Protective effects of the angiotensin II type I (AT1) receptor blockade in low-renin deoxycorticosterone acetate (DOCA)-treated spontaneously hypertensive rats

Clinical Science

Volumn 106, Issue 3, 2004, Pages 251-259

  Chamorro, Virginia ^a   Wangensteen, Rosemary ^a   Sainz, Juan ^a   Duarte, Juan ^b   O'Valle, Francisco ^c   Osuna, Antonio ^c   Vargas, Félix ^a  

^a UNIVERSITY OF GRANADA   (Spain)

^b UNIVERSITY OF GRANADA   (Spain)

^c UNIVERSITY OF GRANADA   (Spain)

Author keywords

Deoxycorticosterone acetate (DOCA); Hypertension; Losartan; Renal injury; Spontaneously hypertensive rat

Indexed keywords

ANGIOTENSIN RECEPTOR ANTAGONIST; DEOXYCORTICOSTERONE ACETATE; ISOPROSTANE; LOSARTAN; MALONALDEHYDE; RENIN;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANTIHYPERTENSIVE ACTIVITY; ARTICLE; BLOOD PRESSURE; CHEMICAL ANALYSIS; CONTROLLED STUDY; HEART PROTECTION; HEART VENTRICLE HYPERTROPHY; HISTOPATHOLOGY; HYPERTENSION; KIDNEY CORTEX; KIDNEY INJURY; KIDNEY MASS; MALE; NONHUMAN; OXIDATIVE STRESS; PRIORITY JOURNAL; PROTEINURIA; RAT; SYSTOLE;

ANGIOTENSIN II; ANGIOTENSIN II TYPE 1 RECEPTOR BLOCKERS; ANIMALS; ANTIHYPERTENSIVE AGENTS; CARDIOMEGALY; DESOXYCORTICOSTERONE; ENDOTHELINS; HYPERTENSION; ISOPROSTANES; KIDNEY; LOSARTAN; MALE; MALONDIALDEHYDE; PROTEINURIA; RATS; RATS, INBRED SHR; RENIN;

EID: 1642329725     PISSN: 01435221     EISSN: None     Source Type: Journal    
DOI: 10.1042/CS20030299     Document Type: Article

References (37)

1. Trippodo, N. and Frolich, E. (1981) Similarities of genetic (spontaneous) hypertension: man and rat. Circ. Res. 48, 309-319
2. Mizumo, K., Tani, M., Hashimoto, S. et al. (1992) Effects of losartan, a nonpeptide angiotensin II receptor antagonist, on cardiac hypertrophy and the tissue angiotensin II content in spontaneously hypertensive rats. Life. Sci. 51, 367-374
3. 1 blockade. Kidney Int. 62, 914-921
4. Morgan, H. E. and Baker, K. M. (1991) Cardiac hypertrophy. Mechanical, neural and endocrine dependence. Circulation 83, 13-25
5. Mezzano, S. A., Ruiz-Ortega, M. and Egido, J. (2001) Angiotensin II and renal fibrosis. Hypertension 38, 635-638
6. Karam, H., Heudes, D., Bruneval, P. et al. (1996) Endothelin antagonism in end-organ damage of spontaneously hypertensive rats. Comparison with angiotensin-converting enzyme inhibition and calcium antagonism. Hypertension 28, 379-385
7. Suzuki, H., Swei, A., Zweifach, B. W. and Schmid-Schönbein, G. W. (1995) In vivo evidence for microvascular oxidative stress in spontaneously hypertensive rats: hydroethidine microfluorography. Hypertension 25, 1083-1089
8. Duarte, J., Pérez-Palencia, R., Vargas, F. et al. (2001) Antihypertensive effects of the flavonoid quercetin in spontaneously hypertensive rats. Br. J. Pharmacol. 133, 117-124
9. Miyamoto, Y., Akaike, T., Yoshida, M., Goto, S., Horie, H. and Maeda, H. (1996) Potentiation of nitric oxide-mediated vasorelaxation by xanthine oxidase inhibitors. Proc. Soc. Exp. Biol. Med. 211, 366-373
10. 2α. Hypertension 33, 424-428
11. Romero, J. C. and Reckelhoff, J. F. (1999) Role of angiotensin and oxidative stress in essential hypertension. Hypertension 34, 943-949
12. 2α with different pressor dependencies in rats. Hypertension 39, 149-154
13. Roberts, L. J. and Morrow, J. D. (1997) The generation and actions of isoprostanes. Biochim. Biophys. Acta 1345, 121-135
14. 2α, in the rat. J. Clin. Invest. 90, 136-141
15. Kohno, M., Horio, T., Ikeda, M. et al. (1992) Angiotensin II stimulates endothelin-1 secretion in cultured rat mesangial cells. Kidney Int. 42, 860-866
16. 2-isoprostane, on endothelin-1 release. J. Cardiovasc. Pharmacol. 26, S51-S52
17. Pryor, W. A. and Squadrito, G. L. (1995) The chemistry of peroxynitrite: a product from the reaction of nitric oxide with superoxide. Am. J. Physiol. 268, L699-L772
18. De Gracia, M. C., Osuna, A., O' Valle, F. et al. (2000) Deoxicorticosterone suppresses the effects of losartan in nitric oxide-deficient hypertensive rats. J. Am. Soc. Nephrol. 11, 1995-2000
19. Fujita, H., Takeda, K., Miki, S. et al. (1997) Chronic angiotensin blockade with candesartan cilexetil in DOCA-salt hypertensive rats reduces cardiac hypertrophy and coronary resistance without affecting blood pressure. Hypertens. Res. 20, 263-267
20. Kim, S., Ohta, K., Hamaguchi, A. et al. (1994) Role of angiotensin II in renal injury of deoxycorticosterone acetate-salt hypertensive rats. Hypertension 24, 195-204
21. Esterbauer, H. and Cheeseman, K. H. (1990) Determination of aldehydic lipid peroxidation product: malonaldehyde and 4-hydroxynonenal. Methods Enzymol. 186, 407-421
22. Granger, D. L., Taintor, R. R., Boockvar, K. S. and Hibbs, J. B. (1996) Measurement of nitrate and nitrite in biological samples using nitrate reductase and Gries reaction. Methods Enzymol. 268, 142-151
23. Bradford, M. M. (1976) A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal. Biochem. 72, 248-254
24. Kline, R. L. and Liu, F. (1994) Modification of pressure natriuresis by long-term losartan in spontaneously hypertensive rats. Hypertension 24, 467-473
25. Millatt, L. J., Abdel-Rahman, E. M. and Siragy, H. M. (1999) Angiotensin II and nitric oxide: a question of balance. Reg. Pept. 81, 1-10
26. Reference deleted
27. Linz, W., Scholkens, B. A. and Ganten, D. (1989) Converting enzyme inhibition specifically prevents the development and induces the regression of cardiac hypertrophy in rats. Clin. Exp. Hypertens. 11, 1325-1350
28. Funder, J. (2001) Mineralocorticoids and cardiac fibrosis: the decade in review. Clin. Exp. Pharmacol. Physiol. 28, 1002-1006
29. Guarda, E., Katwa, L. C., Myers, P. R., Tyagi, S. C. and Weber, K. T. (1993) Effects of endothelins on collagen turnover in cardiac fibroblasts. Cardiovasc. Res. 27, 2130-2134
30. Rodríguez-Gómez, I., Wangensteen, R., Atucha, N. M. et al. (2003) Effects of omapatrilat on blood pressure and renal injury in L-NAME and L-NAME plus DOCA-treated rats. Am. J. Hypertens. 16, 33-38
31. Dworkin, L. D. and Feiner, H. D. (1986) Glomerular injury in uninephrectomized spontaneously hypertensive rats. A consequence of glomerular capillary hypertension. J. Clin. Invest. 77, 797-809
32. Feld, L. J., Van Liew, J. B., Galaske, R. G. and Boylan, J. W. (1977) Selectivity of renal injury and proteinuria in the spontaneously hypertensive rat. Kidney Int. 12, 332-343
33. 1 receptor. Hypertension 39, 116-121
34. Simonson, M. S. (1993) Endothelins: multifunctional renal peptides. Physiol. Rev. 73, 375-411
35. Kitamura, K., Tanaka, T., Kato, J., Eto, T. and Tanaka, K. (1989) Regional distribution of immunoreactive endothelin in porcine tissue: abundance in inner medulla of kidney. Biochem. Biophys. Res. Commun. 161, 348-352
36. Abassi, Z. A., Klein, H., Golomb, E., and Keiser, H. R. (1993) Regulation of the urinary excretion of endothelin in the rat. Am. J. Hypertens. 6, 453-457
37. Hughes, A. K., Cline, R. C. and Kohan, D. E. (1992) Alterations in renal endothelin-1 production in the spontaneously hypertensive rat. Hypertension 20, 666-673