A renaissance of positive inotropic interventions to treat heart failure?

Cardiovascular Research

Volumn 59, Issue 3, 2003, Pages 534-535

  Neumann, Joachim ^a  

^a UNIVERSITY HOSPITAL MÜNSTER   (Germany)

Author keywords

[No Author keywords available]

Indexed keywords

ALLOPURINOL; BETA ADRENERGIC RECEPTOR STIMULATING AGENT; CALCIUM SENSITIZER; OXIPURINOL; PHOSPHODIESTERASE INHIBITOR; XANTHINE OXIDASE; XANTHINE OXIDASE INHIBITOR;

CELL ISOLATION; CONGESTIVE CARDIOMYOPATHY; DRUG ACTIVITY; DRUG BLOOD LEVEL; DRUG EFFECT; DRUG ELIMINATION; DRUG HALF LIFE; DRUG MECHANISM; DRUG METABOLISM; DRUG POTENCY; EDITORIAL; ENZYME ACTIVITY; EXPERIMENTAL MODEL; GOUT; HEART FAILURE; HEART FUNCTION; HEART MUSCLE CELL; HEART MUSCLE OXYGEN CONSUMPTION; HEART TRANSPLANTATION; HUMAN; INFUSION; INOTROPISM; MOLECULAR MECHANICS; NONHUMAN; OXYGEN SUPPLY; PLASMA HALF LIFE; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROTEIN EXPRESSION; REDUCTION;

ALLOPURINOL; ANIMALS; ENZYME INHIBITORS; FREE RADICALS; HEART FAILURE, CONGESTIVE; HUMANS; MODELS, ANIMAL; MYOCARDIUM; OXYGEN; OXYPURINOL; RATS; XANTHINE OXIDASE;

EID: 1642339022     PISSN: 00086363     EISSN: None     Source Type: Journal    
DOI: 10.1016/S0008-6363(03)00557-1     Document Type: Editorial

References (12)

1. Kögler H., Fraser H., McCune S., Altschuld R., Marban E. Disproportionate enhancement of myocardial contractility by the xanthine oxidase inhibitor oxypurinol in failing rat myocardium. Cardiovasc Res. 59:2003;582-592.
2. Gao W.D., Liu Y., Marban E. Selective effects of oxygen free radicals on excitation-contraction coupling in ventricular muscle. Implications for the mechanism of stunned myocardium. Circulation. 94:1996;2597-2604.
3. Castelli P., Condemi A.M., Brambillasca C., Fundaro P., Botta M., Lemma M., Vanelli P., Santoli C., Gatti S., Riva E. Improvement of cardiac function by allopurinol in patients undergoing cardiac surgery. J Cardiovasc Pharmacol. 25:1995;119-125.
4. Johnson W.D., Kayser K.L., Brenowitz J.B., Saedi S.F. A randomized controlled trial of allopurinol in coronary bypass surgery. Am Heart J. 121:1991;20-24.
5. Cappola T.P., Kass D.A., Nelson G.S., Berger R.D., Rosas G.O., Kobeissi Z.A., Marban E., Hare J.M. Allopurinol improves myocardial efficiency in patients with idiopathic dilated cardiomyopathy. Circulation. 104:2001;2407-2411.
6. 2+- sensitizing property of xanthine oxidase inhibitors. Circ Res. 83:1998;423-430.
7. Neumann J., Eschenhagen T., Grupp I.L., Haverich A., Herzig J.W., Hirt S., Kalmar P., Schmitz W., Scholz H., Stein B., Wenzlaff H., Zimmermann N. Positive inotropic effects of the calcium sensitizer CGP 48506 in failing human myocardium. J Pharmacol Exp Ther. 277:1996;1579-1585.
8. Ukai T., Cheng C.P., Tachibana H., Igawa A., Zhang Z.S., Cheng H.J., Little W.C. Allopurinol enhances the contractile response to dobutamine and exercise in dogs with pacing-induced heart failure. Circulation. 103:2001;750-755.
9. Saavedra W.F., Paolocci N., St John M.E., Skaf M.W., Stewart G.C., Xie J.S., Harrison R.W., Zeichner J., Mudrick D., Marban E., Kas D.A., Hare J.M. Imbalance between xanthine oxidase and nitric oxide synthase signaling pathways underlies mechanoenergetic uncoupling in the failing heart. Circ Res. 90:2002;297-304.
10. Hoey B.M., Butler J., Halliwell B. On the specificity of allopurinol and oxypurinol as inhibitors of xanthine oxidase. A pulse radiolysis determination of rate constants for reaction of allopurinol and oxypurinol with hydroxyl radicals. Free Radic Res Commun. 4:1988;259-263.
11. Scholz H. Inotropic drugs and their mechanisms of action. J Am Coll Cardiol. 4:1984;389-397.
12. http://www.cardiome.com (available on 7/4/03).