Serpin mechanism of hepatitis C virus nonstructural 3 (NS3) protease inhibition: Induced fit as a mechanism for narrow specificity

Journal of Biological Chemistry

Volumn 279, Issue 11, 2004, Pages 10222-10227

  Richer, Martin J ^a   Juliano, Luiz ^b   Hashimoto, Carl ^c   Jean, François ^a  

^a UNIVERSITY OF BRITISH COLUMBIA   (Canada)

^b FEDERAL UNIVERSITY OF SÃO PAULO   (Brazil)

^c YALE UNIVERSITY SCHOOL OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

BIOCHEMISTRY; CATALYSIS; PLASTICITY; VIRUSES;

PROTEOLYSIS; PROTEOLYTIC MATURATION;

ENZYME INHIBITION;

SERINE PROTEINASE INHIBITOR;

ARTICLE; CELL MATURATION; COMPLEX FORMATION; CYTOARCHITECTURE; DROSOPHILA; ENZYME ACTIVE SITE; ENZYME INHIBITION; GENE DISRUPTION; HEPATITIS C VIRUS; MACROMOLECULE; NONHUMAN; PRIORITY JOURNAL; PROTEIN DEGRADATION; PROTEINASE INHIBITION; STRUCTURAL GENE; TISSUE SPECIFICITY; VIRUS MORPHOLOGY;

AMINO ACID SEQUENCE; ANIMALS; BINDING SITES; CATALYTIC DOMAIN; CHYMOTRYPSIN; DOSE-RESPONSE RELATIONSHIP, DRUG; DROSOPHILA; ELECTROPHORESIS, POLYACRYLAMIDE GEL; KINETICS; MODELS, MOLECULAR; MOLECULAR SEQUENCE DATA; PEPTIDES; PROTEASE INHIBITORS; PROTEIN BINDING; PROTEIN STRUCTURE, TERTIARY; RECOMBINANT PROTEINS; SERPINS; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION; SUBSTRATE SPECIFICITY; TIME FACTORS; TRANSCRIPTION FACTORS; VIRAL NONSTRUCTURAL PROTEINS;

FLAVIVIRIDAE; HEPATITIS C VIRUS; WEST NILE VIRUS;

EID: 1642276021     PISSN: 00219258     EISSN: None     Source Type: Journal    
DOI: 10.1074/jbc.M313852200     Document Type: Article

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