Apparent primary follicle-stimulating hormone deficiency is a rare cause of treatable male infertility

Fertility and Sterility

Volumn 81, Issue 3, 2004, Pages 693-696

  Giltay, Jacques C ^a   Deege, Marjolein ^a   Blankenstein, Rien A ^a   Kastrop, Peter M M ^a   Wijmenga, Cisca ^a   Lock, Tycho T W T ^a  

^a UNIVERSITY MEDICAL CENTER UTRECHT   (Netherlands)

Author keywords

FSH deficiency; FSH treatment; Male infertility; Oligoteratozoospermia

Indexed keywords

FOLLITROPIN; GONADORELIN; LUTEINIZING HORMONE; RECOMBINANT FOLLITROPIN;

ABORTION; ADULT; ANAMNESIS; ARTICLE; AZOOSPERMIA; CASE REPORT; CHROMOSOME ANALYSIS; COMPARATIVE STUDY; DISEASE SEVERITY; DRUG EFFECT; GENE MUTATION; GENE SEQUENCE; GENOME ANALYSIS; HORMONE DEFICIENCY; HUMAN; KARYOTYPING; LABORATORY TEST; MALE; MALE INFERTILITY; MOLECULAR BIOLOGY; PATIENT; PHENOTYPE; PHYSICAL EXAMINATION; PREGNANCY; PRIORITY JOURNAL; PROVOCATION TEST; SEQUENCE ANALYSIS; UNIVERSITY HOSPITAL; Y CHROMOSOME;

ADULT; DNA; FEMALE; FOLLICLE STIMULATING HORMONE; FOLLICLE STIMULATING HORMONE, BETA SUBUNIT; HORMONES; HUMANS; INFERTILITY, MALE; MALE; METABOLISM, INBORN ERRORS; OLIGOSPERMIA; PREGNANCY; TREATMENT OUTCOME;

EID: 1642264903     PISSN: 00150282     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.fertnstert.2003.07.030     Document Type: Article

References (14)

1. Van Assche E., Bonduelle M., Tournaye H., Joris H., Verheyen G., Devroey P., et al. Cytogenetics of infertile men. Hum Reprod. 11:1996;1-26.
2. Silveira L.F., MacColl G.S., Bouloux P.M. Hypogonadotropic hypogonadism. Semin Reprod Med. 20:2002;327-338.
3. Tapanainen J.S., Aittomaki K., Min J., Vaskivuo T., Huhtaniemi I.T. Men homozygous for an inactivating mutation of the follicle-stimulating hormone (FSH) receptor gene present variable suppression of spermatogenesis and fertility. Nat Genet. 15:1997;205-206.
4. Kumar T.R., Wang Y., Lu N., Matzuk M.M. Follicle stimulating hormone is required for ovarian follicle maturation but not male fertility. Nat Genet. 15:1997;201-204.
5. Hägg E., Tollin C., Bergman B. Isolated FSH deficiency in a male. A case report. Scand J Urol Nephrol. 12:1978;287-289.
6. McConnon J., Killinger D., Gracey W., Ghany F. Clomiphene in treatment of male infertility due to isolated follicle-stimulating-hormone deficiency. Lancet. 2:1979;525-526.
7. Mozaffarian G., Higley M., Paulsen C. Clinical studies in an adult male patient with "isolated follicle stimulating hormone (FSH) deficiency" J Androl. 4:1983;393-398.
8. Al-Ansari A., Khalil T., Kelani Y., Mortimer C.H. Isolated follicle-stimulating hormone deficiency in men successful long-term gonadotrophin therapy. Fertil Steril. 42:1984;618-626.
9. Mantovani G., Borgato S., Beck-Peccoz P., Romoli R., Borretta G., Persani L. Isolated follicle-stimulating hormone (FSH) deficiency in a young man with normal virilization who did not have mutations in the FSHbeta gene. Fertil Steril. 79:2003;434-436.
10. World Health Organization. WHO laboratory manual for the examination of human semen and sperm-cervical mucus interaction. 4th edition:1999;Cambridge University Press, New York.
11. Pierce J.G. The subunits of pituitary thyrotropin-their relationship to other glycoprotein hormones. Eli Lilly lecture. Endocrinology. 89:1971;1331-1344.
12. Lindstedt G., Nyström E., Matthews C., Ernest I., Janson P.O., Chatterjee K. Follitropin (FSH) deficiency in an infertile male due to FSHβ gene mutation. A syndrome of normal puberty and virilization but underdeveloped testicles with azoospermia, low FSH but high lutropin and normal serum testosterone concentrations. Clin Chem Lab Med. 36:1998;663-665.
13. Phillip M., Arbelle J., Segev Y., Parvari R. Male hypogonadism due to a mutation in the gene for the β-subunit of follicle-stimulating hormone. N Engl J Med. 338:1998;1729-1732.
14. Keene J., Matzuk M., Otani T., Fauser B.C., Galway A.B., Hsueh A.J., Boime I. Expression of biologically active human follitropin in Chinese hamster ovary cells. J Biol Chem. 264:1989;4769-4775.