Synthesis and antibacterial activities of 5-hydroxy-4-amino-2(5H)-furanones

Bioorganic and Medicinal Chemistry Letters

Volumn 15, Issue 4, 2005, Pages 919-921

  Lattmann, Eric ^a   Dunn, Simon ^a   Niamsanit, Suwanna ^b   Sattayasai, Nison ^b  

^a ASTON UNIVERSITY   (United Kingdom)

^b Khon Kaen University   (Thailand)

Author keywords

2(5H) Furanones; Antibacterials; Bioactivity; Synthesis

Indexed keywords

ANTIINFECTIVE AGENT; CHLORAMPHENICOL; FURANONE DERIVATIVE; GENTAMICIN; SULFURIC ACID; TOLUENE;

ANTIBACTERIAL ACTIVITY; ARTICLE; CATALYSIS; CONTROLLED STUDY; DRUG SCREENING; DRUG SYNTHESIS; ESCHERICHIA COLI; NONHUMAN; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

ESCHERICHIA COLI; PSEUDOMONAS; PSEUDOMONAS AERUGINOSA; STAPHYLOCOCCUS AUREUS;

EID: 16244368469     PISSN: 0960894X     EISSN: None     Source Type: Journal    
DOI: 10.1016/j.bmcl.2004.12.051     Document Type: Article

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15. 3) 300 K: 165.20 (C2), 141.73 (C4), 126.00 (C3), 99.21 (C5), 24.54 (Me) ppm
16. Inoculum preparation The bacteria were streaked on a nutrient agar plate to obtain a freshly isolated colony subsequently incubated overnight at 37°C. Four to five isolated colonies were added into Mueller Hinton broth (MHB) solution, incubated for 4 h at 37°C. The turbidity was adjusted to the McFarland tube and the solution was diluted with MHB to 1:200. Antibacterial dilution tested: The test solution was diluted with dimethyl sulfoxide (DMSO) and MHB in the ratio of 1:4 to get a final concentration of 512 g/ml. MHB (50 μl) was added to each of twelve wells except the first well. Dilutions were made, mixed and the solutions were then incubated overnight at 37°C. The MIC, the lowest concentration, which showed a clear solution, was examined for each compound. In order to determine the MBC, a loopful of each clear well was streaked onto a nutrient containing agar plate, which was subsequently incubated overnight at 37°C. The MBC was then determined as the lowest concentration, which has shown no visible colony for each chemical
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