The effects of Ananas comosus L. leaves on diabetic-dyslipidemic rats induced by alloxan and a high-fat/high-cholesterol diet

American Journal of Chinese Medicine

Volumn 33, Issue 1, 2005, Pages 95-105

  Xie, Weidong ^a   Xing, Dongming ^b   Sun, Hong ^a   Wang, Wei ^b   Ding, Yi ^b   Du, Lijun ^b  

^a INSTITUTE OF MEDICINAL PLANT DEVELOPMENT   (China)

^b TSINGHUA UNIVERSITY   (China)

Author keywords

Ananas comosus; Cholesterol; Diabetes; Dyslipidemia; Oxidation; Phenols; Triglycerides

Indexed keywords

ANANAS COMOSUS EXTRACT; FENOFIBRATE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; METFORMIN; OLIVE OIL; PHENOL DERIVATIVE; PLANT EXTRACT; TRIACYLGLYCEROL; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; BODY WEIGHT; CHOLESTEROL DIET; CONTROLLED STUDY; DIABETES MELLITUS; DYSLIPIDEMIA; HYPOGLYCEMIA; LIPID DIET; LIPID PEROXIDATION; MALE; NONHUMAN; ORAL GLUCOSE TOLERANCE TEST; PINEAPPLE; PLANT LEAF; RAT;

ANANAS; ANIMALS; CHOLESTEROL, DIETARY; DIABETES MELLITUS, EXPERIMENTAL; DIETARY FATS; DRUGS, CHINESE HERBAL; GLUCOSE TOLERANCE TEST; HYPERLIPIDEMIAS; LIPID PEROXIDATION; MALE; MALONDIALDEHYDE; PLANT LEAVES; RATS; RATS, WISTAR;

EID: 16344361940     PISSN: 0192415X     EISSN: None     Source Type: Journal    
DOI: 10.1142/S0192415X05002692     Document Type: Article

References (28)

1. Anila, L. and N.R. Vijayalakshmi. Flavonoids from Emblica officinalis and Mangifera indica - effectiveness for dyslipidemia. J. Ethnopharmacol. 79: 81-87, 2002.
2. Arisue, K., K. Uchida and N. Takeuchi. Changes in serum lipid and lipoproteins in alloxan-diabetic rats - studies for one year. Jikken Dobutsu 43(2): 217-226, 1994 (article in Japanese).
3. Bhatnagar, D. Lipid-lowering drugs in the management of hyperlipidemia. Pharmacol. Ther. 79(3): 205-230, 1998.
4. Chan, P.T., W.P. Fong, Y.L. Cheung, Y. Huang, W.K. Ho and Z.Y. Chen. Jasmine green tea epicatechins are hypolipidemic in hamsters ( Meoscricetus uratus) fed a high fat diet. J. Nutr. 129: 1094-1101, 1999.
5. Chaput, E., D. Maubrou-Sanchez, F.D. Bellamy and A.D. Edgar. Fenofibrate protects lipoproteins from lipid peroxidation: Synergistic interaction with alpha-tocopherol. Lipids 34(5): 497-502, 1999.
6. Damci, T., S. Tatliagac, Z. Osar and H. Ilkova. Fenofibrate treatment is associated with better glycemic control and lower serum leptin and insulin levels in type 2 diabetic patients with hypertriglyceridemia. Eur. J. Intern. Med. 14(6): 357-360, 2003.
7. Goth, M.D. Medical Pharmacology, 9th ed. Mosby, Saint Louis, MO, 1985, pp. 471-480.
8. Kim, H.K., T.S. Jeong, M.K. Lee, Y.B. Park and M.S. Choi. Lipid-lowering efficacy of hesperetin metabolites in high-cholesterol fed rats. Clin. Chim. Acta. 327(1-2): 129-137, 2003.
9. Krause, B.R. and H.M. Princen. Lack of predictability of classical animal models for hypolipidemic activity: A good time for mice? Atherosclerosis 140(1): 15-24, 1998.
10. La Cour, B., P. Molgaard and Z. Yi. Traditional Chinese medicine in treatment of hyperlipidaemia. J. Ethnopharmacol. 46(2): 125-129, 1995.
11. Mashiba, S., K. Uchida, S. Okuda and S. Tomita. Measurement of glycated albumin by the nitroblue tetrazolium colorimetric method. Clin. Chim. Acta. 212(1-2): 3-15, 1992.
12. May, L.D., J.H. Lefkowitch, M.T. Kram and D.E. Rubin. Mixed hepatocellular-cholestatic liver injury after pioglitazone therapy. Ann. Intern. Med. 136(6): 449-452, 2003.
13. Moharram, F.A., M.S. Marzouk, S.A. El-Toumy, A.A. Ahmed and E.A. Aboutabl. Polyphenols of Melaleuca quinquenervia leaves - pharmacological studies of grandinin. Phytother. Res. 17(7): 767-773, 2003.
14. Pal, S., N. Ho, C. Santos, P. Dubois, J. Mamo, K. Croft and E. Allister. Red wine polyphenolics increase LDL receptor expression and activity and suppress the secretion of ApoB100 from human HepG2 cells. J. Nutr. 133(3): 700-706, 2003.
15. Pompella, A., E. Maellaro, A.F. Casini, M. Ferrali, L. Ciccoli and M. Comporti. Measurement of lipid peroxidation in vivo: A comparison of different procedures. Lipids 22(3): 206 211, 1987.
16. Shirwaikar, A., K. Rajendran, C.D. Kumar and R. Bodla. Antidiabetic activity of aqueous leaf extract of Annona squamosa in streptozotocin-nicotinamide type 2 diabetic rats. J. Ethnopharmacol. 91: 171-175, 2004.
17. Song, L.L. Chinese Herbs. Administrant Department of National Chinese Traditional Medicine, Shanghai, China, 1999, Vol. 8, pp. 296-297 (in Chinese).
18. Sripanidkulchai, B., S. Na-nakorn, V. Wongpanich and P. Tanyakupta. A behavioral investigation on utilization of medicinal plants for dysuria at Pon District, Khon Kaen. Khon Kaen Univ. Res. J. 5(1): 4-10, 2000.
19. Sripanidkulchai, B., V. Wongpanich, P. Laupattarakasem, J. Suwansaksri and D. Jirakulsomchok. Diuretic effects of selected Thai indigenous medicinal plants in Rats. J. Ethnopharmacol. 75: 185-190, 2001.
20. Sun, L.H., D.M. Xing, M. Li, H. Sun, W. Jin, X.H. Meng and L.J. Du. Investigation into animal model with hyperglycemia and hyperlipidemia. Acta Acad. Med. Sci. 23(1): P.IV, 2001.
21. Sun, L.H., D.M. Xing, H. Sun, M. Li, W. Jin and L.J. Du. Effect of pueraria flavonoid on diabetes in mice complicated by hyperlipidemia. Tsinghua Sci. Technol. 7: 369-373, 2002.
22. Sundell, C.L., P.K. Somers, C.Q. Meng, L.K. Hoong, K.L. Suen, R.R. Hill, L.K. Landers, A. Chapman, D. Butteiger, M. Jones, D. Edwards, A. Daugherty, M.A. Wasserman, R.W. Alexander, R.M. Medford and U. Saxena. AGI-1067: A multifunctional phenolic antioxidant, lipid modulator, anti-inflammatory and antiatherosclerotic agent. J. Pharmacol. Exp. Ther. 305(3): 1116-1123, 2003.
23. Taskinen, M.R. Diabetic dyslipidemia. Atherosclerosis 3(Suppl.): 47-51, 2002.
24. Tikkanen, M.J., O.S. Wahalnk, V. Vihma and H. Adlercrentz. Effect of soybean phytoestrogen intake on low-density lipoprotein oxidation resistence. Proc. Natl. Acad. Sci. USA 95: 3106-3110, 1998.
25. Uchida, K., H. Takase, Y. Nomura, Y. Nakamura, H. Igimi, N. Takasu, H. Kurihara and N. Takeuchi. Development of atherosclerosis in alloxan diabetic rats. J. Atheroscler. Thromb. 1(2): 118-128, 1994.
26. Vaya, J., S. Mahmood, A. Goldblum, M. Aviram, N. Volkova, A. Shaalan, R. Musa and S. Tamir. Inhibition of LDL oxidation by flavonoids in relation to their structure and calculated enthalpy. Phytochemistry 62(1): 89-99, 2003.
27. Watts, G.F. and D.A. Playford. Dyslipoproteinaemia and hyperoxidative stress in the pathogenesis of endothelial dysfunction in non-insulin dependent diabetes mellitus: A hypothesis. Atherosclerosis 141(1): 17-30, 1998.
28. Xie, W.D., D.M. Xing, H. Su, J. Cheng, W. Jin, Y. Ding and L.J. Du. Slow gastrointestinal transit and possible links between them in alloxan-induced diabetic mice. Tsinghua Sci. Technol. 9(4): 397-405, 2004 (in press).