Cutaneous necrosis induced by acenocoumarol

Journal of the European Academy of Dermatology and Venereology

Volumn 18, Issue 2, 2004, Pages 211-215

  Valdivielso, M ^a   Longo, I ^a   Lecona, M ^a   Lazaro P ^a  

^a HOSPITAL GENERAL UNIVERSITARIO GREGORIO MARAÑÓN   (Spain)

Author keywords

Oral anticoagulant therapy; Protein C; Skin necrosis; Vasculitis

Indexed keywords

ACENOCOUMAROL; ANTICOAGULANT AGENT; GLYCOPROTEIN; LOW MOLECULAR WEIGHT HEPARIN; PROTEIN C; PROTEIN S; VERAPAMIL; VITAMIN K GROUP;

AGED; CASE REPORT; CLINICAL FEATURE; DEEP VEIN THROMBOSIS; ECCHYMOSIS; ERYTHROCYTE; EXTRAVASATION; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LEUKOCYTE COUNT; OBESITY; PRIORITY JOURNAL; REVIEW; SKIN BIOPSY; SKIN NECROSIS; THROMBOCYTE COUNT; VASCULITIS;

ACENOCOUMAROL; ADMINISTRATION, ORAL; AGED; AGED, 80 AND OVER; ANTICOAGULANTS; FEMALE; HUMANS; NECROSIS; PROTEIN C DEFICIENCY; SKIN; VASCULITIS, HYPERSENSITIVITY;

EID: 1642317048     PISSN: 09269959     EISSN: None     Source Type: Journal    
DOI: 10.1111/j.1468-3083.2004.00735.x     Document Type: Review

References (26)

1. Verhagen H. Local haemorrhage and necrosis of the skin and underlying tissues, during anti-coagulant therapy with dicumarol or dicumacyl. Acta Med Scand 1954; 148: 453-462.
2. Stern R, Wintroub B. Cutaneous reactions to drugs. In: Freedberg IM, Eisen AZ, Wolff K, eds. Fitzpatrick's Dermatology in General Medicine, 5th edn. McGraw-Hill, New York, 1999; 873-890.
3. Comp P, Elrod J, Karzenski S. Warfarin-induced skin necrosis. Semin Thromb Hemost 1990; 16: 293-297.
4. Eby CS. Warfarin-induced skin necrosis. Hematol Oncol Clin North Am 1993; 7: 1291-1300.
5. DeFranzo AJ, Marasco P, Argenta LC. Warfarin induced necrosis of the skin. Ann Plast Surg 1995; 34: 203-208.
6. Ad-El DD, Meirouitz A, Weirberg A, Kogan L, Arieli D, Neilman A, Linton D. Warfarin skin necrosis: Local and systemic factors. Br J Plast Surg 2000; 53: 624-626.
7. Brennan M, Morgan HJ, George A. Deep venous thrombosis with localized skin necrosis. J Tenn Med Assoc 1986; 79: 210.
8. Humphries JE, Gardner JH, Connelly JE. Warfarin skin necrosis: Recurrence in the absence of anticoagulant therapy. Am J Hematol 1991; 37: 197-200.
9. Goldberg SL, Orthner CL, Yalisove BL, Elgart ML, Kessler CM. Skin necrosis following prolonged administration of coumarin in a patient with inherited protein S deficiency. Am J Hematol 1991; 38: 64-66.
10. Boerger LM, Morris PC, Thurnau GR, Esmon CT, Comp PC. Oral contraceptives and gender affect protein S status. Blood 1987; 69: 692-694.
11. McGehee WG, Klotz TA, Epstein DJ, Rapaport SI. Coumarin necrosis associated with hereditary protein C deficiency. Ann Intern Med 1984; 100: 59-60.
12. Rose VL, Kwaan HC, Willianson K, Hoppensteadt D, Walenga J, Fareed J. Protein C antigen and warfarin necrosis. Am J Clin Pathol 1986; 86: 653-655.
13. Honigsmann H, Wolff K. Purpura fulminans. Intravascular coagulation vasculitis. In: Wolff K, Winkelmann RK, eds. Vasculitis. Lloyd-Luke Medical Books, London, 1980; 218-277.
14. Milench J, Sherman L, Broze G. Absence of thrombosis in subjects with heterozygous protein C deficiency. N Engl J Med 1987; 317: 991-996.
15. Lopez Estebaranz JL, Ortiz J, Lauzurika E, Romero G, Iglesias L. Purpura fulminans: A propósito de dos casos. Implicaciones etiopatogénicas del déficit de proteína C. Actas Dermo-Sif 1992; 83: 640-645.
16. Essex DW, Wynn SS, Jin DK. Late-onset warfarin-induced skin necrosis: Case report and review of the literature. Am J Hematol 1998; 57: 233-237.
17. Bauer K. Hypercoagulability: A new cofactor in the protein C anticoagulant pathway. N Engl J Med 1994; 330: 566-567.
18. Moreb J, Kitchens CS. Acquired functional protein S deficiency, cerebral venous thrombosis, and coumarin skin necrosis in association with antiphospholipid syndrome: Report of two cases. Am J Med 1989; 87: 207-210.
19. Grimaudo V, Gueissaz F, Hauert J, Sarraji A, Kruithof EKO, Bachmann F. Necrosis of skin induced by coumarin in a patient deficient in protein S. Br Med J (Clin Res) 1989; 298: 233-234.
20. Kiehl R, Hellstern P, Wenzel E. Hereditary antithrombin III deficiency and atypical localization of coumarin necrosis. Thromb Res 1987; 45: 191-193.
21. Cole MS, Minifee PK, Wolma FJ. Coumarin necrosis-a review of the literature. Surgery 1988; 103: 271-277.
22. Friedenberg WR, West M, Miech DJ, Mazza SS. Atypical purpura fulminans with benign monoclonal gammophathy. Arch Dermatol 1978; 114: 578-580.
23. Yang Y, Algazy KM. Warfarin-induced skin necrosis in a patient with a mutation of the prothrombin gene. Am J Hematol 1999; 61: 218-219.
24. Hofmann V, Frick PG. Repeated occurrence of skin necrosis twice following coumarin intake and subsequently during decrease of vitamin K dependent coagulation factors associated with cholestasis. Thromb Haemost 1982; 48: 245-246.
25. Davis CE, Wiley WB, Faulconer RJ. Necrosis of the female breast complicating oral anticoagulant treatment. Ann Surg 1972; 175: 647.
26. Adcock DM, Hicks MJ. Dermatopathology of skin necrosis associated with purpura fulminans. Semin Thromb Hemost 1990; 16: 283-292.