Prograf produces a molecular environment favoring antifibrosis, an effect reversed by the addition of rapamune

Transplantation Proceedings

Volumn 37, Issue 1, 2005, Pages 148-149

  Brook, N R ^a   Waller, J R ^a   Bicknell, G R ^a   Nicholson, M L ^a  

^a UNIVERSITY OF LEICESTER   (United Kingdom)

Author keywords

[No Author keywords available]

Indexed keywords

CALCINEURIN INHIBITOR; COLLAGEN TYPE 3; CREATININE; GELATINASE A; GELATINASE B; MESSENGER RNA; PROTEIN; RAPAMYCIN; TACROLIMUS; TISSUE INHIBITOR OF METALLOPROTEINASE 1; TRANSFORMING GROWTH FACTOR BETA;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; CONFERENCE PAPER; CONTROLLED STUDY; CREATININE BLOOD LEVEL; DISEASE MARKER; DRUG ANTAGONISM; DRUG EFFECT; GENE EXPRESSION; GRAFT DYSFUNCTION; INTERMETHOD COMPARISON; KIDNEY FIBROSIS; KIDNEY FUNCTION; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; PROTEIN URINE LEVEL; RAT; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; SODIUM DEPLETION; TIME SERIES ANALYSIS; URINARY EXCRETION;

EID: 16244408964     PISSN: 00411345     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.transproceed.2004.12.148     Document Type: Conference Paper

References (4)

1. S. Jain, G.R. Bicknell, M.L. Nicholson Tacrolimus has less fibrogenic potential than cyclosporin A in a model of renal ischaemia-reperfusion injury Br J Surg 87 2000 1563
2. S. Jain, G.R. Bicknell, P.H. Whiting Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury Transplant Proc 33 2001 556
3. F.J. Dumont, M.J. Staruch, S.L. Koprak Distinct mechanisms of suppression of murine T cell activation by the related macrolides FK-506 and rapamycin J Immunol 144 1990 251
4. S. Jain, G.R. Bicknell, P.H. Whiting Rapamycin reduces expression of fibrosis-associated genes in an experimental model of renal ischaemia reperfusion injury Transplant Proc 33 2001 556