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Arachidonic acid epoxides: Isolation and structure of 2 hydroxy epoxide intermediates in the formation of 8,11,12-trihydroxy eicosatrienoic acid and 10,11,12-trihydroxy eicosatrienoic acid
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Pace-Asciak CR, Granström E and Samuelsson B: Arachidonic acid epoxides: Isolation and structure of 2 hydroxy epoxide intermediates in the formation of 8,11,12-trihydroxy eicosatrienoic acid and 10,11,12-trihydroxy eicosatrienoic acid. J Biol Chem 258: 6835-6840, 1983.
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Arachidonic acid epoxides. Demonstration through oxygen-18 labeled oxygen gas studies of an intramolecular transfer of the terminal hydroxyl group of 12S-hydroperoxy-eicosa-5,8,10,14-tetraenoic acid to form hydroxy epoxides
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Pace-Asciak CR: Arachidonic acid epoxides. Demonstration through oxygen-18 labeled oxygen gas studies of an intramolecular transfer of the terminal hydroxyl group of 12S-hydroperoxy-eicosa-5,8,10,14-tetraenoic acid to form hydroxy epoxides. J Biol Chem 259: 8332-8337, 1984.
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Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils
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Dho S, Grinstein S, Corey EJ, Su WG and Pace-Asciak CR: Hepoxilin A3 induces changes in cytosolic calcium, intracellular pH and membrane potential in human neutrophils. Biochem J 266: 63-68, 1990.
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Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4
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Laneuville O, Reynaud D, Grinstein S, Nigam S and Pace-Asciak CR: Hepoxilin A3 inhibits the rise in free intracellular calcium evoked by formyl-methionyl-leucyl-phenylalanine, platelet-activating factor and leukotriene B4. Biochem J 295: 393-397, 1993.
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Resolution by DEAE cellulose chromatography of the enzymatic steps in the transformation of arachidonic acid into 8,11,12-trihydroxy eicosatrienoic acid and 10,11,12-trihydroxy eicosatrienoic acid by rat lung
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Pace-Asciak CR, Mizuno K and Yamamoto S: Resolution by DEAE cellulose chromatography of the enzymatic steps in the transformation of arachidonic acid into 8,11,12-trihydroxy eicosatrienoic acid and 10,11,12-trihydroxy eicosatrienoic acid by rat lung. Prostaglandins 25 79-84, 1983.
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Epoxide hydratase assay in human platelets using hepoxilin A3 as a lipid substrate
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Purification of hepoxilin epoxide hydrolase from rat liver
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New products in the hepoxilin pathway: Isolation of 11-glutathionyl hepoxilin A3 through reaction of hepoxilin A3 with glutathione S-transferase
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Pace-Asciak CR, Laneuville O, Chang M, Reddy CC, Su W-G and Corey EJ: New products in the hepoxilin pathway: isolation of 11-glutathionyl hepoxilin A3 through reaction of hepoxilin A3 with glutathione S-transferase. Biochem Biophys Res Commun 163: 1230-1234, 1989.
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A glutathione conjugate of hepoxilin A3: Formation and action in the rat central nervous system
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Pace-Asciak CR, Laneuville O, Su W-G, Corey EJ, Gurevich N, Wu P and Carlen PL: A glutathione conjugate of hepoxilin A3: Formation and action in the rat central nervous system. Proc Natl Acad Sci (USA) 87: 3037-3041, 1990.
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Synthesis of racemic 11,12-cyclopropyl analogs of hepoxilins A3 and B3
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Jankov RP, Luo X, Demin P, Aslam R, Hannam V, Tanswell AK and Pace-Asciak CR: Hepoxilin analogs inhibit bleomycin-induced pulmonary fibrosis in the mouse. J Pharm Exp Ther 301: 435-440, 2002.
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The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPa isoform in transfected COS-7 cells
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Qiao N, Reynaud D, Demin P, Halushka PV and Pace-Asciak CR: The thromboxane receptor antagonist PBT-3, a hepoxilin stable analog, selectively antagonizes the TPa isoform in transfected COS-7 cells. J Pharm Exper Therap 307: 1142-1147, 2003.
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Pace-Asciak CR, Reynaud D, Demin P, Aslam R and Sun A: A new family of thromboxane receptor antagonists with secondary thromboxane synthase inhibition. J Pharm Exper Ther 301: 618-624, 2002.
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The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP
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Reynaud D, Hinek A and Pace-Asciak CR: The hepoxilin analog PBT-3 inhibits heparin-activated platelet aggregation evoked by ADP. FEBS Lett 515: 58-60, 2002.
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The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100
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Reynaud D, Clark D, Qiao N, Rand ML and Pace-Asciak CR: The hepoxilin stable analogue, PBT-3, inhibits primary, platelet-related hemostasis in whole blood measured in vitro with the PFA-100. Thromb Res 112: 245-248, 2003.
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