Albumin dialysis: A new therapeutic strategy for intoxication from protein-bound drugs

Intensive Care Medicine

Volumn 30, Issue 3, 2004, Pages 496-501

  Sen, Sambit ^a   Ytrebø, Lars M ^b   Rose, Christopher ^c   Fuskevaag, Ole Martin ^b   Davies, Nathan A ^a   Nedredal, Geir I ^b   Williams, Roger ^a   Revhaug, Arthur ^b   Jalan, Rajiv ^a  

^a Institute of Hepatology   (United Kingdom)

^b UNIVERSITY HOSPITAL OF NORTH NORWAY   (Norway)

^c MAX DELBRÜCK CENTER FOR MOLECULAR MEDICINE   (Germany)

Author keywords

Adsorption; Albumin dialysis; Charcoal; Fentanyl; Midazolam

Indexed keywords

ADSORBENT; ALBUMIN; FENTANYL; FENTANYL DERIVATIVE; GLYCOPROTEIN; MIDAZOLAM; MIDAZOLAM MALEATE;

ADSORPTION; ALBUMIN DIALYSIS; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; ASSISTED CIRCULATION; CONTROLLED STUDY; DIALYSATE LEVEL; DIALYSIS; DRUG BINDING; DRUG BLOOD LEVEL; DRUG CLEARANCE; DRUG PROTEIN BINDING; DRUG SOLUBILITY; EXPERIMENTAL THERAPY; HEMODIALYSIS; HEMOFILTRATION; INTOXICATION; LIVER FAILURE; MORBIDITY; MORTALITY; NONHUMAN; UNIVERSITY HOSPITAL;

ANESTHETICS, INTRAVENOUS; ANIMALS; FEMALE; FENTANYL; LINEAR MODELS; LIVER FAILURE, ACUTE; MIDAZOLAM; OROSOMUCOID; PROTEIN BINDING; SERUM ALBUMIN; SORPTION DETOXIFICATION; SWINE;

EID: 1642307986     PISSN: 03424642     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00134-003-2141-0     Document Type: Article

References (14)

1. Stange J, Ramlow W, Mitzner S, Schmidt R, Klinkmann H (1993) Dialysis against a recycled albumin solution enables the removal of albumin-bound toxins. Artif Organs 17:809-813
2. Stange J, Mitzner S, Ramlow W, Gliesche T, Hickstein H, Schmidt R (1993) A new procedure for the removal of protein bound drugs and toxins. Asaio J 39:M621-625
3. Stange J, Mitzner S (1996) A carrier-mediated transport of toxins in a hybrid membrane. Safety barrier between a patients blood and a bioartificial liver. Int J Artif Organs 19:677-691
4. Sen S, Ratnaraj N, Davies NA, Mookerjee RP, Cooper CE, Patsalos PN, Williams R, Jalan R (2003) Treatment of phenytoin toxicity by the Molecular Adsorbents Recirculating System (MARS). Epilepsia 44:265-267
5. Physicians' Desk Reference (2002) 56th edn. Medical Economics, Montvale, N.J.
6. Ytrebo LM, Nedredal GI, Korvald C, Holm Nielsen OJ, Ingebrigtsen T, Romner B, Aarbakke J, Revhaug A (2001) Renal elimination of protein S-100 beta in pigs with acute encephalopathy. Scand J Clin Lab Invest 61:217-225
7. Ytrebo LM, Nedredal GI, Langbakk B, Revhaug A (2002) An experimental large animal model for the assessment of bioartificial liver support systems in fulminant hepatic failure. Scand J Gastroenterol 37:1077-1088
8. Lapatto-Reiniluoto O, Kivisto KT, Neuvonen PJ (1999) Effect of activated charcoal alone or given after gastric lavage in reducing the absorption of diazepam, ibuprofen and citalopram. Br J Clin Pharmacol 48:148-153
9. el-Sayed YM, Hasan MM (1990) Enhancement of morphine clearance following intravenous administration by oral activated charcoal in rabbits. J Pharm Pharmacol 42:538-541
10. Torrente A de, Rumack BH, Blair DT, Anderson RJ (1979) Fixed-bed uncoated charcoal hemoperfusion in the treatment of intoxications: animal and patient studies. Nephron 24:71-77
11. Koffler A, Bernstein M, LaSette A, Massry SG (1978) Fixed-bed charcoal hemoperfusion. Treatment of drug overdose. Arch Intern Med 138:1691-1694
12. Wiesner G, Taeger K, Peter K (1996) Serum protein binding of fentanyl. The effect of postoperative acute phase reaction with elevated alpha 1-acid glycoprotein and methodologic problems in determination by equilibrium dialysis. Anaesthesist 45:323-329
13. Lehmann KA, Schmitz KF, Daub D (1983) Disposition of fentanyl in human blood. Anaesthesist 32:329-334
14. Litovitz TL, Klein-Schwartz W, Rodgers GC Jr, Cobaugh DJ, Youniss J, Omslaer JC, May ME, Woolf AD, Benson BE (2002) 2001 Annual report of the American Association of Poison Control Centers Toxic Exposure Surveillance System. Am J Emerg Med 20:391-452