Efficacy and safety of 0.1 % retinaldehyde/6% glycolic acid (diacnéal®) for mild to moderate acne vulgaris : A multicentre, double-blind, randomized, vehicle-controlled trial

Dermatology

Volumn 210, Issue SUPPL. 1, 2005, Pages 14-21

  Poli, F ^a   Ribet, V ^a   Lauze, C ^a   Adhoute, H ^a   Morinet, P ^a  

^a Pierre Fabre Research Institute ^*  (France)

Author keywords

Acne vulgaris; Glycolic acid; Retinaldehyde

Indexed keywords

ANTI ACNE AGENT; ANTIBIOTIC AGENT; DIACNEAL; RETINALDEHYDE PLUS GLYCOLIC ACID; UNCLASSIFIED DRUG;

ACNE VULGARIS; ADOLESCENT; ADULT; BURNING SENSATION; CHILD; CLINICAL TRIAL; CONFERENCE PAPER; CONTROLLED CLINICAL TRIAL; CONTROLLED STUDY; DOUBLE BLIND PROCEDURE; DRUG EFFICACY; DRUG SAFETY; DRY SKIN; ERYTHEMA; FEMALE; HUMAN; MAJOR CLINICAL STUDY; MALE; MULTICENTER STUDY; PHARYNGITIS; PHASE 3 CLINICAL TRIAL; PRIORITY JOURNAL; PRURITUS; RANDOMIZED CONTROLLED TRIAL; SIDE EFFECT; SKIN INFLAMMATION; SKIN IRRITATION; SKIN TINGLING;

ACNE VULGARIS; ADOLESCENT; ADULT; BIOPSY; CHILD; DERMATOLOGIC AGENTS; DOUBLE-BLIND METHOD; DRUG COMBINATIONS; FEMALE; FOLLOW-UP STUDIES; GLYCOLATES; HUMANS; KERATOLYTIC AGENTS; MALE; PATIENT SATISFACTION; REMISSION INDUCTION; RETINALDEHYDE; TREATMENT OUTCOME; VEHICLES; WOUND HEALING;

EID: 16344380241     PISSN: 10188665     EISSN: None     Source Type: Journal    
DOI: 10.1159/000081498     Document Type: Conference Paper

References (10)

1. Dreno B, Poli F: Epidemiology of acne. Dermatology 2003;206:7-10.
2. Cunliffe WJ, Holland DB, Clark SM, Stables GI: Comedogenesis: Some aetiological, clinical and therapeutic strategies. Dermatology 2003;206:11-16.
3. Holland KT, Ingham E, Cunliffe WJ: The microbiology of acne. J Appl Bacteriol 1981;51:195-215.
4. Fort-Lacoste L, Verscheure Y, Tisne-Versailles J, Navarro R: Comedolytic effect of topical retinaldehyde in the rhino mouse model. Dermatology 1999;199(suppl):33-35.
5. Pechère M, Pechère JC, Siegenthaler G, Germanier L, Saurat J-H: Antibacterial activity of retinaldehyde against Propionibacterium acnes. Dermatology 1999;199(suppl):29-31.
6. Morel P, Vienne MP, Beylot C, Bonerandi JJ, Dreno B, Lehucher-Ceyrac D, Slimani S, Dupuy P: Clinical efficacy and safety of a topical combination of retinaldehyde 0.1 % with erythromycin 4% in acne vulgaris. Clin Exp Dermatol 1999;24:354-357.
7. Van Scott EJ, Yu RJ: Alpha hydroxy acids: Procedures for use in clinical practices. Cutis 1989;43:222-228.
8. Van Scott EJ, Yu RJ: Hyperkeratinization, corneocyte cohesion, and alpha hydroxy acids. J Am Acad Dermatol 1984;11:867-879.
9. Rizova E, Pagnoni A, Stoudemayer T, et al: Polarized light photography and videomicroscopy greatly enhance the capability of estimating the therapeutic response to a topical retinoid (adapalene) in acne vulgaris. Cutis 2001;68(suppl 4S):25-33.
10. Baur DA, Butler RCD: Current concepts in the pathogenesis and treatment of acne. J Oral Maxillofac Surg 1998;56:651-655.