A rapid and efficient synthesis of 2-butyl-5-chloro-3H-imidazole-4- carboxaldehyde

Synthesis

Volumn , Issue 4, 2004, Pages 506-508

  Srinivas, K ^a   Snehalatha Nair, C K ^a   Ramesh, S ^a   Pardhasaradhi, M ^a  

^a INDIAN INSTITUTE OF CHEMICAL TECHNOLOGY   (India)

Author keywords

Imidates; Imidazole; Nitrile; Tetrazole; Vilsmeier reagents

Indexed keywords

COST EFFECTIVENESS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; PURIFICATION; SYNTHESIS (CHEMICAL);

ACID-BASE TREATMENT; ISOLATION PROCESSES;

ALDEHYDES;

2 BUTYL 5 CHLORO 3H IMIDAZOLE 4 CARBOXALDEHYDE; ALDEHYDE; ANGIOTENSIN RECEPTOR ANTAGONIST; HYDROCHLORIC ACID; IMIDAZOLE DERIVATIVE; LOSARTAN POTASSIUM; METHANOL; METHYL PENTANIMIDATE; NITRILE; REAGENT; TETRAZOLE DERIVATIVE; UNCLASSIFIED DRUG; VALERONITRILE; VILSMEIER REAGENT;

ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CHLORINATION; COST EFFECTIVENESS ANALYSIS; DRUG PURIFICATION; DRUG SYNTHESIS; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH TEMPERATURE; OXIDATION; PROTON NUCLEAR MAGNETIC RESONANCE;

EID: 1642351480     PISSN: 00397881     EISSN: None     Source Type: Journal    
DOI: 10.1055/s-2004-815961     Document Type: Article

References (15)

1. Duncia, J. V.; Carini, D. J.; Chiu, A. T.; Pierce, M. E.; Smith, R. D.; Wells, G. J.; Wang, P. C.; Wexier, P. R.; Johnson, A. L.; Timmermans, P. B. M. W. M. Drugs Fut. 1991, 16, 305.
2. Carini, D. J.; Duncia, J. V.; Aldrich, P. E.; Chiu, A. T.; Johnson, A. L.; Pierce, M. E.; Price, W. A.; Santella, J. B. III; Wells, G. J.; Wexler, R. R.; Wong, P. C.; Yoo, S. E.; Timmermans, P. B. M. W. M. J. Med. Chem. 1991, 34, 2525; and references reported therein.
3. Scrip 1994, 1963, 23.
4. Takeda Chemical Industries Ltd., JP 5798270, 1982; Chem. Abstr. 1983, 98, 4543a.
5. Yamamoto, T.; Hibi, Y.; Ogawa, T. US Patent 5395943, 1995.
6. Elz, S.; Kramer, K.; Pertz, H. H.; Detert, H.; Laak, A. K.; Kuhne, R.; Schunack, W. J. Med. Chem. 2000, 43, 1073.
7. Furukawa, Y.; Kishimoto, S.; Nishikawa, K. US Patent 4355040, 1982.
8. Basappa, M. P. S.; Mantelingu, K.; Swamy, S. N.; Rangappa, K. S. Bioorg. Med. Chem. 2003, 11, 4539.
9. Pardhasaradhi, M.; Srinivas, K.; Snehalatha Nair, C. K. US patent 6326498, 2001; Chem. Abstr. 2001, 136, 5996.
10. Srinivas, K.; Snehalatha Nair, C. K.; Ramesh, S.; Pardhasaradhi, M. Org. Prep. Proced. Int. 2003, 35, 537.
11. Dzurion, P.; Schunarck, W. Arch. Phamazie 1974, 307, 470.
12. Shi, Y.-J.; Frey, L. F.; Tschaeu, D. M.; Verhoeven, T. R. Synth. Commun. 1993, 23, 2623.
13. Griffiths, G. J. Chimia 1997, 51, 283.
14. Griffiths, G. J.; Hauck, M. B.; Imwinkelried, R.; Kohr, J.; Roten, C.; Stucky, G. C. J. Org. Chem. 1999, 64, 8084.
15. Pardhasaradhi, M.; Srinivas, K.; Snehalatha Nair, C. K.; Ramesh, S. Indian Patent NF132, 2002.