Molecular basis of the low activity of antitumor anthracenediones, mitoxantrone and ametantrone, in oxygen radical generation catalyzed by NADH dehydrogenase. Enzymatic and molecular modelling studies

European Journal of Medicinal Chemistry

Volumn 40, Issue 4, 2005, Pages 321-328

  Tarasiuk, Jolanta ^a,b   Mazerski, Jan ^a   Tkaczyk Gobis, Katarzyna ^a   Borowski, Edward ^a  

^a GDANSK UNIVERSITY OF TECHNOLOGY   (Poland)

^b UNIVERSITY OF SZCZECIN   (Poland)

Author keywords

Anthracenedione antitumor agents; Molecular modelling; NADH dehydrogenase; Oxygen radical generation

Indexed keywords

1,4 DIACETAMIDOANTHRAQUINONE; 1,4 DIAMINOQUINIZARIN; 1,4 DIETHYLAMINOANTHRAQUINONE; 1,4 DIETHYLAMINOQUINIZARINE; 5,8 DIHYDROXY 1,4 BIS[[(3 DIMETHYLAMINO)PROPYL]AMINO] 9,10 ANTHRACENEDIONE; AMETANTRONE; ANTHRACENE DERIVATIVE; ANTHRAQUINONE DERIVATIVE; DAUNORUBICIN; MITOXANTRONE; OXYGEN RADICAL; QUINIZARIN; REACTIVE OXYGEN METABOLITE; REDUCED NICOTINAMIDE ADENINE DINUCLEOTIDE DEHYDROGENASE; UNCLASSIFIED DRUG;

ARTICLE; CATALYSIS; CONCENTRATION RESPONSE; DRUG ACTIVITY; DRUG MECHANISM; DRUG PROTEIN BINDING; DRUG STRUCTURE; ELECTRIC POTENTIAL; ELECTROCHEMICAL ANALYSIS; ENZYME ACTIVITY; ENZYME MECHANISM; MOLECULAR MODEL; OXIDATION; REDUCTION; STRUCTURE ACTIVITY RELATION;

EID: 16244384650     PISSN: 02235234     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.ejmech.2004.10.005     Document Type: Article

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