Induction of intracellular cytokine production in human monocytes/macrophages stimulated with ligands of pattern recognition receptors

Inflammation Research

Volumn 53, Issue 3, 2004, Pages 100-106

  Mytar, B ^a   Gawlicka, M ^a   Szatanek, R ^a   Woloszyn M ^a   Ruggiero, I ^a   Piekarska, B ^b   Zembala, M ^a  

^a JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

^b JAGIELLONIAN UNIVERSITY MEDICAL COLLEGE   (Poland)

Author keywords

Intracellular cytokines; Monocytes; Pattern recognition receptors

Indexed keywords

CYTOKINE; FUCOIDIN; INTERLEUKIN 10; INTERLEUKIN 12; LIGAND; LOW DENSITY LIPOPROTEIN; MANNAN; MANNOSE RECEPTOR; MESSENGER RNA; MONOCLONAL ANTIBODY; PHOSPHATIDYLSERINE; POLYGUANYLIC ACID; RECEPTOR; SCAVENGER RECEPTOR; TUMOR NECROSIS FACTOR ALPHA;

ARTICLE; CONTROLLED STUDY; CYTOKINE PRODUCTION; FLOW CYTOMETRY; HUMAN; HUMAN CELL; MACROPHAGE; MONOCYTE; PATTERN RECOGNITION; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION;

CELL DIFFERENTIATION; CELLS, CULTURED; CYTOKINES; HUMANS; INTERLEUKIN-10; INTERLEUKIN-12; INTRACELLULAR MEMBRANES; LIGANDS; LIPOPROTEINS, LDL; MACROPHAGES; MANNANS; MONOCYTES; POLY G; POLYSACCHARIDES; RECEPTORS, IMMUNOLOGIC; RECEPTORS, SCAVENGER; RNA, MESSENGER; SCAVENGER RECEPTORS, CLASS A; SCAVENGER RECEPTORS, CLASS B; TUMOR NECROSIS FACTOR-ALPHA;

EID: 1642263389     PISSN: 10233830     EISSN: None     Source Type: Journal    
DOI: 10.1007/s00011-003-1233-1     Document Type: Article

References (26)

1. Medzhitov R, Janeway CA. Innate immune recognition and control of adaptive immune responses. Seminars in Immunology 1998; 10: 351-3.
2. Leteux C, Chai W, Loveless RW, Yuen CT, Uhlin-Hansen L, Combarnous Y et al. The cysteine-rich domain of the macrophage mannose receptor is a multispecific lectin thatrecoqnizes chondroitin sulfates A and B and sulfated oligosaccharides of blood group Lewis(a) and Lewis(x) types in addition to the sulfated N-glycans of lutropin. J exp Med 2000; 191: 1117-26.
3. Hiltbold EM, Vlad AM, Ciborowski P, Watkins SC, Finn OJ. The mechanism of unresponsiveness to circulating tumor antigen MUC1 is a block in intracellular sorting and processing by dendritic cells. J Immunol 2000; 165: 3730-41.
4. Savill J, Fadok V, Henson P, Haslett C. Phagocyte recognition of cells undergoing apoptosis. Immunol Today 1993; 14: 131-6.
5. Westenfelder U, Schraven B, Mannel DN. Characterization of monocyte-activating tumour cell membrane structures. Scand J Immunol 1993; 38; 388-94.
6. Utsugi T, Schroit AJ, Connor J, Bucana CD, Fidler IJ. Elevated expression of phosphatidylserine in the outer membrane of human tumor cells and recognition by human blood monocytes. Cancer Res 1991; 51; 3062-6.
7. Vitols S, Peterson C, Larsson O, Holm P, Aberg B. Elevated uptake of low density proteins by human lung cancer tissue in vivo. Cancer Res 1992; 52: 6244-7.
8. Zembala M, Czupryna A, Wiçckiewicz J, Jasiński M, Pryjma J, Ruggiero I et al. Tumour cell-induced production of tumour necrosis factor by monocytes of gastric cancer patients receiving BCG immunotherapy. Cancer Immunol Immunother 1993; 36: 127-32.
9. Mytar B, Siedlar M, Wołoszyn M, Ruggiero I, Pryjma J, Zembala M. Induction of reactive oxygen intermediates in human monocytes by tumor cells and their role in spontaneous monocyte cytotoxicity. Br J Cancer 1999; 79: 737-43.
10. Zembala M, Siedlar M, Marcinkiewicz J, Pryjma J. Human monocytes are stimulated for nitric oxide release in vitro by some tumor cells but not by cytokines and lipopolysaccharide. Eur J Immunol 1994; 24: 435-9.
11. Baran J, Kowalczyk D, Ożóg M, Zembala M. Three-color flow cytometry detection of intracellular cytokines in peripheral blood mononuclear cells: comparative analysis of phorbol myristate acetate-ionomycin and phytohemagglutinin stimulation. Clin Diagn Lab Immunol, 2001; 8: 303-13.
12. Basu SK, Goldstein JL, Andreson RG, Brown MS. Degradation of cationized low density lipoprotein and regulation of cholesterol metabolism in homozygous familial hypercholesterolemia fibroblasts. Proc natl Acad Sci USA 1976; 73: 3178-82.
13. Zembala M, Siedlar M, Ruggiero I, Wiȩckiewicz J, Mytar B, Mattei M et al. The MHC class II and CD44 molecules are involved in the induction of TNF gene expression by human monocytes stimulated with tumor cells. Int J Cancer 1994; 56: 269-74.
14. Mytar B, Baran J, Gawlicka M, Ruggiero I, Zembala M. Immunophenotypic changes and induction of apoptosis of monocytes and tumor cells during their interactions in vitro. Anticancer Res 2002; 22: 2789-96.
15. Mytar B, Wołoszyn M, Szatanek R, Baj-Krzyworzeka M, Siedlar M, Ruggiero I et al. Tumor cell-induced deactivation of human monocytes. J Leukoc Biol 2003; 74: (in press).
16. Heinzelmann M, Polk HC Jr, Miller FN. Modulation of lipopolysaccharide- induced monocyte activation by heparin-binding protein and fucoidan. Infect Immun 1998; 66: 5842-7.
17. Hsu HY, Chiu SL, Wen MH, Chen KY, Hua KF. Ligands of scavenger receptor induce cytokine expression via differential modulation of protein kinase signalling pathways. J Biol Chem 1998; 276: 28719-30.
18. Feng Y, Schreiner GF, Chakravarty S, Liu DY, Joly AH. Inhibition of the mitogen activated protein kinase, p38 alpha, prevents proinflammatory cytokine induction by human adherent mononuclear leukocytes in response to lipid loading. Atherosclerosis 2001; 158: 331-8.
19. M. Janabi, S. Yamashita, K. Hirano, N. Sakai, H. Hiraoka, K. Matsumoto et al. Oxidized LDL-induced NF-kappa B activation and subsequent expression of proinflammatory genes are defective in monocyte-derived macrophages from CD36-deficient patients. Arterioscler Thromb Vasc Biol 2000; 20: 1953-60.
20. Geng Y, Kodama T, Hansson GK. Differential expression of scavenger receptor isoforms during monocyte-macrophage differentiation and foam cell formation. Arterioscler Thromb 1994; 14: 798-806.
21. Ran S, Downes A, Thorpe PE. Increased exposure of anionic phospholipids on the surface of tumor blood vessels. Cancer Res 2002; 62: 6132-40.
22. Voll RE, Herrmann M, Roth EA, Stach C, Kalden JR. Immunosuppressive effect of apoptotic cells. Nature 1997; 390: 350-61.
23. Bzowska M, Guzik K, Barczyk K, Ernst M, Flad H-D, Pryjma J. Increased IL-10 production during spontaneous apoptosis of monocytes. Eur J Immunol 2002; 32: 2011-21.
24. Heale J-P, Speert DP. Macrophages in bacterial infections. In: Burke B, Lewis CE, editors. The macrophage. Oxford: Oxford University Press, 2002: 210-52.
25. Matzinger P. The danger model: A renewed sense of self. Science 2002; 296: 301-5.
26. Jessup W, Baoutina A, Kritharides L. Macrophages in cardiovascular disease. In: Burke B, Lewis CE, editors. The macrophage. Oxford: Oxford University Press, 2002: 490-522.