Increased levels of interleukin-4, 5 and 10 and decreased levels of interleukin-2 and interferon-gamma in lymphatic filariasis

Biomedical Research

Volumn 16, Issue 1, 2005, Pages 33-39

  Sharma, Alpana ^a   Rajappa, Medha ^b   Mehndiratta, P L ^b   Saxena, A ^b  

^a ALL INDIA INSTITUTE OF MEDICAL SCIENCES   (India)

^b MAULANA AZAD MEDICAL COLLEGE   (India)

Author keywords

Interferon gamma; Interleukin 2, 4, 5 and 10; Lymphatic filariasis; Th1 and Th2 responses; Wuchereria bancrofti

Indexed keywords

GAMMA INTERFERON; INTERLEUKIN 10; INTERLEUKIN 2; INTERLEUKIN 4; INTERLEUKIN 5;

ANTIGEN PURIFICATION; ARTICLE; CHRONIC DISEASE; CLINICAL ARTICLE; CLINICAL FEATURE; CONTROLLED STUDY; CYTOKINE PRODUCTION; DATA ANALYSIS; DIAGNOSTIC VALUE; DISEASE ASSOCIATION; ENDEMIC DISEASE; ENZYME LINKED IMMUNOSORBENT ASSAY; FILARIASIS; HELPER CELL; HUMAN; HUMAN TISSUE; IMMUNE RESPONSE; LYMPHATIC SYSTEM; MICROFILARIASIS; PERIPHERAL BLOOD MONONUCLEAR CELL; SENSITIZATION; STATISTICAL SIGNIFICANCE; TH1 CELL; TH2 CELL; WUCHERERIA BANCROFTI;

WUCHERERIA BANCROFTI;

EID: 16244412268     PISSN: 0970938X     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Article

References (36)

1. WHO Global Programme to eliminate Lymphatic Filariasis-Annual Report on lymphatic filariasis 2002; 28: 7-61.
2. Ottesen EA, Immmunopathology of lymphatic filariasis in man. Springer Semin. Immunopathol 1980; 2: 373-385.
3. + subset regulation in viral infection. Preferential activation of Th-2 cells during progression of retrovirus - induced immunodeficiency in man. J Immunol. 1992; 148: 182-185.
4. Pearce EJ, Caspar P, Grzych JM, Lewis FA, Sher A, Down regulation of Th-1 cytokine production accompanies induction of Th-2 responses by a parasitic helminth, Schistosoma mansoni. J Exp Med 1991; 173: 159-166.
5. Urban JFJ, Madden KB Svetic A, Cheever A, Trotta PP, Gause WC, Katona IM, Finkelman FD, The importance of Th-2 cytokines in protective immunity to nematodes. Immunol Rev 1992; 127: 205-209.
6. Mahanty S, King CL, Kumaraswami V, Regunathan J, Maya A, Jayaraman K, Abrams JS, Ottesen EA, Nutman TB, IL-4 and IL-5 secreting lymphocyte populations are preferentially stimulated by parasitic derived antigens in human tissue invasive nematode infections. J Immunol 1993; 151: 3704-3711.
7. Nielsen NO, Bloch P, Simonsen PE. Lymphatic filariasis-specific immune responses in relation to lymph oedema grade and infection status. I. Cellular responses. Trans R Soc Trop Med Hyg. 2002; 96: 446-452.
8. Mohanty S, Abrams JS, King CL, Limaye AP, Nutman TB, Parallel regulation of IL-4 and IL-5 in human helminth infections. J Immunol 1992; 148: 3567-3571.
9. King CL, Connelly M, Alpers MP, Bockarie M, Kazura JW. Transmission intensity determines lymphocyte responsiveness and cytokine bias in human lymphatic filariasis. J Immunol 2001; 166: 7427-7436.
10. Steel C, Ottenson EA. Evolution of immunologic responsiveness of persons living in an area of endemic bancroftarian filariasis a 17-year follow-up. J Infect Dis 2001; 184: 73-79.
11. Raman U, Eswaran D, Narayanan RB, Jayaraman K, Kaliraj P. Proinflammatory Cytokines secreted by monocytes of filarial patients. Microbiol Immunol. 1999; 43: 279-283, 1999.
12. Jenson JS, O'Connor K, Osborne J, Devaney E. Infection with microfilariae induces apoptosis of CD4 (+) T-lymphocytes: A mechanism of immune unresponsiveness in filariasis. Eur J Immunol 2002; 32: 858-867.
13. Romagnani S, Human Th-1 and Th-2 subsets doubt no more. Immunology Today. 1991; 12: 256-257.
14. Malhotra I, Ouma JH, Wamachi A, Kioko J, Mungai P, Njzovu M, Kazura JW, King CL Influence of maternal filariasis on childhood infection and immunity to Wuchereria bancrofti in Kenya. Infect Immun 2003; 71: 5231-5237.
15. Cox FEG, and Liew FY. Cell subsets and cytokines in parasitic infections. Immunology Today 1992; 13: 445.
16. Sharma A, Saxena A, and Talukdar B, Detection of W. bancrofti circulating antigen in patients with S. digitata glucan combination directed filarial antibodies. Biomed Res 1999; 10: 227-233.
17. Lowry OH, Rosebrough NJ, Farr AL, Randall RJ, Protein measurement with the Folin-Phenol reagent. J Biol Chem 1951; 193: 265-275.
18. Sharma A, Upadhyay SN. Cellular Immunoresponsiveness in rabbits with Setaria digitata filarial antigen and TDM adjuvant. Int J Immunopharmacol 1993; 15: 395-400.
19. Gajewski TF, Pinnas M, Wong T, Fitch FW. Murine Th-1 & Th-2 clones proliferate optimally in response to distinct antigen presenting cell populations. J Immunol 1991; 146: 1750-1758.
20. Sanchez FO, Rodriguez JI, Agndelo G Garcia LF, Immune responsiveness and lymphokine production in patients with tuberculosis and healthy controls. Infec Immun 1994; 62: 5673-5678.
21. Yamamura M, Wang XH, Ohmen JD, Uyemura K, Rea TH, Bloom BR, Modlin RL Cytokine patterns of immunologically mediated tissue damage. J Immunol 1992; 149: 1470-1475.
22. Chirgwin SR, Elzer PH, Coleman SU, Nowling JM, Hagius SD, Edmunds MD, Klei TR. Infection outcome and cytokine gene expression in Brugia pahangi infected gerbils (Meriones unguiculatus) sensitized with Brucella abortus. Infect Immun 2002; 70: 5938-5945.
23. Nutman TB, Kumaraswami V. Regulation of the immune response in lymphatic filariasis perspectives on acute and chronic infection with Wuchereria bancrofti in South India. Parasite Immunol 2001; 23: 389-399.
24. King, CL, Ottesen EA, Nutman TB. Cytokine regulation of antigen driven immunoglobulin production in filarial parasite infections in human. J Clin Invest 1990; 85: 1810-1815.
25. Limaye AP, Abrams JS, Silver JE, Ottesen EA, Nutman TB. Regulation of parasite-induced eosinophilia selectively increased IL-5 production in helminth-infected patients. J Exp Med 1990; 172: 399-404.
26. King CL, Mahanty S, Kumaraswami V, Abrams JS, Regunathan J, Jayaraman K, Ottesen EA, Nutman TB. Cytokine control of parasite-specific anergy in human lymphatic filariasis preferential induction of a regulatory T helper type 2-lymphocyte subset J Clin Invest 1993; 92: 1667-1673.
27. Lawrence RA, Devaney E. Lymphatic filariasis parallels between the immunology of infection in humans and mice. Parasite Immunol 2001; 23: 353-261.
28. King CL, Nutman TB. Biological role of helper T-cell subsets in helminth infections. Chem Immunol 1992; 54: 136-165.
29. Yazdanbaksh M, Sartono E, Kruize YCM, Kurniawan A., et al. Elevated levels of T-cell activation-antigen CD27 and increased IL-4 production in human lymphatic filariasis. Eur J Immunol 1993; 23: 3312-3317.
30. Steel C, Nutman TBCTLA-4 in Filarial Infections Implications for a Role in Diminished T Cell reactivity. J Immunol 2003; 170: 1930-1938.
31. Sartono E, Kruize YCM, Kurniawan A, Maizels RM, Yazdanbaksh M. In Th-2 biased lymphatic filarial patients, responses to purified protein derivative of Mycobacterium tuberculosis remain Th1 Eur J Immunol 1996; 26: 501-504.
32. Ottesen EA, Weller PF, Heck L. Specific cellular unresponsiveness in human filariasis. Immunol 1997; 33: 413-421.
33. Piessens WF, Partono F, Hoffman SL, Tatiwayanto S, Piessens PW, Palmeieri JR, Koiman J, Dennis DT, Carney WP. Antigen-specific suppressor T lymphocytes in human lymphatic filariasis. N Eng J Med 1982; 307: 144-148.
34. Ravichandran M, Mahanty S, Kumaraswami V, Nutman TB, Jayaraman K. Elevated IL-10 mRNA expression and down-regulation of Th1-type cytokines in microfilaraemic individuals with Wuchereria bancrofti infection. Parasite Immunol 1997; 19: 69-77.
35. Sharma A, Upadhyay SN. Antibody detection of filarial patients with S. digitata antigen using thin layer immunoassay and ELISA tests. Med Sci Res 1995; 23: 337-338.
36. Mossman, TR, Moore KW, The role of IL-10 in cross-regulation of Th-1 and Th-2 responses. Immunol. Today 1991; 12: A49-53.