Recent developments in the pathophysiology of cholestasis

Clinics in Liver Disease

Volumn 8, Issue 1, 2004, Pages 1-26

  Hutchins, Grant F ^a   Gollan, John L ^a  

^a UNIVERSITY OF NEBRASKA MEDICAL CENTER   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

CARRIER PROTEIN; CELL NUCLEUS RECEPTOR; CYCLIC AMP; FARNESOID X RECEPTOR; LIVER X RECEPTOR; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; PREGNANE X RECEPTOR; RETINOIC ACID RECEPTOR; RETINOID X RECEPTOR; STEROID RECEPTOR; TAUROCHOLIC ACID; TAUROURSODEOXYCHOLIC ACID; URSODEOXYCHOLIC ACID;

BILE; CHOLESTASIS; CLINICAL FEATURE; GENE EXPRESSION; GENETIC ANALYSIS; GENETIC TRAIT; GENETIC VARIABILITY; HUMAN; LIVER CELL; NONHUMAN; PATHOPHYSIOLOGY; REVIEW;

BILE; CHOLESTASIS; HUMANS; MEMBRANE TRANSPORT PROTEINS; RECEPTORS, CYTOPLASMIC AND NUCLEAR; TRANSCRIPTION FACTORS;

EID: 1642332310     PISSN: 10893261     EISSN: None     Source Type: Journal    
DOI: 10.1016/S1089-3261(03)00125-9     Document Type: Review

References (46)

1. Trauner M., Boyer J. Bile salt transporters: molecular characterization, function, and regulation. Physiol Rev. 83:2003;633-671.
2. Lewis J., Zimmerman H. Drug and chemical induced cholestasis. Clin Liver Dis. 3(3):1999;433-464.
3. Trauner M., Meier P., Boyer J. Molecular pathogenesis of cholestasis. N Engl J Med. 339(17):1998;1217-1227.
4. Jansen P. From classic bile physiology to cloned transporters [foreword]. Semin Liver Dis. 20:2000;245-250.
5. Berk P., Jansen P. Hepatic transporters, hepatic transport, and its diseases. Semin Liver Dis. 20:2000;247-408.
6. Meier P., Stieger B. Bile salt transporters. Ann Rev Physiol. 64:2002;635-661.
7. Wolkoff A., Cohen D. Bile acid regulation of hepatocyte physiology. I. Hepatocyte transport of bile acids. Am J Physiol Gastrointest Liver Physiol. 284:2003;G175-G179.
8. Hagenbuch B., Meier P. Sinusoidal (basolateral) bile salt uptake systems of hepatocytes. Semin Liver Dis. 16:1996;129-136.
9. Kullack-Ublick G., Stieger B., Hagenbuch B., Meier P. Hepatic transport of bile salts. Semin Liver Dis. 20:2000;273-292.
10. Kipp H., Arias I. Trafficking of canalicular ABC transporters in hepatocytes. Ann Rev Physiol. 64:2002;595-608.
11. Hooiveld G., Van Montfoort J., Meijer D., Muller M. Function and regulation of ATP-binding cassette transport proteins involved in hepatobiliary transport. Eur J Pharm Sci. 12:2001;525-543.
12. Chiang J. Bile acid regulation of gene expression: roles of nuclear hormone receptors. Endocr Rev. 23(4):2002;443-463.
13. Goodwin B., Kliewer S. Nuclear receptors. I. Nuclear receptors and bile acid homeostasis. Am J Physiol Gastrointest Liver Physiol. 282:2002;G926-G931.
14. Hofmann A. The continuing importance of bile acids in liver and intestinal disease. Arch Intern Med. 159:1999;2647-2658.
15. Chiang J. Bile acid regulation of hepatic physiology. III. Bile acids and nuclear receptors. Am J Physiol Gastrointest Liver Physiol. 284:2003;G349-G356.
16. Karpen S. Nuclear receptor regulation of hepatic function. J Hepatol. 36:2002;832-850.
17. Chignard N., Mergey M., Veissiere D., Parc R., Capeau J., Poupon R.et al. Bile acid transport and regulating functions in the human biliary epithelium. Hepatology. 33:2001;496-503.
18. Mangelsdorf D., Evans R. The RXR heterodimers and orphan receptors. Cell. 83:1995;841-850.
19. Chawla A., Repa J., Evans R., Mangelsdorf D. Nuclear receptors and lipid physiology: opening the X-files. Science. 294:2001;1866-1870.
20. Lee Y., Dell H., Dowhan D., Hadzopoulou-Cladaras M., Moore D. The orphan nuclear receptor SHP inhibits hepatocyte nuclear factor 4 and retinoid X receptor transactivation: two mechanisms for repression. Mol Cell Biol. 20:2000;187-195.
21. Kast H., Goodwin B., Tarr P., Jones S., Anisfeld A., Stoltz C.et al. Regulation of multidrug resistance-associated protein 2 (ABCC2) by the nuclear receptors pregnane X receptor, farnesoid X-activated receptor, and constitutive androstane receptor. J Biol Chem. 277:2002;2908-2915.
22. Plass J., Mol O., Heegsma J., Geuken M., Faber K., Jansen P.et al. Farnesoid X receptor and bile salts are involved in transcriptional regulation of the gene encoding the human bile salt export pump. Hepatology. 35:2002;589-596.
23. Synold T., Dussault I., Forman B. The orphan nuclear receptor SXR coordinately regulates drug metabolism and efflux. Nat Med. 7:2001;584-590.
24. Staudinger J., Goodwin B., Jones S., Hawkins-Brown D., MacKenzie K., LaTour A.et al. The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity. Proc Natl Acad Sci U S A. 98:2001;3369-3374.
25. Suzuki H., Sugiyama Y. Transport of drugs across the hepatic sinusoidal membrane: sinusoidal drug influx and efflux in the liver. Semin Liver Dis. 20:2000;251-263.
26. Gupta S., Stravitz R., Dent P., Hylemon P. Down-regulation of cholesterol 7α-hydroxylase (CYP7A1) gene expression by bile acids in primary rat hepatocytes is mediated by the c-Jun N-terminal kinase pathway. J Biol Chem. 276:2001;15816-15822.
27. Jung D., Fried M., Kullak-Ublick G. Human apical sodium-dependent bile salt transporter gene (SLC10A2) is regulated by the peroxisome proliferator-activated receptor alpha. J Biol Chem. 277:2002;30559-30566.
28. Hayhurst G., Lee Y., Lambert G., Ward J., Gonzalez F. Hepatocyte nuclear factor 4α (nuclear receptor 2A1) is essential for maintenance of hepatic gene expression and lipid homeostasis. Mol Cell Biol. 21:2001;1393-1403.
29. Fickert P., Zollner G., Fuchsbichler A., Stumptner C., Pojer C., Zenz R.et al. Effects of ursodeoxycholic and cholic acid feeding on hepatocellular transporter expression in mouse liver. Gastroenterology. 121:2001;170-183.
30. Rost D., Kartenbeck J., Keppler D. Changes in the localization of the rat canalicular conjugate export pump Mrp2 in phalloidin-induced cholestasis. Hepatology. 29:1999;814-821.
31. Jansen P., Muller M., Sturm E. Genes and cholestasis. Hepatology. 34:2001;1067-1074.
32. Lee J., Boyer J. Molecular alterations in hepatocyte transport mechanisms in acquired cholestatic liver disorders. Semin Liver Dis. 20:2000;373-384.
33. Lucena J., Herrero J., Quiroga J., Sangro B., Garcias-Foncillas J., Zabalegui N.et al. A multidrug resistance 3 gene mutation causing cholelithiasis, cholestasis of pregnancy, and adulthood biliary cirrhosis. Gastroenterology. 124:2003;1037-1042.
34. Jansen P., Muller M. The molecular genetics of familial intrahepatic cholestasis. Gut. 47:2000;1-5.
35. Pawlikowska L., Ottenhoff R., Looije N., Eppens E., Knisely A., Bull L. et al. F1C1 mutant mice have a defect in the regulation of intestinal bile salt absorption [abstract]. Hepatology. 34:2001;240A.
36. Bull L., Van Eijk M., Pawlikowska L., DeYoung J., Juijn J., Liao M.et al. A gene encoding a P-type ATPase mutated in two forms of hereditary cholestasis. Nat Genet. 18:1998;219-224.
37. Strautnieks S., Bull L., Knisely A., Kocoshis S., Dahl N., Arnell H.et al. A gene encoding a liver-specific ABC transporter is mutated in progressive familial intrahepatic cholestasis. Nat Genet. 20:1998;233-238.
38. Deleuze J., Jacquemin E., Dubuisson C., Crestell D., Dumont M., Erlinger S.et al. Defect on multidrug-resistance 3 gene expression in a subtype of progressive familial intrahepatic cholestasis. Hepatology. 23:1996;904-908.
39. DeVree J., Ottenhoff R., Bosma P., Smith A., Aten J., Deleuze J.et al. Mutations in the MDR3 gene cause progressive familial intrahepatic cholestasis. Proc Natl Acad Sci U S A. 95:1998;282-287.
40. Rosmorduc O., Hermelin B., Boelle P., Parc R., Taboury J., Poupon R. ABCB4 gene mutation-associated cholelithiasis in adults. Gastroenterology. 125:2003;452-459.
41. Kartenbeck J., Leuschner U., Mayer R., Keppler D. Absence of the canalicular isoform of the MRP gene-encoded conjugate export pump from the hepatocytes in Dubin-Johnson syndrome. Hepatology. 23:1996;1061-1066.
42. Paulusma C., Kool M., Bosma P., Scheffer G., TerBorg F., Scheper R.et al. A mutation in the human canalicular multispecific organic anion transporter gene causes the Dubin-Johnson syndrome. Hepatology. 25:1997;1539-1542.
43. Wada M., Toh S., Taniguchi K., Nakamura T., Uchiumi T., Kohno K.et al. Mutations in the canalicular multispecific organic anion transporter (cMOAT) gene, a novel ABC transporter, in patients with hyperbilirubinemia/ Dubin-Johnson syndrome. Hum Mol Genet. 7:1998;203-207.
44. +/bile acid cotransporter in extrahepatic cholestasis. Gastroenterology. 110:1996;199-209.
45. Shneider B., Fox V., Schwarz K., Watson C., Ananthanarayanan M., Thevananther S.et al. Hepatic basolateral sodium-dependent-bile acid transporter expression in two unusual cases of hypercholanemia and in extrahepatic biliary atresia. Hepatology. 25:1997;1176-1183.
46. Zollner G., Fickert P., Silbert D., Fuchsbichler A., Marschall H., Zatloukal K.et al. Adaptive changes in hepatobiliary transporter expression in primary biliary cirrhosis. J Hepatol. 38:2003;717-727.