Paradoxical effect of cytosine arabinoside on mouse leukemia cell line L1210 cells

Anticancer Research

Volumn 25, Issue 1 A, 2005, Pages 157-160

  Nakayama, Tohru ^a   Sakamoto, Shinobu ^b,e   Sassa, Shuji ^b   Suzuki, Satoe ^b   Kudo, Hideki ^c   Nagasawa, Hiroshi ^d  

^a Nursing Science   (Japan)

^b TOKYO MEDICAL AND DENTAL UNIVERSITY   (Japan)

^c KAGAWA NUTRITION UNIVERSITY   (Japan)

^d MEIJI UNIVERSITY   (Japan)

^e Tokyo Scientific Research Institute   (Japan)

Author keywords

1 D arabinofuranosylcytosine; L1210 cells; Thymidine kinase; Thymidylate synthase

Indexed keywords

CYTARABINE; DNA FRAGMENT; THYMIDINE KINASE; THYMIDYLATE SYNTHASE;

ANIMAL CELL; ARTICLE; CELL CYCLE G0 PHASE; CELL CYCLE G1 PHASE; CELL CYCLE S PHASE; CELL GROWTH; CELL PROLIFERATION; CONTROLLED STUDY; DNA SYNTHESIS; DOSE RESPONSE; DRUG EFFECT; DRUG MEGADOSE; ENZYME ACTIVITY; LEUKEMIA CELL; LOW DRUG DOSE; MITOSIS INHIBITION; MOUSE; NONHUMAN; PRIORITY JOURNAL;

ANIMALS; ANTIMETABOLITES, ANTINEOPLASTIC; APOPTOSIS; CELL CYCLE; CELL LINE, TUMOR; CELL PROLIFERATION; CYTARABINE; DOSE-RESPONSE RELATIONSHIP, DRUG; LEUKEMIA L1210; MICE; S PHASE; THYMIDINE KINASE; THYMIDYLATE SYNTHASE;

EID: 16344384193     PISSN: 02507005     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (16)

1. Reuter C, Landwehr UA, Schleyer E, Zuhlsdorf M, Ameling C, Rolf C, Wormann B, Buchner T and Hiddemann W: Modulation of intra cellular metabolism of cytosine arabinoside in acute myeloid leukemia by granulocyte-macrophage colony-stimulating factor. Leukemia 8(2): 217-225, 1994.
2. Taylor AT, Stanford MA and Jones OW: Properties of thymidine kinase partially purified from human fetal and adult tissue. J Biol Chem 247: 1930-1935, 1972.
3. Herzfeld A and Raper SM: Relative activities of thymidylate synthetase and thymidine kinase in rat tissues. Cancer Res 40: 744-750, 1980.
4. Weber G, Lui MS, Takeda E and Denton JE: Enzymology of human colon tumor. Life Sci 39: 793-799, 1980.
5. Sakamoto S, Kuwa K, Tsukada K, Sagara T, Kasahara N and Okamoto R: Relative activities of thymidylate synthetase and thymidine kinase in 12-dimethylhydrazine-induced colon carcinoma in rats. Carcinogenesis 8: 405-408, 1987.
6. Okayasu I, Ohkusa T, Kajiura K, Kanno J and Sakamoto S: Promotion of colorectal neoplasia in experimental murine ulcerative colitis. Gut 39: 87-92, 1996.
7. Dunlap RB, Harding NGL and Huennekens FM: Thymidylate synthetase from amethopterin-resistant Lactobacillus casei. Biochemistry 10: 88-97, 1971.
8. Stubblefield E and Murphree S: Metabolic events in the regulation of cell reproduction. In: Handbook of Experimental Pharmacology. XXXVIII/1. Aruineoplastic and Immunosuppressive Agents I. (Sartorelli AC and Johns DG, eds). Springer-Verlag, Berlin, Chapter 9, 1974, pp 194-204.
9. Navalgund LG, Rossana C, Muench AJ and Johnson LF: Cell cycle regulation of thymidylate synthetase gene expression in cultured mouse fibroblasts. J Biol Chem 255(15): 7386-7390, 1980.
10. Bello LJ: Regulation of thymidine kinase synthesis in human cells. Exp Cell Res 89(2): 163-174, 1974.
11. Vial JP, Belloc F, Dumain P, Besnard S, Lacombe F, Boisseau MR, Reiffers J and Bernard P: Study of the apoptosis induced in vitro by antitumoral drugs on leukemic cells. Leukemic Res 21(2): 163-172, 1997.
12. Aglietta M and Colly L: Relevance of recruitment-synchronization in the scheduling of 1-β-D-arabinofuranosyl-cytosine in a slow-growing acute myeloid leukemia of the rat. Cancer Res 39: 2727-2732, 1979.
13. Gandhi V and Plunkett W: Modulation of arabinosylnucleoside metabolism by arabinosylnucleoside in human leukemia cells. Cancer Res 48: 329-334, 1988.
14. Spasokoutskaja T, Sasvari-Szekely M, Hullan L, Albertioni F, Eriksson S and Staub M: Activation of deoxycytidine kinase by various nucleoside analogues. Adv Exp Med Biol 431: 641-645, 1998.
15. Weinstein H, Griffin TW, Feeney J, Cohen HJ, Propper RD and Sallan SE: Pharmacokinetics of continuous intravenous and subcutaneous infusions of cytosine arabinoside. Blood 59(6): 1351-1353, 1982.
16. Spriggs D, Griffin J, Wisch J and Kufe D: Clinical pharmacology of low-dose cytosine arabinoside. Blood 65(5): 1085-1088, 1985.