; Greenlee, W.J.; Irvin, J.D.; Goldberg, M.R.; Prendergast, K.; Smith, R.D.; Timmermans, P.B.M.W.M. Nonpeptide angiotensin II receptor antagonists: the next generation in antihypertensive therapy. J. Med. Chem. 1996, 39 (3), 625-656.
4. Kurup, A.; Garg, R.; Carini, D.J.; Hansch, C. Comparative QSAR: angiotensin II antagonists. Chem. Rev. 2001, 101 (9), 2727-2750.
5. Krovat, E.M.; Langer, T.J. Non-peptide angiotensin II receptor antagonists: chemical feature based pharmacophore identification. J. Med. Chem. 2003, 46 (5), 716-726.
6. 1 receptor antagonists. Clinical implications of active metabolites. J. Med. Chem. 2003, 46 (12), 2261-2270.
7. Keenan, R.M.; Weinstock, J.; Finkelstein, J.A.; Franz, R.G.; Gaitanopoulos, D.E.; Girard, G.R.; Hill, D.T.; Morgan, T.M.; Samanen, J.M.; Peishoff, C.E.; Tucker, L.M.; Aiyar, N.; Griffin, E.; Ohlstein, E.H.; Stack, E.J.; Weidley, E.F.; Edwards, R.M. Potent nonpeptide angiotensin II receptor antagonists. 2. 1-(Carboxybenzyl)imidazole-5-acrylic acids. J. Med. Chem. 1993, 36 (13), 1880-1892.
8. Meyer, E.; Joussef, A.C.; Gallardo, H. Synthesis of new 1,2,4- and 1,3,4-oxadiazole derivatives. Synthesis 2003 (6), 899-905.
9. Meyer, E.; Joussef, A.C.; Gallardo, H.; Bortoluzzi, A.J. Structural characterization of two oxadiazolic systems used as spacers for potential angiotensin II receptor antagonists. J. Mol. Struc. 2003, 655, 361-368.
10. Tóth, G.; Kövér, K.E. Simple, safe, large scale synthesis of 5-arylmethyl-2,2-dimethyl-1,3-dioxane-4,6-diones and 3-arylpropanoic acids. Synth. Commun. 1995, 25 (19), 3067-3074.
11. Tóth, G.; Molnár, S.; Tamás, T.; Borbély, I. An efficient synthesis of 4,5-dihydro-3(2H)-pyridazinone derivatives. Synth. Commun. 1997, 27 (20), 3513-3523.
12. Davidson, D.; Bernhard, S.A. The structure of Meldrum's supposed β-lactonic acid. J. Am. Chem. Soc. 1948, 70 (10), 3426-3428.
13. Dhanoa, D.S.; Bagley, S.W.; Chang, R.S.L.; Lotti, V.J.; Chen, T.; Kivlighn, S.D.; Zingaro, G.J.; Siegl, P.K.S.; Chakravarty, P.K.; Patchett, A.A. ; Greenlee, W.J. (Dipropylphenoxy)phenylacetic acids: a new generation of nonpeptide angiotensin II receptor antagonists. J. Med. chem. 1993, 36 (23), 3738-3742.
14. McKillop, A.; Fiaud, J.-C.; Hug, R.P. The use of phase-transfer catalysis for the synthesis of phenol ethers. Tetrahedron 1974, 30 (11), 1379-1382.
15. Fluka Catalogue, A Sigma-Aldrich Company, 2003/2004.