Pharmacokinetic and immunosuppressive effects of tacrolimus-loaded biodegradable microspheres

Liver Transplantation

Volumn 10, Issue 3, 2004, Pages 392-396

  Miyamoto, Yasunori ^a   Uno, Takeji ^b   Yamamoto, Hiromitsu ^c   Xiao Kang, Li ^d   Sakamoto, Koh Ichi ^b   Hashimoto, Hisakuni ^a   Takenaka, Hirofumi ^c   Kawashima, Yoshiaki ^c   Kawarasaki, Hideo ^b  

^a HAMAMATSU UNIVERSITY SCHOOL OF MEDICINE   (Japan)

^b JICHI MEDICAL UNIVERSITY   (Japan)

^c GIFU PHARMACEUTICAL UNIVERSITY   (Japan)

^d NATIONAL RESEARCH INSTITUTE FOR CHILD HEALTH AND DEVELOPMENT   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

MICROSPHERE; TACROLIMUS;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; BIODEGRADABILITY; BONE MARROW; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; CORRELATION ANALYSIS; DOSE RESPONSE; DRUG BLOOD LEVEL; DRUG DELIVERY SYSTEM; DRUG LYMPH LEVEL; DRUG RELEASE; DRUG TISSUE LEVEL; DRUG UPTAKE; GRAFT REJECTION; IMMUNOSUPPRESSIVE TREATMENT; INJECTION SITE; LINEAR REGRESSION ANALYSIS; LIVER TRANSPLANTATION; LYMPH NODE; NONHUMAN; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; RAT; RAT STRAIN; RECIPIENT; SINGLE DRUG DOSE; STATISTICAL SIGNIFICANCE; SURVIVAL TIME; SUSTAINED DRUG RELEASE;

ANIMALS; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG DELIVERY SYSTEMS; IMMUNOSUPPRESSIVE AGENTS; INJECTIONS, SUBCUTANEOUS; LIVER TRANSPLANTATION; LYMPH NODES; MALE; MICROSPHERES; RATS; TACROLIMUS;

EID: 1642343796     PISSN: 15276465     EISSN: None     Source Type: Journal    
DOI: 10.1002/lt.20083     Document Type: Article

References (15)

1. Todo S, Fung JJ, Starzl TE, et al. Liver, kidney, and thoracic organ transplantation under FK 506. Ann Surg 1990;212:295-307.
2. Venkataramanan R, Jain A, Cadoff E, Warty V, Iwasaki K, Nagase K. Pharmacokinetics of FK506: Preclinical and clinical studies. Transplant Proc 1990;22:52-56.
3. Brodin AF, Kavaliunas DR, and Frank SG. Prolonged drug release from multiple emulsions. Acta Pharm Suecica 1978;15: 1-12.
4. Yoshikawa H, Muranishi S, Sugihara N, and Sezaki H. Mechanism of transfer of bleomycin into lymphatics by bifunctional delivery system via lumen of small intestine. Chem Pharm Bull 1983;31:1726-1732.
5. Kagayama A, Kimura S, Murata S, Tanimoto S, and Hata T. Prolonged-action pharmaceutical preparation, European patent specification. 1992; International Publication Number: WO 94/10981, 1-13.
6. Kamada N. Experiments in animals. In: Calne, SR, Roser BJ, Zimmerman F, Davies HS, eds. Liver transplantation, 2nd ed. New York: Grune & Stratton, Inc. 1987:25-34.
7. Grenier FC, Luczkiw J, Bergmann M, et al. A whole blood FK506 assay for the IMx analyzer. Transplant Proc 1991;23: 2748-2749.
8. Cleland JL. Solvent evaporation processes for the production of controlled release biodegradable microsphere formulations for therapeutics and vaccines. Biotechnol Prog 1998;14:102-107.
9. Molpeceres J, Aberturas MR, and Guzman M. Biodegradable nanoparticles as a delivery system for cyclosporine: Preparation and characterization. J Microencapsul 2000;17:599-614.
10. Urata T, Arimori K, and Nakano H. Modification of release rates of cyclosporine A from polyl (L-lactic acid) microspheres by fatty acid esters and in vivo evaluation of the microspheres. J Control Release 1999;58:133-141.
11. Ko S, Nakajima Y, Kanehiro H, Yoshimura A, and Nakano, H. The pharmacokinetic benefits of newly developed liposome-incorporated FK506. Transplantation 1994;58:1142-1144.
12. Uno T, Yamaguchi T, Li XK, et al. The pharmacokinetics of water-in-oil-in-water-type multiple emulsion of a new tacrolimus formulation. Lipids 1997;32:543-548.
13. Uno T, Kazui T, Suzuki Y, Hashimoto H, Suzuki K, and Muhammad BAH. Pharmacokinetic advantages of a newly developed tacrolimus oil-in-water-type emulsion via the enteral route. Lipids 1999;34:249-254.
14. Gruber SA. The case for local immunosuppression. Transplantation 1992;54:1-11.
15. Ko S, Nakajima Y, Kanehiro H, et al. Different immunosuppressive effects of liposomal FK506 in liver and kidney transplantation. Transplant Proc 1996;28:1066-1068.