Female Sex Steroid Hormones and Pregnancy Regulate Receptors for Calcitonin Gene-Related Peptide in Rat Mesenteric Arteries, but Not in Aorta

Biology of Reproduction

Volumn 70, Issue 4, 2004, Pages 1055-1062

  Yallampalli, Chandrasekhar ^a,e   Kondapaka, S B ^b   Lanlua, P ^c   Wimalawansa, S J ^d   Gangula, P R R ^a  

^a University of Texas Medical Branch School of Medicine   (United States)

^b NATIONAL CANCER INSTITUTE   (United States)

^c MAHIDOL UNIVERSITY   (Thailand)

^d ROBERT WOOD JOHNSON MEDICAL SCHOOL   (United States)

^e Medical Research Building ^*  (United States)

Author keywords

Estradiol; Polypeptide receptors; Pregnancy; Progesterone; Steroid hormones

Indexed keywords

CALCITONIN GENE RELATED PEPTIDE RECEPTOR; COMPLEMENTARY DNA; ESTRADIOL; IODINE 125; MESSENGER RNA; POLYPEPTIDE; PROGESTERONE; SEX HORMONE; STEROID;

ARTICLE; CONTROLLED STUDY; FEMALE; HORMONAL REGULATION; MESENTERIC ARTERY; NONHUMAN; NUCLEOTIDE SEQUENCE; PREGNANCY; PRIORITY JOURNAL; RAT; RECEPTOR DOWN REGULATION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; VASCULAR ENDOTHELIUM; VASCULAR RESISTANCE;

ANIMALS; AORTA; CALCITONIN GENE-RELATED PEPTIDE; DOWN-REGULATION; DRUG COMBINATIONS; ESTRADIOL; FEMALE; HORMONE ANTAGONISTS; INTRACELLULAR SIGNALING PEPTIDES AND PROTEINS; MEMBRANE PROTEINS; MESENTERIC ARTERIES; MIFEPRISTONE; OSMOLAR CONCENTRATION; OVARIECTOMY; PREGNANCY; PROGESTERONE; PROTEIN ISOFORMS; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, CALCITONIN; RECEPTORS, CALCITONIN GENE-RELATED PEPTIDE; RNA, MESSENGER; UP-REGULATION;

ANIMALIA;

EID: 1642335339     PISSN: 00063363     EISSN: None     Source Type: Journal    
DOI: 10.1095/biolreprod.103.022467     Document Type: Article

References (38)

1. Magness RR. Maternal cardiovascular and other physiologic responses to the endocrinology of pregnancy. In: Fuller B (ed.), Endocrinology of Pregnancy, Totowa, NJ: Humana Press; 1998:507-539.
2. Sladek SM, Magness RR, Conrad KP. Nitric oxide and pregnancy. Am J Physiol 1977; 272:R441-R463.
3. Vagnoni KE, Shaw CE, Phernetton TM, Meglin BM, Bird IM, Magness RR. Endothelial vasodilator production by uterine and systemic arteries. III. Ovarian and estrogen effects on NO synthase. Am J Physiol 1998; 275:H1845-H1856.
4. Lockitch G. Clinical biochemistry of pregnancy. Clin Lab Sci 1997; 34:67-139.
5. Gangula PRR, Supowit SC, Wimalawansa SJ, Zhao H, Hallman DM, Yallampalli C. Calcitonin gene-related peptide is a depressor in NG-nitro-L-arginine methyl ester-induced hypertension during pregnancy. Hypertension 1997; 29:248-253.
6. Gangula PRR, Wimalawansa SJ, Yallampalli C. Progesterone upregulates vasodilator effects of calcitonin gene-related peptide in NG-nitro-L-arginine methyl ester-induced hypertension. Am J Obstet Gynecol 1997; 176:894-900.
7. Gangula PR, Zhao H, Supowit SC, Wimalawansa SJ, DiPette DJ, Yallampalli C. Pregnancy and steroid hormones enhance the vasodilation responses to CGRP in rats. Am J Physiol 1999; 276:H284-H288.
8. Grewal M, Cuevas J, Chaudhuri G, Nathan L. Effects of calcitonin gene-related peptide on vascular resistance in rats: role of sex steroids. Am Physiol Soc 1999; 276:H2063-H2068.
9. Rosenfeld MG, Mermod JJ, Amara SG, Swanson LW, Swchenko PE, Rivier J, Vale WW, Evans RM. Production of a novel neuropeptide encoded by the calcitonin gene via tissue-specific RNA processing. Nature 1983; 304:129-135.
10. DiPette DJ, Schwarzenberg K, Kerr N, Holland OB. Dose-dependent systemic and regional hemodynamic effects of calcitonin gene-related peptide. Am J Med Sci 1989; 297:65-70.
11. McEwan J, Legon S, Wimalawansa SJ, Zaidi M, Dollery CT, MacIntyre I. Calcitonin gene-related peptide: a review of its biology and relevance to the cardiovascular system. In: Laragh JH, Brenner BM, Kaplan NM (eds.), Endocrine Mechanisms in Hypertension. New York: Raven Press; 1989:287-306.
12. Supowit SC, Zhao H, Hallman DM, Dipette DJ. Calcitonin gene-related peptide is a depressor of deoxycorticosterone-salt hypertension in the rat. Hypertension 1997; 29:945-950.
13. Gibson SJ, Polak MR, Bloom SR, Sabte IM, Mulderry PM, Evans RM, Rosenfeld MG. Calcitonin gene-related peptide immunoreactivity in the spinal cord of man and eight other species. J Neurosci 1984; 12:3101-3111.
14. Marti E, Gibson SJ, Polak MN, Facer P, Springall DR, Aswegen G, Aitchison M, Koltzenburg M. Ontogeny of peptide and amino-containing neurons in motor, sensory and autonomic regions of rat and human spinal cord, dorsal root ganglia and rat skin. J Comp Neurol 1987; 266:332-359.
15. Poyner DR, Taylor GM, Tomlinson AE, Richardson AG, Smith DM. Characterization of receptors for calcitonin gene-related peptide and adrenomedullin on the guinea pig vas deferens. Br J Pharmacol 1999; 126:1276-1282.
16. Tomlinson AE, Poyner DR. Multiple receptors for calcitonin gene-related peptide and amylin on guinea pig ileum and vas deferens. Br J Pharmacol 1996; 117:1362-1368.
17. Rorabaugh BR, Scofield MA, Smith DD, Jeffries WB, Abel PW. Functional calcitonin gene-related peptide subtype 2 receptors in porcine coronary arteries are identified as calcitonin gene-related peptide subtype 1 receptors by radioligand binding and reverse transcription-polymerase chain reaction. J Pharmacol Exp Ther 2001; 299:1086-1094.
18. McLatchie LM, Fraser NJ, Main MJ, Wise A, Brown J, Thompson N, Solari R, Lee MG, Foord SM. RAMPs regulate the transport and ligand specificity of the calcitonin receptor-like receptor. Nature 1998; 393:333-339.
19. Wimalawansa SJ, Gunasekera RD, Zhang F. Isolation, purification, and characterization of calcitonin gene-related peptide receptor. Peptides 1993; 14:691-699.
20. Morara S, Wimalawansa SJ, Rosina A. Monoclonal antibodies reveal expression of the CGRP receptor in Purkinje cells, interneurons and astrocytes of rat cerebellar cortex. Neuroreport 1998; 9:3755-3759.
21. Wimalawansa SJ. Isolation, purification and biochemical characterization of calcitonin gene-related peptide receptors. Ann N Y Acad Sci 1992; 657:70-87.
22. Wimalawansa SJ, El-Kholy AA. Comparative study of distribution and biochemical characterization of brain calcitonin gene-related peptide receptors in five different species. Neurosci 1993; 54:513-519.
23. Yallampalli C, Gangula PRR, Kondapaka S, Fang L, Wimalawansa SJ. Regulation of calcitonin gene-related peptide receptors in the rat uterus during pregnancy, labor and by progesterone. Biol Reprod 1999; 61:1023-1030.
24. Wimalawansa SJ. Calcitonin gene-related peptide and its receptors: molecular genetics, physiology, pathophysiology, and therapeutic potentials. Endocr Rev 1996; 17:533-585.
25. Chauhan M, Thota CS, Kondapaka S, Wimalawansa SJ, Yallampalli C. Evidence for the existence of a new receptor for CGRP, which is not CRLR. Peptides 2003; 24:65-71.
26. Fluhmann B, Lauber M, Lichtensteiger W, Fischer JA, Born W. Tissue-specific mRNA expression of a calcitonin receptor-like receptor during fetal and postnatal development. Brain Res 1997; 774:184-192.
27. Franco-Cereceda A, Rudehill A. Capsaicin-induced vasodilation of human coronary arteries in vitro is mediated by calcitonin gene-related peptide rather than substance P or neurokinin A. Acta Physiol Scand 1989; 136:575-580.
28. Miyauchi T, Tomobe Y, Ishikawa T, Goto K, Sugishita Y. Calcitonin gene-related peptide (CGRP) induces more potent vasorelaxation in the resistance portion than in the conduit portion of mesenteric arteries in humans. Peptides 1996; 17:877-879.
29. 8-37 and CGRP receptor desensitization. Biochem Biophys Res Commun 1990; 168:786-791.
30. Nuki C, Kawasaki H, Takasaki K, Wada A. Pharmacological characterization of presynaptic calcitonin gene-related peptide (CGRP) receptors on CGRP-containing vasodilator nerves in rat mesenteric resistance vessels. J Pharmacol Exp Ther 1994; 268:59-64.
31. Lanlua P, Kondapaka S, Gangula PRR, Wimalawansa SJ, Bukoski RD. Pregnancy and female steroid hormones increase calcitonin gene-related peptide-induced mesenteric vascular relaxation in rats. J Soc Gynecol Invest 2001; 81:359 (abstract).
32. Hayashi T, Fukuto JM, Ignarro LJ, Chaudhuri G. Basal release of nitric oxide from aortic rings is greater in female rabbits than in male rabbits: implications for atherosclerosis. Proc Natl Acad Sci U S A 1992; 89:11259-11263.
33. Crofton JT, Share L. Gonadal hormones modulate deoxycorticosterone-salt hypertension in male and female rats. Hypertension 1997; 29:494-499.
34. Rosenfeld CR, Cox BE, Roy T, Magness RR. Nitric oxide contributes to estrogen-induced vasodilation of the ovine uterine circulation. J Clin Invest 1996; 98:2158-2166.
35. Paredes-Carbajai MC, Juarez-Oropeza MA, Ortiz-Mendoza CM, Moscher D. Effects of acute and chronic estrogen treatment on vasomotor responses of aortic rings from ovariectomized rats. Life Sci 1995; 57:473-486.
36. + channels. Nature 1990; 344:770-773.
37. Gangula PR, Thota CS, Wimalawansa SJ, Bukoski RD, Yallampalli C. Mechanisms involved in calcitonin gene-related peptide-induced relaxation in pregnant rat uterine artery. Biol Reprod 2003; 69:1635-1641.
38. + channels of vascular smooth muscle cells via adenylate cyclase. Basic Res Cardiol 1995; 90:332-336.