Three-dimensional quantitative structure (3-D QSAR) activity relationship studies on imidazolyl and N-pyrrolyl heptenoates as 3-hydroxy-3-methylglutaryl- CoA reductase (HMGR) inhibitors by comparative molecular similarity indices analysis (CoMSIA)

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 4, 2005, Pages 1027-1032

  Thilagavathi, Ramasamy ^a   Kumar, Raj ^a   Aparna, Vema ^a   Sobhia, M Elizabeth ^a   Gopalakrishnan, Bulusu ^a   Chakraborti, Asit K ^a  

^a NATIONAL INSTITUTE OF PHARMACEUTICAL EDUCATION AND RESEARCH NIPER   (India)

Author keywords

3D QSAR; HMG CoA; Imidazolyl heptenoates; N Pyrolyl heptenoates

Indexed keywords

3 HYDROXY 3 METHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; CHOLESTEROL MONOOXYGENASE (SIDE CHAIN CLEAVING); ENZYME INHIBITOR; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE INHIBITOR; IMIDAZOLE DERIVATIVE; UNCLASSIFIED DRUG;

ARTICLE; CHEMICAL STRUCTURE; COMPARATIVE STUDY; CORRELATION ANALYSIS; ENZYME INHIBITION; QUANTITATIVE STRUCTURE ACTIVITY RELATION;

EID: 16244386522     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.042     Document Type: Article

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