The effect of bacterial toxins on levels of intracellular adenosine nucleotides and human ciliary beat frequency

Pulmonary Pharmacology

Volumn 9, Issue 4, 1996, Pages 223-230

  Kanthakumar, K ^a   Taylor, G W ^b   Cundell, D R ^a   Dowling, R B ^a   Johnson, M ^c   Cole, P J ^a   Wilson, R ^a  

^a NATIONAL HEART AND LUNG INSTITUTE   (United Kingdom)

^b HAMMERSMITH HOSPITAL   (United Kingdom)

^c GLAXOSMITHKLINE   (United Kingdom)

Author keywords

ATP; Bacterial toxins; cAMP; Cilia; Ciliary beat frequency; Pseudomonas aeruginosa

Indexed keywords

1 HYDROXYPHENAZINE; ADENOSINE; ADENOSINE TRIPHOSPHATE; BACTERIAL TOXIN; BUCLADESINE; CYCLIC AMP; LACTATE DEHYDROGENASE; NUCLEOTIDE; PYOCYANINE; RHAMNOLIPID; SALMETEROL; UNCLASSIFIED DRUG;

ARTICLE; BACTERIAL VIRULENCE; BACTERIUM CULTURE; CELL LEVEL; CILIARY MOTILITY; CILIATED EPITHELIUM; CONCENTRATION RESPONSE; CONTROLLED STUDY; ENZYME RELEASE; GEL FILTRATION; HAEMOPHILUS INFLUENZAE; HUMAN; HUMAN TISSUE; NOSE MUCOSA; PRIORITY JOURNAL; PSEUDOMONAS AERUGINOSA;

EID: 16344383494     PISSN: 09520600     EISSN: None     Source Type: Journal    
DOI: 10.1006/pulp.1996.0028     Document Type: Article

References (30)

1. 1. Wilson R. Secondary ciliary dysfunction. Clin Sci 1988; 75: 113-120.
2. 2. Wilson R, Roberts D, Cole P J. Effect of bacterial products on human ciliary function in vitro. Thorax 1985; 40: 125-131.
3. 3. Steinfort C, Wilson R, Mitchell T, Feldman C, Rutman A, Todd H, Sykes D, Walker J, Saunders C, Andrew P, Boulnois G, Cole P J. The effect of Streptococcus pneumoniae on human respiratory epithelium in vitro. Infect Immun 1989; 57: 2006-2013.
4. 4. Wilson R, Pitt T, Taylor G, Watson D, MacDermot J, Sykes D, Roberts D, Cole P J. Pyocyanin and 1-hydroxyphenazine produced by Pseudomonas aeruginosa inhibit human ciliary beating in vitro. J Clin Invest 1987; 79: 221-229.
5. 5. Read R C, Roberts P, Munro N, Rutman A, Hastie A, Shryock T, Hall R, McDonald-Gibson W, Lund V, Taylor G, Cole P J, Wilson R. Effect of Pseudomonas aeruginosa rhamnolipids on mucociliary transport and ciliary beating. J Applied Physiol 1992; 72: 2271-2277.
6. 6. Wilson R, Sykes D A, Watson D, Rutman A, Taylor G W, Cole P J. Measurement of Pseudomonas aeruginosa phenazine pigments in sputum and assessment of their contribution to sputum sol toxicity for respiratory epithelium. Infect Immun 1988; 56: 2515-2517.
7. 7. Kownatzki R, Tummler B, Doring G. Rhamnolipid of Pseudomonas aeruginosa in sputum of cystic fibrosis patients. Lancet 1987; 2: 1026-1027.
8. 8. Munro N, Barker A, Rutman A, Taylor G, Watson D, McDonald-Gibson W J, Towart R, Taylor W A, Wilson R, Cole P J. The effect of pyocyanin and 1-hydroxyphenazine on in vivo tracheal mucus velocity. J Applied Physiol 1989; 76: 316-323.
9. ++ and cAMP. Am J Physiol 1992; 263: L232-L242.
10. 10. Kanthakumar K, Taylor G, Tsang K W T, Cundell D R, Rutman A, Smith S, Jeffery P K, Cole P J, Wilson R. Mechanism of action of Pseudomonas aeruginosa pyocyanin on human ciliary beat in vitro. Infect Immun 1993; 61: 2848-2853.
11. 11. Kanthakumar K, Cundell D R, Johnson M, Wills P J, Taylor G W, Cole P J, Wilson R. Effect of salmeterol on human nasal epithelial cell ciliary beating: inhibition of the ciliotoxin, pyocyanin. Br J Pharmacol 1994; 112: 493-498.
12. 12. Fujita K, Akino T, Yoshioka H. Characteristics of a heat-stable extracellular haemolysin from Pseudomonas aeruginosa. Infect Immun 1988; 56: 1385-1387.
13. 13. Rendell N B, Taylor G W, Somerville M, Todd H, Wilson R, Cole P J. Characterisation of pseudomonas rhamnolipids. Biochim Biophys Acta 1990; 1045: 189-193.
14. 14. Wilson R, Moxon E R. Molecular basis of Haemophilus influenzae pathogenicity in the respiratory tract. In Griffiths E, Donachie W, Stephen J, ed. Bacterial infections of respiratory and gastrointestinal mucosa. Society for General Microbiology. Oxford: IRL Press 1988; 29-40.
15. 15. Read R C, Wilson R, Rutman A, Lund V, Todd H C, Brain A P R, Jeffery P K, Cole P J. Interaction of non typable Haemophilus influenzae with human respiratory mucosa in vitro. J Infect Dis 1991; 163: 549-558.
16. 16. Fick R B. Pathogenesis of the pseudomonas lung lesion in cystic fibrosis. Chest 1989; 96: 158-164.
17. 17. Rayner C F J, Cole P J, Wilson R. The management of chronic bronchial sepsis due to bronchiectasis. Clin Pulm Med 1994; 1: 348-355.
18. 18. Wilson R, Cole P. Respiratory tract infections. In Barnes P J, ed. Royal Brompton Review Series Volume 2: Respiratory Medicine - Recent Advances. Butterworths 1993; 95-122.
19. 19. Hoiby N. Microbiology of lung infections in cystic fibrosis patients. Acta Paediatr Scand 1982; 301: 33-54.
20. 20. Pier G B. Pulmonary disease associated with Pseudomonas aeruginosa in cystic fibrosis: current status of the host-bacterium interaction. J Infect Dis 1985; 151: 575-580.
21. 21. Verdugo P, Johnson N T, Tam P Y. β-Adrenergic stimulation of respiratory ciliary activity. J Appl Physiol 1980; 48: 868-871.
22. 22. Di Benedetto G, Marara-Schediac F S, Mehta S. Effect of cyclic AMP on ciliary activity of human respiratory epithelium. Eur Respir J 1991; 4: 789-795.
23. 23. Armstrong A V, Stewart-Tull D E S. The site of action of extracellular products of Pseudomonas aeruginosa in the electron-transport chain in mammalian cell respiration. J Med Microbiol 1971; 4: 263-269.
24. 24. Hassan H M, Fridovich I. Mechanism of the antibiotic action of pyocyanin. J Bacteriol 1980; 141: 156-163.
25. 25. Hassett D J, Charniga L, Bean K, Ohman D E, Cohen M S. Response of Pseudomonas aeruginosa to pyocyanin: mechanisms of resistance, antioxidant defenses, and demonstration of a manganese - cofactored superoxide dismutase. Infect Immun 1992; 60: 328-336.
26. 26. Devalia J H, Sapsford R J, Rusznak C, Toumbis M J, Davies R J. The effects of salmeterol and salbutamol on ciliary beat frequency of cultured human bronchial epithelial cells in vitro. Pulm Pharmacol 1992; 5: 257-263.
27. 27. Murata M, Monden M, Umeshita K, Nakano H, Kanai T, Gotoh M, Mori T. Role of intracellular calcium in superoxide-induced hepatocyte injury. Hepatology 1994; 19: 1223-1228.
28. 2+ extrusion from human platelets. Biochimica et Biophysica Acta 1992; 1105: 19-28.
29. 2+ uptake in human platelets by cAMP. Biochimica et Biophysica Acta 1992; 1105: 29-39.
30. 30. James M H, Johnson M. Effects of salmeterol on respiratory tract infections. Eur Respir J 1996; 9 (suppl 23): 264.